Streptococcus pneumoniae, the most common cause of community-acquired pneumonia, causes severe invasive infections, including meningitis and bacteremia. The widespread use of macrolides has been reported to increase the prevalence of macrolide-resistant ...
Hisanori Domon +8 more
doaj +1 more source
Proteolysis of insulin-like growth factor binding proteins (IGFBPs) by calpain [PDF]
Calpains are non-lysosomal, Ca2+-dependent cysteine proteases, which are ubiquitously distributed across cell types and vertebrate species. The rules that govern calpain specificity have not yet been determined.
Andress +15 more
core +1 more source
A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques [PDF]
Human infection by Zika virus (ZIKV) during pregnancy can lead to vertical transmission and fetal aberrations, including microcephaly. Prophylactic administration of antibodies can diminish or prevent ZIKV infection in animal models, but whether passive ...
Agudelo, Marianna +25 more
core +2 more sources
Biochemistry Changes That Occur after Death: Potential Markers for Determining Post-Mortem Interval [PDF]
Death is likely to result in very extensive biochemical changes in all body tissues due to lack of circulating oxygen, altered enzymatic reactions, cellular degradation, and cessation of anabolic production of metabolites.
Donaldson, Andrea
core +1 more source
Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo [PDF]
Detoxification of gluten immunogenic epitopes is a promising strategy for the treatment of celiac disease. Our previous studies have shown that these epitopes can be degraded in vitro by subtilisin enzymes derived from Rothia mucilaginosa, a natural ...
Darwish, Ghassan +4 more
core +1 more source
Penicillin Amidohydrolases in Fungal Autolysis [PDF]
AbstractThe production of penicillin G and penicillin V amidohydrolases or acylases (E.C.3.5.1.11) was studied during the autolysis of filamentous fungi in a mineral medium, and in the same medium with phenoxyacetic acid as inducer. In all the studied fungi, enzymes showing penicillin G and penicillin V amidohydrolase activities were found.
C, Alfonso, L, Cribeiro, F, Reyes
openaire +2 more sources
Chilling Stress Triggers VvAgo1-Mediated miRNA-Like RNA Biogenesis in Volvariella volvacea
In Volvariella volvacea, an important species of edible mushroom, cryogenic autolysis is a typical phenomenon that occurs during abnormal metabolism.
Ming Gong +11 more
doaj +1 more source
Preclinical Analysis of JAA-F11, a Specific Anti-Thomsen-Friedenreich Antibody via Immunohistochemistry and In Vivo Imaging. [PDF]
The tumor specificity of JAA-F11, a novel monoclonal antibody specific for the Thomsen-Friedenreich cancer antigen (TF-Ag-alpha linked), has been comprehensively studied by in vitro immunohistochemical (IHC) staining of human tumor and normal tissue ...
Adams, Julia +13 more
core +2 more sources
The Autolysis of Clostridium sporogenes [PDF]
SUMMARY: Washed Clostridium sporogenes lysed during storage at 2° or on incubation at 37° in various buffered salt solutions. The lysis was accompanied by a marked increase in adenosine triphosphatase activity (ATPase), due to an enzyme bound to the cytoplasmic membrane.
E, Galli, D E, Hughes
openaire +2 more sources
Kinetic Modeling and Numerical Simulation as Tools to Scale Microalgae Cell Membrane Permeabilization by Means of Pulsed Electric Fields (PEF) From Lab to Pilot Plants [PDF]
Pulsed Electric Fields (PEF) is a promising technology for the gentle and energy efficient disruption of microalgae cells such as Chlorella vulgaris.
Knappert, Justus +2 more
core +1 more source

