Results 1 to 10 of about 732,329 (269)
Open Biology, 2022 The cytokine interleukin 1 (IL-1) is an evolutionary innovation of vertebrates. Fish and amphibian have one IL1 gene, while mammals have two copies of IL1, IL1A and IL1B, with distinct expression patterns and differences in their proteolytic activation ...
Eva Hasel de Carvalho +4 more
doaj +1 more source
Inflammasomes: Mechanisms of Action and Involvement in Human Diseases
Cells, 2023 Inflammasome complexes and their integral receptor proteins have essential roles in regulating the innate immune response and inflammation at the post-translational level.
Dimitri Bulté +3 more
doaj +1 more source
Adult Still's disease: New horizons
Научно-практическая ревматология, 2021 Still's disease in children (systemic juvenile idiopathic arthritis - JIA) and adult Still's disease (ASD) are considered as systemic autoinflammatory diseases of unknown etiology, which are based on similar immunopathogenetic mechanisms associated with ...
E. L. Nasonov, E. Feist
doaj +1 more source
Frontiers in Immunology, 2022 Interleukin-1 (IL-1) is a primary cytokine of innate immunity and inflammation. IL-1 belongs to a complex family including ligands with agonist activity, receptor antagonists, and an anti-inflammatory cytokine.
Domenico Supino +8 more
doaj +1 more source
Научно-практическая ревматология, 2023 Pericarditis, a clinical syndrome characterized by inflammation and thickening of the pericardium, is one of the most common forms of inflammatory diseases of the cardiovascular system.
E. L. Nasonov +3 more
doaj +1 more source
Frontiers in Immunology, 2020 Schnitzler syndrome (SchS) is a rare autoinflammatory disease, characterized by urticarial rash, recurrent fever, osteo-articular pain/arthritis with bone condensation, and monoclonal gammopathy.
Isabel Hodl +3 more
doaj +1 more source
Kawasaki Disease and Systemic Juvenile Idiopathic Arthritis – Two Ends of the Same Spectrum
Frontiers in Pediatrics, 2021 Kawasaki disease (KD) and systemic juvenile idiopathic arthritis (sJIA) are two distinct systemic inflammatory diseases of childhood. Each diagnosis is based on criteria, but numerous clinical features are overlapping. As no specific diagnostic tests are
Ellen Go +6 more
doaj +1 more source
Molecular and functional characterization of chicken interleukin 1 receptor 2 (chIL-1R2)
Poultry Science, 2023 : Interleukin-1 receptor type 2 (IL1R2) is a decoy receptor for exogenous IL-1. However, its functional role in chicken immunity is poorly understood. Herein, chicken IL-1R2 (chIL-1R2) was identified and functionally characterized in vivo and in vitro ...
Anh Duc Truong +7 more
doaj +1 more source
Frontiers in Immunology, 2020 Diabetes mellitus is linked with metabolic stress that induces cellular damage and can provoke renal inflammation and fibrotic responses that eventually lead to chronic kidney disease. Because the inflammasome, interleukin 1 (IL-1), IL-1α/IL-β, and IL-1R
Talal Salti +8 more
doaj +1 more source
The journey of canakinumab; on- and off-label indications [PDF]
Beyond Rheumatology, 2019 The role of interleukin-1 (IL-1) has been studied in many diseases, ranging from auto-inflammatory diseases to malignancies, and much has been discovered.
Daniela Marotto +3 more
doaj +1 more source