Results 41 to 50 of about 732,329 (269)

Current approaches to diagnosing and treating macrophage activation syndrome in children with rheumatic diseases

Современная ревматология, 2015
Macrophage activation syndrome (MAS) is a severe life-threatening complication presenting with hemophagocytosis, pancytopenia, coagulopathy, and liver and CNS dysfunctions. The disease belongs to a group of histiocytic disorders.
M. M. Kostik, M. F. Dubko, V. V. Masalova, L. S. Snegireva, I. A. Chikova, E. A. Isupova, O. V. Kalashnikova, V. G. Chasnyk   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Molecular Regulation of Bone Turnover in Juvenile Idiopathic Arthritis: Animal Models, Cellular Features and TNFα

Frontiers in Bioscience-Landmark
We review the abnormal bone turnover that is the basis of idiopathic inflammatory or rheumatoid arthritis and bone loss, with emphasis on Tumor Necrosis Factor-alpha (TNFα)-related mechanisms.
Harry C Blair, Jonathan Soboloff, Irina L Tourkova, Jamie L. McCall, Suravi Ray, Margalit E Rosenkranz, Cristina Sobacchi, Lisa J Robinson, John B Barnett   +8 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Efficacy of anti-IL-1 treatment in familial Mediterranean fever: a systematic review of the literature

Biologics: Targets & Therapy, 2016
Jeroen CH van der Hilst,1,2 Michel Moutschen,3 Peter E Messiaen,1,2 Bernard R Lauwerys,4,5 Steven Vanderschueren6 1Department of Infectious diseases and Immunity, Jessa Hospital, Hasselt, 2Biomedical Research Institute, University of Hasselt, Hasselt ...
van der Hilst JC, Moutschen M, Messiaen PE, Lauwerys BR, Vanderschueren S   +4 more
doaj  

A modified assay for measuring thymocyte co-stimulatory activity

Memorias do Instituto Oswaldo Cruz, 1993
The observation that murine thymocytes increase their proliferation to interleukin 1 (IL-1) in the presence of phytohemagglutinin (PHA) when pre-incubated with interleukin 2 (IL-2) allowed the introduction of a modified assay for the measurement of IL-1 ...
Sergio R. Dalmau, Claudia S. Freitas, Wilson Savino   +2 more
doaj   +1 more source

Interleukin 1 , interleukin 1  and interleukin 1 receptor gene polymorphisms in psoriatic arthritis [PDF]

Rheumatology, 2004
Objectives. To investigate polymorphisms of interleukin (IL) 1, IL-1 and IL-1 receptor R1 genes in patients with psoriatic arthritis (PsA), their relationship to the age of onset of psoriasis and the pattern of joint involvement. Methods. One hundred and forty well-characterized patients with PsA were studied.
openaire   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

In Silico Bahan Aktif Epigallocatechin Gallate dari Sargassum cristaefolium untuk Menghambat Pembentukan Interleukin 1B pada Sindroma Mata Kering

Spizaetus
Sindroma mata kering adalah kondisi multifaktorial yang mengganggu air mata dan permukaan mata, menyebabkan ketidaknyamanan, gangguan penglihatan, dan kerusakan permukaan mata. Sargassum cristaefolium, alga coklat yang ditemukan di Indonesia, mengandung
Muhammad Nabil Faiq, Irma A. Pasaribu, Tamam Jauhar, Verna Biutifasari   +3 more
doaj   +1 more source