Results 81 to 90 of about 171,535 (264)
Designation of Autoinflammatory Skin Manifestations With Specific Genetic Backgrounds
Frontiers in Immunology, 2020 “Autoinflammatory disease (AiD)” has first been introduced in 1999 when the responsible gene for the familial Hibernean fever or autosomal dominant-type familial Mediterranean fever-like periodic fever syndrome was reportedly identified as tumor necrosis
Nobuo Kanazawa
doaj +1 more source
Attempts to identify the molecular cause of autoinflammatory recurrent fever
Systemic autoinflammatory diseases caused by dysregulation of the innate immunity are a known cause of recurrent fevers. We present the molecular diagnosis results of 12 children with recurrent fever, analyzing the correlation between molecular findings ...
Diana Savkiv, Oksana Boyarchuk
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Ruxolitinib pharmacokinetics (PK) has been characterized in clinical trials but remains poorly documented in real‐world practice. This project aimed to investigate ruxolitinib PK in routine clinical practice, identify factors driving its variability, and explore exposure–response relationships to assess the potential role of therapeutic drug monitoring.
Jérémie Tachet +11 more
wiley +1 more source
Journal of Ultrasound in Medicine, EarlyView.Suppurative nevus comedonicus (SNC) is a variant of nevus comedonicus in which the characteristic features coexist with recurrent inflammatory lesions that clinically resemble those of hidradenitis suppurativa (HS). We present the ultrasound characteristics of this entity and emphasize the value of high‐resolution dermatologic ultrasound both as a ...
Marta Ivars +4 more
wiley +1 more source
The Role of Serum Zinc, Iron, Magnesium, and Selenium Levels in the Pathogenesis of PFAPA Syndrome
Archives of Basic and Clinical ResearchObjective: To investigate the potential role of zinc, iron, magnesium, and selenium in the pathogenesis of Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis (PFAPA) syndrome.
Fatma Atalay, Murat Yaşar
doaj +1 more source
Pediatric Rheumatology Online Journal, 2020 Background Deficiency of the natural antagonist of interleukin-1 was first described in 2009 and so far 20 patients has been reported. In Brazil just two cases have been reported both carrying the same homozygous 15 bp deletion.
Leonardo Oliveira Mendonça +9 more
doaj +1 more source
JEADV Clinical Practice, EarlyView.ABSTRACT Background Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis associated with systemic inflammatory diseases and malignancy. Although biologic therapies demonstrate efficacy in PG, the extent of their real‐world use remains incompletely characterized.
Rhiannon Grange +4 more
wiley +1 more source
New Mechanisms in Autoinflammatory Diseases
, 2017 New knowledge on the role of RhoA in the modulation of the pyrin inflammasome opened the way to a better understanding of two apparently unrelated autoinflammatory disorders: Familial Mediterranean Fever (FMF; OMIM#249100) and Mevalonate Kinase ...
Alberto Tommasini +3 more
core
Autoinflammatory Mechanisms in Crystal-Induced Arthritis [PDF]
, 2020 Crystal-induced arthritides have been classified as "type-1 autoinflammatory diseases" for their main features which resemble those of the monogenic autoinflammatory syndromes.
Scanu, Anna +13 more
core +1 more source
Juvenile Gangrenous Vasculitis of the Scrotum or Scrotum Lipschütz Ulcers
JEADV Clinical Practice, EarlyView.ABSTRACT Lipschütz genital ulcers are traditionally described in adolescent females and often linked to acute viral infections. Their male counterpart remains poorly characterised. We report a 59‐year‐old man with sudden onset of unilateral necrotic ulcers on the scrotum and inguinal region following a brief febrile episode and mild pharyngitis ...
Francesco Bellinato +2 more
wiley +1 more source