Results 71 to 80 of about 27,529 (230)
Autoinflammatory diseases. Part 1: concept, classification, immunobiology, diagnosis
Zdorovʹe RebenkaSystemic autoinflammatory diseases (SAIDs) are a group of inherited monogenic diseases characterized by dysregulated innate immunity leading to excessive activation of inflammatory pathways.
O.V. Shvaratska +7 more
doaj +1 more source
Predicting recalcitrant hyperinflammatory disease course in children with Kawasaki disease and MIS-C
Pediatric Rheumatology Online JournalBackground Hyperinflammation ranges from monophasic to rapidly progressive, life-threatening courses. Early biomarkers to identify high-risk children are needed.
Özlem Satirer +9 more
doaj +1 more source
Frontiers in Immunology, 2018 Immune cell activation is a stringently regulated process, as exaggerated innate and adaptive immune responses can lead to autoinflammatory and autoimmune diseases. Perhaps the best-characterized molecular pathway promoting cell activation is the nuclear
Tridib Das +3 more
doaj +1 more source
Cutaneous vasculitis and recurrent infection caused by deficiency in complement factor I [PDF]
, 2018 Cutaneous leukocytoclastic vasculitis arises from immune complex deposition and dysregulated complement activation in small blood vessels. There are many causes, including dysregulated host response to infection, drug reactions, and various autoimmune ...
Despina Eleftheriou +9 more
core +2 more sources
ACR Open Rheumatology, Volume 8, Issue 3, March 2026.Objective Juvenile dermatomyositis (JDM) is a rare childhood inflammatory myopathy, whereas spondyloarthritis (SpA) is an inflammatory arthropathy characterized by enthesitis and peripheral or axial involvement. We describe a series of patients diagnosed with JDM in childhood who later fulfilled classification criteria for SpA, a sequential phenotype ...
Austen Grooms +3 more
wiley +1 more source
Zdorovʹe RebenkaSystemic autoinflammatory diseases (SAIDs) are considered dysregulation disorders of the innate immune system characterized by systemic sterile inflammation independent of infection and autoreactive antibodies or antigen-specific T cells ...
О.В. Шварацька +7 more
doaj +1 more source
AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3 [PDF]
, 2015 Inflammation that contributes to acute cerebrovascular disease is driven by the proinflammatory cytokine interleukin-1 and is known to exacerbate resulting injury.
Coutts, G. +4 more
core +1 more source
ACR Open Rheumatology, Volume 8, Issue 3, March 2026.Objective Systemic lupus erythematosus (SLE) is an autoimmune disease that affects numerous organs. Neutrophil extracellular traps (NETs) contribute to sterile inflammation and autoantibody generation in SLE. Isolevuglandins (isoLGs) are reactive oxygen species that are formed during NETosis and contribute to chromatin expansion.
Jaya Krishnan +7 more
wiley +1 more source
Autoinflammatory diseases: a possible cause of thrombosis? [PDF]
, 2015 Autoinflammatory diseases are a group of disorders due to acquired or hereditary disfunction of innate immune system and characterized by systemic or localized manifestations. The prototype is Familial Mediterranean Fever, a monogenic hereditary disorder,
Francesco Orlandini +2 more
core +2 more sources
British Journal of Haematology, Volume 208, Issue 3, Page 819-828, March 2026.Summary VEXAS syndrome (vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic) is an X‐linked, systemic, haemato‐inflammatory syndrome caused by somatic mutations in the UBA1 gene. No standardized treatment guidelines exist, but evidence is emerging that treatment with hypomethylating agents (HMAs) can induce improvement of the inflammatory symptoms,
Fieke W. Hoff +3 more
wiley +1 more source