Results 91 to 100 of about 27,529 (230)
Concomitant occurrence of FXTAS and clinically defined sporadic inclusion body myositis: report of two cases. [PDF]
, 2017 This report describes unique presentations of inclusion body myositis (IBM) in two unrelated patients, one male and one female, with genetically and histologically confirmed fragile X-associated tremor/ataxia syndrome (FXTAS).
Bolitho, Samuel J +11 more
core +2 more sources
Advanced Science, Volume 13, Issue 5, 27 January 2026.The VHL‐HIF2α (VHL is Von Hippel‐Lindau) axis in adipocytes differentially regulates hematopoiesis and bone formation through stem cell factor (SCF) and chemerin, respectively. This hypoxia‐responsive pathway in adipocytes establishes a systemic signaling network with HSCs and MSCs to maintain tissue homeostasis, revealing a targetable axis for ...
Qian Li +6 more
wiley +1 more source
Acrodermatitis continua of Hallopeau: clinical perspectives. [PDF]
, 2019 Acrodermatitis continua of Hallopeau (ACH) is a rare, sterile pustular eruption of one or more digits. The condition presents with tender pustules and underlying erythema on the tip of a digit, more frequently arising on a finger than a toe.
Beck, Kristen M +5 more
core
Expert Perspective: Diagnosis and Treatment of Castleman Disease
Arthritis &Rheumatology, Volume 78, Issue 1, Page 12-25, January 2026.Castleman disease (CD) is a major diagnostic challenge for rheumatologists. Unicentric CD (UCD) involves one enlarged lymph node region, whereas multicentric CD (MCD) involves multiple enlarged lymph node regions. Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune‐mediated conditions.
Luke Y. C. Chen +2 more
wiley +1 more source
TLRs Go Linear – On the Ubiquitin Edge [PDF]
, 2017 Toll-like receptors (TLRs) are crucial in protecting the host from pathogens. However, their exact role in disease remains incompletely understood.
Walczak, H, Zinngrebe, J
core
AIF-1 gene does not confer susceptibility to Behçet's disease: Analysis of extended haplotypes in Sardinian population [PDF]
, 2018 Background BehcEet's disease (BD) is a polygenic immune-mediated disorder characterized by a close association with the HLA-B∗51 allele. The HLA region has a strong linkage disequilibrium (LD) and carries several genetic variants (e.g. MIC-A, TNF-α genes)
Angioni, Mm +11 more
core +3 more sources
SOCS1 deficiency—crossroads of autoimmunity and autoinflammation—two case reports
Frontiers in PediatricsSuppressors of cytokine signaling (SOCS) proteins play a critical role in regulating immune signaling pathways. Deficiency of SOCS1 leads to various autoimmune pathologies. We present two unrelated patients with distinct clinical manifestations.
Kajetan Trojovsky +10 more
doaj +1 more source
Development of the autoinflammatory disease damage index (ADDI) [PDF]
, 2016 OBJECTIVES: Autoinflammatory diseases cause systemic inflammation that can result in damage to multiple organs. A validated instrument is essential to quantify damage in individual patients and to compare disease outcomes in clinical studies.
Al-Mayouf, SM +48 more
core +2 more sources
NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1 [PDF]
, 2013 The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3
Bernhardt, Katharina +2 more
core +4 more sources