Results 171 to 180 of about 14,518 (211)

Integrated Experimental and Computational Discovery of Repurposed and Novel Inhibitors Targeting <i>Staphylococcus aureus</i> Biofilms.

J Pharm Bioallied Sci
Omar AM, Mohammad KA, Almalki M, Abuelnaga KO, Ibrahim SRM.   +4 more
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Autoinduced synthesis of colicin E2

Molecular and General Genetics MGG, 1983
Escherichia coli K-12 cells carrying the high copy number plasmid ColE2-P9 and a sfiA-lacZ gene fusion exhibit abnormally high levels of SOS-regulated phi sfiA-lacZ expression. Increased sfiA-lacZ expression is caused by the action of colicin E2, which is a DNase, rather than by the presence of multiple copies of a binding site for LexA protein, the ...
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Novel synthetic analogs of the Pseudomonas autoinducer

Bioorganic & Medicinal Chemistry Letters, 1999
Release of virulence factors in Pseudomonas aeruginosa is regulated by two N-acylhomoserine lactones, PAI-1 and PAI-2, that activate the respective transcription factors LasR and RhlR. With the goal of developing novel therapeutic agents, we synthesized constrained analogs of PAI-1 and evaluated them in P. aeruginosa.
T, Kline, J, Bowman, B H, Iglewski, T, de Kievit, Y, Kakai, L, Passador   +5 more
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Autoinducing peptide-based quorum signaling systems in Clostridioides difficile

Current Opinion in Microbiology, 2022
The autoinducing peptide-based Agr system in Clostridioides difficile is involved in virulence factor expression, motility, and sporulation. This review highlights several of the recent discoveries regarding C. difficile Agr. Typical Agr systems rely on the combined activities of four proteins involved in peptide expression, peptide processing, peptide
Ummey Khalecha Bintha Ahmed, Jimmy D Ballard   +1 more
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Bacterial Interference Caused by Autoinducing Peptide Variants

Science, 1997
The synthesis of virulence factors and other extracellular proteins by Staphylococcus aureus is globally controlled by the agr locus, which encodes a two-component signaling pathway whose activating ligand is an agr -encoded autoinducing peptide.
G, Ji, R, Beavis, R P, Novick
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Peptide autoinducers in bacteria

Microbiology, 2009
The review classifies and analyzes the literature data on bacterial peptide autoinducers (AIs), responsible for intra- and interspecies communication (quorum sensing) between bacterial populations. The most important families of peptide AI are discussed, including a large group of bacteriocins, subdivided into lantibiotics (class I), unmodified heat ...
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Structural identification of autoinducer of Photobacterium fischeri luciferase

Biochemistry, 1981
Synthesis of bacterial luciferase in some strains of luminous bacteria requires a threshold concentration of an autoinducer synthesized by the bacteria and excreted into the medium. Autoinducer excreted by Photobacterium fischeri strain MJ-1 was isolated from the cell-free medium by extraction with ethyl acetate, evaporation of solvent, workup with ...
A, Eberhard, A L, Burlingame, C, Eberhard, G L, Kenyon, K H, Nealson, N J, Oppenheimer   +5 more
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Custom Synthesis of Autoinducers and Their Analogues

2010
Bacterial quorum sensing (QS) system is a unique target for the development of a new class of drugs that potentially control pathogenicity and attenuate virulence. Thus, it has been of significant interest to discover small organic molecules that modulate QS circuits by competing with the signaling molecules, or so-called autoinducers (AIs), for ...
Jun, Igarashi, Hiroaki, Suga
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Methods for Analysis of Bacterial Autoinducer‐2 Production

Current Protocols in Microbiology, 2011
AbstractQuorum sensing is a cell‐cell signaling process that many bacteria use to regulate gene expression as a function of the density of the population. This phenomenon involves the production, release, and response to small chemical molecules termed autoinducers.
Michiko E, Taga, Karina B, Xavier
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The Effect of Anabiosis Autoinducers on the Bacterial Genome

Microbiology, 2002
The mutagenic activity of chemical analogues of microbial anabiosis autoinducers (the autoregulatory d1 factors of cell differentiation), which act to inhibit cell proliferation, to enhance cell tolerance, and to induce the transition of cells to anabiotic state, was studied using the Ames test.
Il'inskaya O., Kolpakov A., Zelenikhin P., Kruglova Z., Choidash B., Doroshenko E., Mulyukin A., El'-Registan G.   +7 more
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