Results 71 to 80 of about 24,725 (157)
Janus kinase 1/2 inhibition for the treatment of autoinflammation associated with heterozygous TNFAIP3 mutation [PDF]
, 2019 We report a case of autoinflammation caused by a heterozygous variant in TNFAIP3 manifesting as progressive neuroinflammation. Mutant A20 protein failed to control interferon-dependent transcription. We demonstrate excellent therapeutic response to Janus
Mulhern, CM +7 more
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Micrornas in autoinflammation and autoimmunity [PDF]
Pediatric Rheumatology, 2014 Micro(mi)RNAs are small non-coding RNAs that play critical roles in physiological networks by regulating genetic programs. They are conserved from worms to mammals and function as negative regulators of protein-encoding gene expression. Research on the role of miRNAs in pathophysiological conditions is very active since 10 years and several works ...
openaire +1 more source
Evidence for a role of autoinflammation in early-phase psoriasis
, 2019 Psoriasis is a common, inflammatory immune-mediated skin disease mainly presenting with plaques whose pathogenesis is based on the central role of interleukin (IL)-23/IL-17 axis.
Tavecchio, Simona +15 more
core +1 more source
Cytokine and Chemokine Profile in Amicrobial Pustulosis of the Folds: Evidence for Autoinflammation [PDF]
, 2015 Autoinflammation has recently been suggested in the pathogenesis of neutrophilic dermatoses but systematic studies on their cytokine profile are lacking.
E. Berti +4 more
core +1 more source
Autoinflammation behind the curtain [PDF]
British Journal of Dermatology, 2018 Navarini, A. A., French, L. E.
openaire +4 more sources
, 2020 Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by recurrent bacterial infections and defined by reduced levels of IgG, IgA, and/or IgM, insufficient response to polysaccharide vaccination, and an abnormal B-cell ...
Carsten S. Larsen (8362020) +5 more
core +1 more source
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency [PDF]
The linear ubiquitin assembly complex (LUBAC) consists of HOIP, HOIL-1 and SHARPIN and is essential for proper immune responses. Individuals with HOIP and HOIL-1 deficiencies present with severe immunodeficiency, autoinflammation and glycogen storage ...
Rao, Anand Prahalad +61 more
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