Results 101 to 110 of about 178,684 (248)

Selective IL‐23 Inhibition in Conventional Treatment‐Refractory Pyoderma Gangrenosum: A Multicenter, Retrospective Study

International Journal of Dermatology, EarlyView.
The clinical effects of selective IL‐23 inhibition in refractory pyoderma gangrenosum, highlighting progressive ulcer healing, reduction in inflammation and pain, and steroid‐sparing effect, supporting the role of the IL‐23/Th17 axis as a therapeutic target.
Luca Bettolini, Carlo Alberto Maronese, Federica Derlino, Giovanni Genovese, Chiara Moltrasio, Luisa Sarno, Stefano Buffon, Bianca Cei, Giammarco Granieri, Valentina Dini, Marco Romanelli, Vincenzo Maione, Stefano Bighetti, Marina Venturini, Edoardo Cammarata, Paola Savoia, Antonio Di Guardo, Luigi Gargiulo, Ruggero Cascio Ingurgio, Antonio Costanzo, Lorenza Burzi, Claudia Leporati, Nunzia Di Cristo, Nicola Zerbinati, Alex G. Ortega‐Loayza, Angelo Valerio Marzano   +25 more
wiley   +1 more source

Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network. [PDF]

, 2016
BACKGROUND: Tumour necrosis factor (TNF) superfamily cytokines and their receptors regulate diverse immune system functions through a common set of signalling pathways. Genetic variants in and expression of individual TNF superfamily cytokines, receptors
Lee, James C, Lyons, Paul A, Peters, James E, Richard, Arianne C, Schäffer, Alejandro A, Siegel, Richard M, Smith, Kenneth GC, Vahedi, Golnaz   +7 more
core   +10 more sources

Chronic Noninfectious Osteomyelitis: A Review of Imaging Findings

Indian Journal of Radiology and Imaging
Chronic noninfectious osteomyelitis or chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis, is an autoinflammatory bone disorder primarily affecting the pediatric age group. Currently, it is diagnosed on the
Stuti Chandola, Narendra Bagri, Savvas Andronikou, A.V. Ramanan, Manisha Jana   +4 more
doaj   +1 more source

A signalome screening approach in the autoinflammatory disease TNF Receptor Associated Periodic Syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing [PDF]

, 2017
TNF Receptor Associated Periodic Syndrome (TRAPS) is an autoinflammatory disease caused by mutations in TNF Receptor 1 (TNFR1). Current therapies for TRAPS are limited and do not target the pro-inflammatory signalling pathways that are central to the ...
Agmon-Levin, Agyemang, Bain, Beachy, Beisswenger, Blau, Bulua, Cerezo, Cha, Challa, Cho, Choi, de Jesus, Dickie, Douros, Drewe, Elizabeth Drewe, Elizabeth M. McDermott, Fairclough, Federici, Fukumoto, Gomez-Hurtado, Grazziela Figueredo, Greco, Hara, Harrison, Homan, Huggins, Ian Todd, Jenna Reps, Jon Garibaldi, Kan, Lachmann, Lipinski, Lobito, Lucy C. Fairclough, Mannsperger, Marcuzzi, Martineau, McDermott, Miotto, Mohamed Hamed, Mowers, Negm, Norman, Ogino, Ola H. Negm, Park, Pathak, Patrick J. Tighe, Paul Radford, Peckham, Piram, Quintans, Rani, Rebelo, Rebelo, Reilly, Richard J. Powell, Sachse, Sardana, Sevecka, Sevecka, Sha, Shalit, Shameer, Sharon Crouch, Simon, Stahlmann, Steve St-Gallay, Susan Bainbridge, Tauber, ter Haar, Tian, Todd, Todd, Tsivkovskii, Vaitla, Voskuhl, Werber, Yoneshima, Yousaf, Zapater, Zhang, Zhang, Zhang   +85 more
core   +2 more sources

Childhood versus adulthood-onset autoinflammatory disorders: myths and truths intertwined

Reumatismo, 2013
Autoinflammatory disorders are characterized by spontaneous episodes of systemic inflammation deriving from inherited defects of the innate immune system.
L. Cantarini, A. Vitale, O.M. Lucherini, I. Muscari, F. Magnotti, G. Brizi, B. Frediani, G.D. Sebastiani, M. Galeazzi, D. Rigante   +9 more
doaj   +1 more source

Long‐term echocardiographic findings in patients with idiopathic recurrent pericarditis treated with anakinra

Internal Medicine Journal, EarlyView.
Abstract Aim Idiopathic recurrent pericarditis (IRP) is considered an autoinflammatory disease, and interleukin 1 inhibitors, such as anakinra, are used to treat resistant cases. Constrictive pericarditis, a feared complication, continues to be a critical concern. In the biologic era, evidence on long‐term transthoracic echocardiographic (TTE) findings
Zeynep Toker Dincer, Damla Raimoglou, Erkin Yilmaz, Ayten Dag, Melike Melikoglu, Serdal Ugurlu   +5 more
wiley   +1 more source

Genomic and proteomic insights into hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, EarlyView.
A dual pathogenic model of HS involving both epithelial dysfunction and systemic inflammation is supported. The HLA‐DRA association hints at autoimmune overlap, but the proteomic signature which is dominated by innate immune mediators favours an autoinflammatory classification, which may guide future therapeutic strategies and patient stratification ...
Maria Argyropoulou, Emmanouil Stylianakis, Isis Ricaño‐Ponce, Nick Keur, Theodora Kanni, Dimitra Stergianou, Mihai G. Netea, Vinod Kumar, Evangelos J. Giamarellos‐Bourboulis   +8 more
wiley   +1 more source

OX40/OX40L modulation: A target for regulating T cells in cutaneous inflammatory disorders

Journal of the European Academy of Dermatology and Venereology, EarlyView.
OX40 and OX40L are a co‐stimulatory immune checkpoint pair. Modulation of this pair impacts multiple immune phenotypes and is an attractive target for immunotherapy in dermatological disorders. Trials are underway with the majority in atopic dermatitis and currently in phase 3 trials.
Aditya K. Gupta, Julia Steriopoulos, Vasiliki Economopoulos, Paradi Mirmirani, Vincent Piguet   +4 more
wiley   +1 more source

Hypergammaglobulinemia in the pediatric population as a marker for underlying autoimmune disease: a retrospective cohort study [PDF]

, 2014
Background: The significance of hypergammaglobulinemia as a marker of immune activation is unknown, as a differential diagnosis for hypergammaglobulinemia in children has not been adequately established.
Lo, Mindy S, Son, Mary Beth F, Sundel, Robert P, Zurakowski, David   +3 more
core   +1 more source

Toward an Inclusive, Congruent, and Precise Definition of Autoinflammatory Diseases

Frontiers in Immunology, 2017
Autoinflammatory disease was introduced as a concept in 1999, demarcating an entirely new group of diseases in clinical, immunological, and conceptual terms.
Per Wekell, Per Wekell, Stefan Berg, Stefan Berg, Anna Karlsson, Anders Fasth, Anders Fasth   +6 more
doaj   +1 more source