Results 61 to 70 of about 24,725 (157)

Human neutrophils drive skin autoinflammation by releasing interleukin (IL)-26

Autoinflammation is a sterile inflammatory process resulting from increased neutrophil infiltration and overexpression of IL-1 cytokines. The factors that trigger these events are, however, poorly understood. By investigating pustular forms of psoriasis,
Yatim, Ahmad, Grizzetti, Lorenzo, Baldo, Alessia, Gilliet, Michel, Vandenberghe-Durr, Sophie, Kuonen, François, Di Domizio, Jeremy, Jenelten, Raphael, Fries, Anissa, Paul, Carle, Conrad, Curdin, Modlin, Robert L   +11 more
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Table_1_A rapid turnaround gene panel for severe autoinflammation: Genetic results within 48 hours.docx

, 2022
There is an important unmet clinical need for fast turnaround next generation sequencing (NGS) to aid genetic diagnosis of patients with acute and sometimes catastrophic inflammatory presentations.
Kimberly Gilmour (474755), Dara McCreary (13827151), Barbara Jensen (9369424), Despina Eleftheriou (714345), Ebun Omoyinmi (125984), Paul Brogan (3455957), Fiona Price-Kuehne (4281358), Ying Hong (405852), Alice Burleigh (13827154)   +8 more
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Distinct Pattern of Atypical Megakaryocytes in VEXAS Syndrome

International Journal of Laboratory Hematology, EarlyView.
Andrew Y. Sung, Jackson W. Douglas, Olga K. Weinberg, Sharon K. Germans, Weina Chen   +4 more
wiley   +1 more source

Hair follicle stem cell fate supports distinct clinical endotypes in hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 473-483, March 2026.
Hair follicles (HFs) were extracted from skin biopsies. From these, original sequencing data were obtained and integrated with two independent studies to build a HF single‐cell transcriptomic atlas. It enabled delineating the fate of HF stem cells.
Audrey Onfroy, Francette Jean‐Louis, Philippe Le Corvoisier, Fanny Coulpier, Kévin Muret, Eric Bonnet, Raphaele Arrouasse, Caroline Boucle, Salwa Abid, Emilie Sbidian, Christina Bergqvist, Pierre Wolkenstein, Véronique Godot, Jean‐François Deleuze, Yves Lévy, Piotr Topilko, Etienne Audureau, Sophie Hue   +17 more
wiley   +1 more source

Proteomic Analysis of Regulated Dendritic Cell Endosomes Reveals Dynamic Adaptation to Antigen Uptake and Cross‐Presentation

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Phagocytosis of yeast activates recruitment of proteases and trafficking factors from the secretory and endosomal pathways to the IRAP compartment and subsequently phagosomes, promoting cross‐presentation. In the absence of Sec22b, IRAP endosome and phagosome maturation to late endosomes is accelerated.
Alice Senni, Louise Grumbach, Sara Ceccacci, Mathieu Frechin, Nicolas Goudin, Ida Chiara Guerrera, Barbara Bertocci, Peter van Endert   +7 more
wiley   +1 more source

Type I interferon mediated autoinflammation due to DNase II deficiency [PDF]

, 2017
Microbial nucleic acid recognition serves as the major stimulus to an antiviral response, implying a requirement to limit the misrepresentation of self nucleic acids as non-self and the induction of autoinflammation. By systematic screening using a panel
Lasne, Dominique, Beitz, Benoit, Quartier, Pierre, Bondet, Vincent, Girard, Muriel, Stefano Volpi, Patrick Nitschke, Paolo Picco, Taddio, Andrea, Anna Monica Bianco, Diego Vozzi, Frederic Rieux-Laucat, Rice, Gillian, Zeef, Leo, Rodero, Mathieu P, Caorsi, Roberta, Uggenti, Carolina, Barchet, Winfried, Porcheray, Fabrice, Crow, Yanick J., Bianco, Anna Monica, Fabrice Porcheray, Lasne, Dominic, Stocco, Gabriele, Uettwiller, Florence, Valencic, Erica, Frémond, Marie-Louise, Tesser, Alessandra, Dominique Lasne, Alessandra Tesser, Flavio Faletra, Marine Depp, Vozzi, Diego, Michael Dussiot, Nathalie Boddaert, Vincent Bondet, Charbit, Marina, Winfried Barchet, Gunther Hartmann, Seabra, Luis, Beltrand, Jacques, Crow, Yanick, Zeef, Leo A. H., Tiffany Pascreau, Jacques Beltrand, Annie Harroche, Marie-Louise Frémond, Brigitte Bader-Meunier, Depp, Marine, Picco, Paolo P, Gillian I. Rice, Neven, Bénédicte, Muriel Girard, Erica Valencic, Yanick J. Crow, Depp, Marine, M, Mathieu P. Rodero, Bartok, Eva, Chantal Brouzes, Depp, Marine,, Eva Bartok, Fabre, Monique, Frémond, Marie-Louise, Girard, Murial, Picard, Capucine, Luis Seabra, Serena Pastore, Evelyn Hartmann, Tommasini, Alberto, Darragh Duffy, Gabriele Stocco, Florence Uettwiller, Bader-Meunier, Brigitte, Erika Della Mina, Carolina Uggenti, Hermine, Olivier, Duffy, Darragh, Marco Gattorno, Fremond, Marie-Louise, Leo A H. Zeef, Bénédicte Neven, Candon, Sophie, Boddaert, Nathalie, Capucine Picard, Marie-Alexandra Alyanakian, Harroche, Annie, Annalisa Marcuzzi, Cagnard, Nicolas, Guillem, Flavia, Zeef, Leo A H., Polak, Michel, Rieux-Laucat, Frédéric, Marcuzzi, Annalisa, Faletra, Flavio, Piscianz, Elisa, Monique Fabre, Olivier Hermine, Della Mina, Erika, Alyanakian, Marie-Alexandre, Nicolas Cagnard, Kitabayashi, Naoki, Marina Charbit, Alyanakian, Marie-Alexandra, Marion Rabant, Pascreau, Tiffany, Flavia Guillem, Rabant, Marion, Hartmann, Evelyn, Benoit Beitz, Pastore, Serena, Brouzes, Chantal, Volpi, Stefano, Alberto Tommasini, Sophie Candon, Gattorno, Marco, Rodero, Mathieu P., Dussiot, Michael, Michel Polak, Picco, Paolo, Hartmann, Gunther, Andrea Taddio, Elisa Piscianz, Rice, Gillian I., Pierre Quartier, Neven, Bénédicte, Nitschke, Patrick, Neven, Bénédicte, Rodéro, Mathieu, Roberta Caorsi, Naoki Kitabayashi   +129 more
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Clinical Spectrum of Cutaneous, Ocular, and Hair Manifestations in Patients With Inborn Errors of Immunity: Insights From a Single Center in Turkey

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Inborn errors of immunity (IEI), previously referred to as primary immunodeficiencies, are a heterogeneous group of genetic disorders affecting immune development and function. While once considered rare, IEIs are increasingly recognized, particularly in regions with high consanguinity rates.
Burcu Cil Yılmaz, Sibel Kaplan Sarikavak, Sezin Naiboglu, Gulsah Kalay, Erkan Cakmak, Ozge Turkyilmaz Ucar, Selami Ulas, Nermin Kapci, Pinar Gokmirza, Cigdem Aydogmus   +9 more
wiley   +1 more source

Multi‐Omics Analysis of Human Blood Cells Reveals Unique Features of Age‐Associated Type 2 CD8 Memory T Cells

Aging Cell, Volume 25, Issue 2, February 2026.
Aging drives the accumulation of CXCR3‐ central memory CD8 T cells that exhibit Th2‐like transcriptional and epigenetic programs. These cells display a pathogenic Th2‐skewed profile and are associated with age‐related diseases, including asthma, chronic liver disease, and type 2 diabetes.
Hiroyuki Matsui, Marlene Cervantes, Mir M. Khalid, Alan Tomusiak, Varun Dwaraka, Jorge Landgrave‐Gomez, Prasanna Vadhana Ashok Kumaar, Qingwen Chen, Jessica Lasky‐Su, Jake Stone, Ritesh Tiwari, Ryan Kwok, Shuntaro Ichikawa, Benjamin D. Ambrose, Rebeccah R. Riley, Genesis Vega Hormazabal, Ariel Adkisson‐Floro, Andreea Cristina Alexandru, Ryan Smith, Birgit Schilling, Herbert G. Kasler, Eric Verdin   +21 more
wiley   +1 more source

Immune Deficiency and Autoinflammation, the " Yin" and " Yang" of the Immune System

Inborn errors of immunity (IEI) are immune system disorders caused by genetic mutations, often presenting with varying degrees of infection, immune dysregulation, lymphoproliferation, and tumor susceptibility.
SONG Hongmei, ZHOU Yu
core   +1 more source

From autoinflammation to autoimmunity: old and recent findings

, 2018
Autoimmune diseases and autoinflammatory diseases have a number of similar etiopathogenetic and clinical characteristics, including genetic predisposition and recurrent systemic inflammatory flares.
Caso, Paolo, Piercarlo Sarzi-Puttini, Francesco Caso, Fabiola Atzeni, Luisa Costa, Paolo Caso, Raffaele Scarpa, Costa, Luisa, Giuseppe Barilaro, Atzeni, Fabiola, Caso, Francesco, Masala, Ignazio Francesco, Sarzi-Puttini, Piercarlo, Nucera, Valeria, Scarpa, Raffaele, Ignazio Francesco Masala, Rossella Talotta, Talotta, Rossella, Barilaro, Giuseppe, Valeria Nucera   +19 more
core   +2 more sources