Results 31 to 40 of about 159,270 (192)
Autoinflammatory Diseases in Childhood
Balkan Medical Journal, 2020 Autoinflammatory diseases are characterized by recurrent fevers and clinical findings of impaired natural immunity and can involve various organ systems. The concept of autoinflammatory disease emerged after the definition of familial Mediterranean fever
Mehmet Yıldız +4 more
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MicroRNAs in Juvenile Idiopathic Arthritis: State of the Art and Future Perspectives
Biology, 2023 Juvenile Idiopathic Arthritis (JIA) represents the most common chronic pediatric arthritis in Western countries and a leading cause of disability in children.
Simone Pelassa +3 more
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Monogenic autoinflammatory diseases [PDF]
Rheumatology, 2014 During the past 15 years, a growing number of monogenic inflammatory diseases have been described and their respective responsible genes identified. The proteins encoded by these genes are involved in the regulatory pathways of inflammation and are mostly expressed in cells of the innate immune system.
Ricardo A G, Russo, Paul A, Brogan
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Spectrum of Genetic Autoinflammatory Diseases Presenting with Cutaneous Symptoms
Acta Dermato-Venereologica, 2020 Autoinflammatory diseases comprise a group of chronic disabling entities characterized by inflammation without the presence of infectious agents, auto-antibodies or antigen-specific T-cells. Many autoinflammatory diseases are caused by monogenic defects,
Hanna Bonnekoh +5 more
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Frontiers in Immunology, 2022 Autoinflammatory diseases are a group of clinical syndromes characterized by constitutive overactivation of innate immune pathways. This results in increased production of or responses to monocyte- and neutrophil-derived cytokines such as interleukin-1β (
McKella Sylvester +2 more
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Autoinflammatory diseases in Pediatrics
Archivos Argentinos de Pediatria, 2013 Monogenic autoinflammatory syndromes are caused by mutations in protein-coding genes that have a pivotal role in the regulation of the inflammatory response. Due to their genetic nature, most of these syndromes usually begin during childhood. They are clinically characterized by recurrent episodes of systemic inflammation (fever with different clinical
Silvia M, Meiorin +2 more
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Induced Pluripotent Stem Cell-Derived Monocytes/Macrophages in Autoinflammatory Diseases
Frontiers in Immunology, 2022 The concept of autoinflammation, first proposed in 1999, refers to a seemingly unprovoked episode of sterile inflammation manifesting as unexplained fever, skin rashes, and arthralgia.
Takayuki Tanaka +8 more
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Cutaneous manifestations of autoinflammatory diseases [PDF]
Rheumatology and Immunology Research, 2021 Abstract Autoinflammatory diseases (AIDs) are a heterogeneous group of disorders in which recurrent or continuous aseptic inflammation arises primarily through antigen-independent hyperactivation of the innate immune system. The skin is frequently involved with a wide variety of cutaneous manifestations, most of which are non-specific ...
Wu, Di, Shen, Min, Yao, Qingping
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Toward an Inclusive, Congruent, and Precise Definition of Autoinflammatory Diseases
Frontiers in Immunology, 2017 Autoinflammatory disease was introduced as a concept in 1999, demarcating an entirely new group of diseases in clinical, immunological, and conceptual terms.
Per Wekell +6 more
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Recommendations for the management of autoinflammatory diseases [PDF]
Annals of the Rheumatic Diseases, 2015 : Autoinflammatory diseases are characterised by fever and systemic inflammation, with potentially serious complications. Owing to the rarity of these diseases, evidence-based guidelines are lacking. In 2012, the European project Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate regimens ...
Ter Haar, Nienke M +26 more
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