Results 51 to 60 of about 24,492 (179)
Predicting recalcitrant hyperinflammatory disease course in children with Kawasaki disease and MIS-C
Pediatric Rheumatology Online JournalBackground Hyperinflammation ranges from monophasic to rapidly progressive, life-threatening courses. Early biomarkers to identify high-risk children are needed.
Özlem Satirer +9 more
doaj +1 more source
The Journal of Gene Medicine, Volume 28, Issue 8, August 2026.Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease for which there is currently no known cure. This systematic review explores the efficacy of genetic therapies used to target ALS in preclinical studies using in vivo rodent models. Outcomes investigated include the total number of motor neurons, rodent survival, and muscle function
Hannah E. Wedgwood +2 more
wiley +1 more source
Zdorovʹe RebenkaSystemic autoinflammatory diseases (SAIDs) are considered dysregulation disorders of the innate immune system characterized by systemic sterile inflammation independent of infection and autoreactive antibodies or antigen-specific T cells ...
О.В. Шварацька +7 more
doaj +1 more source
Sarcoidosis and Autoinflammation
Inflammation and Regeneration, 2011 Sporadic early-onset sarcoidosis (EOS) and familial Blau syndrome (BS) form a distinct set of autoinflammatory diseases, both of which onset in infancy and show a clinical triad of dermatitis, arthritis and uveitis histologically composed of noncaseating epithelioid cell granuloma.
openaire +2 more sources
Allergy, Volume 81, Issue 8, Page 2582-2632, August 2026.ABSTRACT This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...
Torsten Zuberbier +221 more
wiley +1 more source
Acute Myocarditis: From Pathophysiology to Risk‐Stratified Management—A Clinical Review
European Journal of Clinical Investigation, Volume 56, Issue 8, August 2026.Stepwise approach to patients with suspected acute myocarditis, integrating the 2024 American College of Cardiology (ACC) four‐stage classification (Stages A–D) and the 2025 European Society of Cardiology (ESC) inflammatory myopericardial syndrome (IMPS) framework. Step 1 (Initial Assessment): clinical presentation, first‐line investigations (ECG, high‐
Michele Golino +9 more
wiley +1 more source
Clinical presentation, diagnosis, and treatment of chronic granulomatous disease
Frontiers in PediatricsChronic granulomatous disease (CGD) is caused by an impaired respiratory burst reaction in phagocytes. CGD is an X-linked (XL) (caused by pathogenic variants in CYBB) or autosomal recessive inborn error of immunity (caused by pathogenic variants in CYBA,
Olga Staudacher +4 more
doaj +1 more source
Immune Dysregulation in Branched Chain Organic Acidemias
Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.ABSTRACT Organic acidemias (OAs) are a group of inherited disorders, most commonly caused by defects in mitochondrial enzymes involved in amino acid and fatty acid metabolism. While they characteristically present with metabolic and neurological crises, growing evidence reveals a significant burden of chronic immune dysregulation in some disorders and ...
Abdul L. Shakerdi +3 more
wiley +1 more source
Interleukin-1, inflammasomes, autoinflammation and the skin
Swiss Medical Weekly, 2012 Interleukin 1, one of the first cytokines discovered in the 1980s, and a potent mediator of fever, pain and inflammation, is at present experiencing a revival in biology and medicine. Whereas the mechanism of activation and secretion of interleukin 1β, which critically regulates the function of this molecule, has remained mysterious for some 30 ...
Contassot Emmanuel +2 more
openaire +4 more sources
JIMD Reports, Volume 67, Issue 4, July 2026.ABSTRACT Biallelic pathogenic variants in PNPT1 cause combined oxidative phosphorylation deficiency 13 (COXPD13) (MIM #614932), linking mitochondrial dysfunction to type I interferon (IFN) activation through cytosolic leakage of mitochondrial double‐stranded RNA (mt‐dsRNA).
Dan Ross Brooks +15 more
wiley +1 more source