Results 41 to 50 of about 168,848 (280)

Autoinflammatory diseases [PDF]

Clinical pharmacology and therapy, 2020
Autoinflammatory diseases are a group of disorders caused by a dysregulation of the innate immune system. Unlike autoimmune diseases, they are not associated with changes in humoral or cellular immunity. The authors review the current classification, clinical manifestations and treatment of various systemic autoinflammatory diseases, including ...
V.V. Rameev, L.V. Lysenko (Kozlovskaya), M.V. Bogdanova, S.V. Moiseev   +3 more
openaire   +1 more source

Toward an Inclusive, Congruent, and Precise Definition of Autoinflammatory Diseases

Frontiers in Immunology, 2017
Autoinflammatory disease was introduced as a concept in 1999, demarcating an entirely new group of diseases in clinical, immunological, and conceptual terms.
Per Wekell, Per Wekell, Stefan Berg, Stefan Berg, Anna Karlsson, Anders Fasth, Anders Fasth   +6 more
doaj   +1 more source

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome [PDF]

, 2009
Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-1 beta (IL-1 beta) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes triggered by microbial ligands, danger-associated molecular patterns
Mohamed Lamkanfi, James L. Mueller, Alberto C. Vitari, Shahram Misaghi, Anna Fedorova, Kurt Deshayes, Wyne P. Lee, Hal M. Hoffman, Vishva M. Dixit, Aguilar-Bryan, Ashcroft, Boyden, Cassel, Clement, Dostert, Duncan, Halle, Hamon, Hoffman, Hornung, Kanneganti, Kanneganti, Laliberte, Lamkanfi, Lamkanfi, Locovei, Ma, Mariathasan, Mariathasan, Martinon, Marty, Meyer, Miki, Miki, Pelegrin, Pelegrin, Perregaux, Riddle, Rosengren, Schott, Solle, Stoller, Sutterwala, Yvan-Charvet   +43 more
core   +2 more sources

Autoimmunity, Autoinflammation, and Infection in Uveitis [PDF]

, 2018
Funding/Support: No funding or grant support. Financial Disclosures: John V. Forrester has received an honorarium for lecturing from Janssen (London, UK). Lucia Kuffova has undertaken consultancy work for Abbvie (London, UK). Andrew D.
Dick, Andrew D., Forrester, John V., Kuffova, Lucia   +2 more
core   +4 more sources

Somatic Mutations and the Risk of Undifferentiated Autoinflammatory Disease in MDS: An Under-Recognized but Prognostically Important Complication

Frontiers in Immunology, 2021
Objectives: We theorized that myelodysplastic syndrome (MDS) with somatic mutations and karyotype abnormalities are associated with autoinflammation, and that the presence of autoinflammatory disease affected prognosis in MDS.Methods: One hundred thirty ...
Abdulla Watad, Abdulla Watad, Mark Kacar, Mark Kacar, Nicola Luigi Bragazzi, Qiao Zhou, Qiao Zhou, Miriam Jassam, Jan Taylor, Eve Roman, Alexandra Smith, Richard A. Jones, Howard Amital, Catherine Cargo, Dennis McGonagle, Sinisa Savic, Sinisa Savic   +16 more
doaj   +1 more source

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. [PDF]

, 2020
Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification ...
Ailal, Fatima, Al-Herz, Waleed, Bousfiha, Aziz, Casanova, Jean-Laurent, Chatila, Talal, Cunningham-Rundles, Charlotte, Etzioni, Amos, Franco, Jose Luis, Holland, Steven M, Jeddane, Leila, Klein, Christoph, Morio, Tomohiro, Ochs, Hans D, Oksenhendler, Eric, Picard, Capucine, Puck, Jennifer, Sullivan, Kathleen E, Tangye, Stuart G, Torgerson, Troy R   +18 more
core  

The burgeoning field of innate immune-mediated disease and autoinflammation. [PDF]

, 2016
Immune-mediated autoinflammatory diseases are occupying an increasingly prominent position among the pantheon of debilitating conditions that afflict mankind.
McDermott, MF, Peckham, D, Savic, S, Scambler, T   +3 more
core   +1 more source

Protein misfolding and dysregulated protein homeostasis in autoinflammatory diseases and beyond. [PDF]

, 2015
Cells have a number of mechanisms to maintain protein homeostasis, including proteasome-mediated degradation of ubiquitinated proteins and autophagy, a regulated process of ‘self-eating’ where the contents of entire organelles can be recycled for other ...
A Halle, A Kaser, A Kitamura, A Simon, AA Lobito, AB Singleton, AC Bulua, AK Agarwal, AM Cuervo, Amma F. Agyemang, AR Simard, AR Winslow, AV Matveyenko, B Levine, B Nedjai, B Neerinckx, B Shi, B Wang, C Dode, C Hetz, C Koumenis, C Pintado, CC Ferrari, CG Brook, CM Ethen, CM Larsen, CS Mendes, CS Shi, D Blum-Degen, D Narendra, DG McGonagle, DH Anderson, DS Friedman, E Hetier, ET Chouchani, F Ciccia, F Martinon, F Martinon, F Pickford, F Urano, FS Giovine Di, FS Giovine di, G Boden, H Gao, H Kroeger, H Park, H Snyder, HD Ryoo, HM Gao, HM Gao, HM Hoffman, HW Virgin, I Aksentijevich, I Aksentijevich, I Allaeys, I Mitroulis, I Todd, I Todd, J Feldmann, J Harris, J Hirosumi, J Moscat, J Wu, J Yu, JA Duncan, JA Ehses, JD Rioux, JE Ramos de Carvalho, JJ Chae, JJ Hoozemans, JJ Hoozemans, JL Webb, JP Mear, JP Sherlock, JR Vingerling, JW Crabb, JY Choe, K Arima, K Cadwell, K Nakahira, KK Chung, KS McNaught, KS McNaught, KT Uysal, L Agostini, L Cantarini, L Qin, L Salvado, L Serrano-Marco, L-p Yang, LJ Dickie, LM Ittner, LV Johnson, M Gattorno, M Komatsu, M Lu, M Martinez-Vicente, M Meyer-Luehmann, M Mogi, M Mogi, M Shimazawa, M-J Kang, MC Chartier-Harlin, MC Pott Godoy, MF Gregor, MF McDermott, MG Spillantini, MG Spillantini, MH Polymeropoulos, Michael F. McDermott, MJ Turner, MJ Turner, ML DeLay, ML Huggins, MS Gorbatyuk, N Hosogai, N Mimura, N Romberg, N Yousaf, NK Sharma, NS Dangoria, P Scott, PL McGeer, PN Hawkins, Q Qiu, Q Yao, R Burgh van der, R Goldbach-Mansky, RC Chang, RC Coll, RD Jager, Richard M. Siegel, S Itagaki, S Savic, S Savic, S Xanthoulea, SL Doyle, SL Masters, SL Masters, SL Rebelo, SM Churchman, Stephanie R. Harrison, SW Canna, T Bachetti, T Bachetti, T Hara, T Ryhänen, T Saitoh, T Strowig, T Yoshizaki, T Yoshizaki, The Eye Diseases Prevalence Research, G, U Ozcan, U Ozcan, U Seifert, VT Samuel, W Pan, X Zhang, Y Liu, Y Shi, Y Zhong, Y-H Youm, ZV Wang   +162 more
core   +1 more source

Long-Term Outcomes of Behçet’s Syndrome-Related Uveitis: A Monocentric Italian Experience

Mediators of Inflammation, 2020
Objectives. To examine demographic and clinical characteristics and long-term visual outcome in a cohort of Italian patients affected by Behçet’s uveitis (BU). Materials and Methods.
Jurgen Sota, Luca Cantarini, Antonio Vitale, Arianna Sgheri, Stefano Gentileschi, Valeria Caggiano, Viviana Gelardi, Bruno Frediani, Gian Marco Tosi, Claudia Fabiani   +9 more
doaj   +1 more source

Monogenic autoinflammatory diseases in children: single center experience with clinical, genetic, and imaging review

Insights into Imaging, 2020
Purpose 1. To review the contemporary literature and present a list of the imaging findings for patients with autoinflammatory diseases from our hospital. All these patients are found to have a genetic mutation that is responsible for their disease.
Alaa N. Alsharief, Ronald M. Laxer, Qiuyan Wang, Jennifer Stimec, Carina Man, Paul Babyn, Andrea S. Doria   +6 more
doaj   +1 more source