Results 81 to 90 of about 27,174 (202)
The Journal of Gene Medicine, Volume 28, Issue 8, August 2026.Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease for which there is currently no known cure. This systematic review explores the efficacy of genetic therapies used to target ALS in preclinical studies using in vivo rodent models. Outcomes investigated include the total number of motor neurons, rodent survival, and muscle function
Hannah E. Wedgwood +2 more
wiley +1 more source
Interleukin-1, inflammasomes, autoinflammation and the skin
Swiss Medical Weekly, 2012 Interleukin 1, one of the first cytokines discovered in the 1980s, and a potent mediator of fever, pain and inflammation, is at present experiencing a revival in biology and medicine. Whereas the mechanism of activation and secretion of interleukin 1β, which critically regulates the function of this molecule, has remained mysterious for some 30 ...
Contassot Emmanuel +2 more
openaire +4 more sources
Janus kinase 1/2 inhibition for the treatment of autoinflammation associated with heterozygous TNFAIP3 mutation [PDF]
, 2019 We report a case of autoinflammation caused by a heterozygous variant in TNFAIP3 manifesting as progressive neuroinflammation. Mutant A20 protein failed to control interferon-dependent transcription. We demonstrate excellent therapeutic response to Janus
Mulhern, CM +7 more
core +1 more source
Micrornas in autoinflammation and autoimmunity [PDF]
Pediatric Rheumatology, 2014 Micro(mi)RNAs are small non-coding RNAs that play critical roles in physiological networks by regulating genetic programs. They are conserved from worms to mammals and function as negative regulators of protein-encoding gene expression. Research on the role of miRNAs in pathophysiological conditions is very active since 10 years and several works ...
openaire +1 more source
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency [PDF]
The linear ubiquitin assembly complex (LUBAC) consists of HOIP, HOIL-1 and SHARPIN and is essential for proper immune responses. Individuals with HOIP and HOIL-1 deficiencies present with severe immunodeficiency, autoinflammation and glycogen storage ...
Rao, Anand Prahalad +61 more
core +1 more source
Modern concept of autoimmunity in rheumatology
Научно-практическая ревматология, 2018 Two fundamental pathologic processes are central to the spectrum of chronic inflammation mechanisms: autoimmunity and autoinflammation. Autoimmunity and autoinflammation are mutually potent pathologic processes; their development is considered within ...
E. L. Nasonov
doaj
Cholesterol-embolization syndrome: current perspectives
Vascular Health and Risk Management, 2019 Abdullah OzkokDepartment of Internal Medicine and Nephrology, Memorial Şişli Hospital, Istanbul, TurkeyAbstract: Cholesterol-embolization syndrome (CES) is a multisystemic disease with various clinical manifestations.
Ozkok A
doaj
Deep Immunophenotyping of Circulating T and B Cells in Relapsing Adult-Onset Still’s Disease
Current Issues in Molecular BiologyAdult-onset Still’s disease (AOSD) is a complex systemic inflammatory disorder, categorized as an ‘IL-1 driven’ inflammasomapathy. Despite this, the interaction between T and B cells remains poorly understood.
Valentina Myachikova +6 more
doaj +1 more source
Autoinflammation behind the curtain [PDF]
British Journal of Dermatology, 2018 Navarini, A. A., French, L. E.
openaire +4 more sources