Results 181 to 190 of about 9,092 (223)
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Analogs of the autoinducer of bioluminescence inVibrio fischer
Archives of Microbiology, 1986The enzymes for luminescence in Vibrio fischeri are induced only when a sufficient concentration of a metabolic product (autoinducer) specifically produced by this species accumulates. It has previously been shown that the autoinducer is 3-oxohexanoyl homoserine lactone and that it enters the cells by simple diffusion. To further study the mechanism of
A Eberhard
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The Effect of Anabiosis Autoinducers on the Bacterial Genome
Microbiology, 2002The mutagenic activity of chemical analogues of microbial anabiosis autoinducers (the autoregulatory d1 factors of cell differentiation), which act to inhibit cell proliferation, to enhance cell tolerance, and to induce the transition of cells to anabiotic state, was studied using the Ames test.
Il'inskaya O. +7 more
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Novel synthetic analogs of the Pseudomonas autoinducer
Bioorganic & Medicinal Chemistry Letters, 1999Release of virulence factors in Pseudomonas aeruginosa is regulated by two N-acylhomoserine lactones, PAI-1 and PAI-2, that activate the respective transcription factors LasR and RhlR. With the goal of developing novel therapeutic agents, we synthesized constrained analogs of PAI-1 and evaluated them in P. aeruginosa.
T, Kline +5 more
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Custom Synthesis of Autoinducers and Their Analogues
2010Bacterial quorum sensing (QS) system is a unique target for the development of a new class of drugs that potentially control pathogenicity and attenuate virulence. Thus, it has been of significant interest to discover small organic molecules that modulate QS circuits by competing with the signaling molecules, or so-called autoinducers (AIs), for ...
Jun, Igarashi, Hiroaki, Suga
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Autoinduced synthesis of colicin E2
Molecular and General Genetics MGG, 1983Escherichia coli K-12 cells carrying the high copy number plasmid ColE2-P9 and a sfiA-lacZ gene fusion exhibit abnormally high levels of SOS-regulated phi sfiA-lacZ expression. Increased sfiA-lacZ expression is caused by the action of colicin E2, which is a DNase, rather than by the presence of multiple copies of a binding site for LexA protein, the ...
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Development of an Autoinducible Plasmid for Recombinant Protein Production
Protein & Peptide Letters, 2021Background: The production of recombinant proteins in E. coli involves such factors as host strains, expression vectors, culture media, and induction methods. The typical procedure to produce heterologous proteins consists of the following: (1) insertion of the target gene into a suitable vector to construct an overexpression plasmid, (2 ...
Young Kee Chae, Hakbeom Kim
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Peptide autoinducers in bacteria
Microbiology, 2009The review classifies and analyzes the literature data on bacterial peptide autoinducers (AIs), responsible for intra- and interspecies communication (quorum sensing) between bacterial populations. The most important families of peptide AI are discussed, including a large group of bacteriocins, subdivided into lantibiotics (class I), unmodified heat ...
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Structural identification of autoinducer of Photobacterium fischeri luciferase
Biochemistry, 1981Synthesis of bacterial luciferase in some strains of luminous bacteria requires a threshold concentration of an autoinducer synthesized by the bacteria and excreted into the medium. Autoinducer excreted by Photobacterium fischeri strain MJ-1 was isolated from the cell-free medium by extraction with ethyl acetate, evaporation of solvent, workup with ...
A, Eberhard +5 more
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Involvement of ATP and autoinducer‐2 in aerobic granulation
Biotechnology and Bioengineering, 2009AbstractAerobic granulation represents an important bacterium‐to‐bacterium self‐immobilization process that has been exploited for the treatment of a wide spectrum of wastewaters, but the mechanism behind still remains unclear in a microbiological sense.
Yanghui, Xiong, Yu, Liu
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Methods for Analysis of Bacterial Autoinducer‐2 Production
Current Protocols in Microbiology, 2011AbstractQuorum sensing is a cell‐cell signaling process that many bacteria use to regulate gene expression as a function of the density of the population. This phenomenon involves the production, release, and response to small chemical molecules termed autoinducers.
Michiko E, Taga, Karina B, Xavier
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