Results 41 to 50 of about 159,270 (192)

Long-Term Outcomes of Behçet’s Syndrome-Related Uveitis: A Monocentric Italian Experience

Mediators of Inflammation, 2020
Objectives. To examine demographic and clinical characteristics and long-term visual outcome in a cohort of Italian patients affected by Behçet’s uveitis (BU). Materials and Methods.
Jurgen Sota, Luca Cantarini, Antonio Vitale, Arianna Sgheri, Stefano Gentileschi, Valeria Caggiano, Viviana Gelardi, Bruno Frediani, Gian Marco Tosi, Claudia Fabiani   +9 more
doaj   +1 more source

Monogenic autoinflammatory diseases in children: single center experience with clinical, genetic, and imaging review

Insights into Imaging, 2020
Purpose 1. To review the contemporary literature and present a list of the imaging findings for patients with autoinflammatory diseases from our hospital. All these patients are found to have a genetic mutation that is responsible for their disease.
Alaa N. Alsharief, Ronald M. Laxer, Qiuyan Wang, Jennifer Stimec, Carina Man, Paul Babyn, Andrea S. Doria   +6 more
doaj   +1 more source

Somatic Mutations and the Risk of Undifferentiated Autoinflammatory Disease in MDS: An Under-Recognized but Prognostically Important Complication

Frontiers in Immunology, 2021
Objectives: We theorized that myelodysplastic syndrome (MDS) with somatic mutations and karyotype abnormalities are associated with autoinflammation, and that the presence of autoinflammatory disease affected prognosis in MDS.Methods: One hundred thirty ...
Abdulla Watad, Abdulla Watad, Mark Kacar, Mark Kacar, Nicola Luigi Bragazzi, Qiao Zhou, Qiao Zhou, Miriam Jassam, Jan Taylor, Eve Roman, Alexandra Smith, Richard A. Jones, Howard Amital, Catherine Cargo, Dennis McGonagle, Sinisa Savic, Sinisa Savic   +16 more
doaj   +1 more source

Claustrum Involvement in New Onset Refractory Status Epilepticus: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The claustrum sign is a distinctive neuroimaging finding characterized by bilateral T2/FLAIR hyperintensity of the claustrum, one of the most interconnected regions of the human brain. It was first described in new‐onset refractory status epilepticus (NORSE) and febrile infection–related epilepsy syndrome (FIRES).
Margherita Burani, Lorenzo Muccioli, Giada Giovannini, Niccolò Orlandi, Francesca Bisulli, Stefano Meletti   +5 more
wiley   +1 more source

Efficacy of combined JAK1/2 inhibition and cyclosporine in paediatric-onset Still’s disease with lung involvement: a case report

Pediatric Rheumatology Online Journal
Background Paediatric-onset Still’s disease is a severe autoinflammatory disorder marked by high fever, systemic inflammation, rash, organomegaly, and arthritis.
Serena Palmeri, Maddalena Lancieri, Jacopo Ferro, Pietro Salvati, Martino Cheli, Riccardo Papa, Silvia Rosina, Stefano Volpi, Valerio Gaetano Vellone, Angelo Ravelli, Marco Gattorno, Roberta Caorsi   +11 more
doaj   +1 more source

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

Arthritis Care &Research, EarlyView.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source

Molecular biology of autoinflammatory diseases

Inflammation and Regeneration, 2021
The long battle between humans and various physical, chemical, and biological insults that cause cell injury (e.g., products of tissue damage, metabolites, and/or infections) have led to the evolution of various adaptive responses.
Junya Masumoto, Wei Zhou, Shinnosuke Morikawa, Sho Hosokawa, Haruka Taguchi, Toshihiro Yamamoto, Mie Kurata, Naoe Kaneko   +7 more
doaj   +1 more source

Drug Retention Rates and Treatment Discontinuation among Anti-TNF-α Agents in Psoriatic Arthritis and Ankylosing Spondylitis in Clinical Practice

Mediators of Inflammation, 2014
Objective. The study aim was to determine treatment persistence rates and to identify causes of discontinuation in psoriatic arthritis (PsA) and ankylosing spondylitis (AS) patients in clinical practice. Methods.
Marta Fabbroni, Luca Cantarini, Francesco Caso, Luisa Costa, Veronica Anna Pagano, Bruno Frediani, Stefania Manganelli, Mauro Galeazzi   +7 more
doaj   +1 more source

Modulation of Autoimmune and Autoinflammatory Diseases by Gasdermins

Frontiers in Immunology, 2022
Autoimmune diseases and autoinflammatory diseases are two types of the immune system disorders. Pyroptosis, a highly inflammatory cell death, plays an important role in diseases of immune system.
Fang Liang, Weixiao Qin, Yilan Zeng, Dan Wang   +3 more
doaj   +1 more source

Development of a Disease Activity Index for the Assessment of VEXAS Syndrome (VEXAS‐DAI)

Arthritis Care &Research, Accepted Article.
Objective VEXAS syndrome is characterized by a complex spectrum of inflammatory and hematologic manifestations. Clinical research to identify effective therapies is urgently needed but is hindered by the lack of validated outcome measures. A VEXAS‐specific disease activity index (DAI) is an essential tool for reliably capturing changes in disease ...
Kevin Byram, Heřman Mann, Danielle Hammond, Onima Chowdhury, Sinisa Savic, Yohei Kirino, Carmelo Gurnari, Maël Heiblig, Thibault Comont, Arsène Mekinian, Mrinal M. Patnaik, Lachelle D. Weeks, Gary Ho, Adam Al‐Hakim, Scott Goldberg, Marcela A. Ferrada, Sophie Georgin‐Lavialle, Peter C. Grayson, Emma M. Groarke, Bhavisha Patel, Megan Sullivan, Sarah A. Buckley, Bryan G. Harder, Raman Garcha, David B. Beck, Matthew J. Koster   +25 more
wiley   +1 more source