Results 111 to 120 of about 15,562 (187)

In vivo RFP-GFP-LC3 reporter in wild-type and Stra8-deficient testes.

, 2019
(A) Whole-mount seminiferous tubules from RFP-GFP-LC3 transgenic mouse testes in juvenile wild-type and Stra8-deficient backgrounds by confocal imaging (upper panels).
Diane Capen (6667643), Ianina C. Ferder (6667637), Ning Wang (108353), Xiaoyu Zhang (62901), Kara G. Lassen (187089), Leslie Fung (6667640), Yasuyo Ohguchi (841986), Dennis Brown (137035), Ramnik J. Xavier (153776)   +8 more
core   +1 more source

Elamipretide Rejuvenates Oocyte Quality and Restores Female Fertility During Reproductive Aging

Aging Cell, Volume 25, Issue 10, October 2026.
We reported a novel peptide therapy showing that elamipretide restores the quality of aged oocytes for fertility by coordinately boosting oocyte nuclear and cytoplasmic maturation via activation of the VEGF signaling pathway. ABSTRACT Aging represents a major contributor to the deterioration of female fertility, with oocyte quality being the central ...
Hao‐Lin Zhang, Yue Wang, Caizhu Wang, Xin Guo, Huanhua Chen, Yu‐Xuan Hou, Xuan Wu, Zi‐Jian Wu, Wen‐Lin Pan, Rui‐Jie Ma, Ping‐Shuang Lu, Jinhui Shu, Shao‐Chen Sun   +12 more
wiley   +1 more source

Ammonium chloride, an environmental pollutant, disrupts melanocyte biology through the regulation of melanosome and autophagy

Ecotoxicology and Environmental Safety
Ammonium chloride is an indoor environmental pollutant released due to industrial emissions, concrete, indoor bacteria, or other sources. In this study, we characterized molecular mechanisms of ammonium chloride-induced cell damage in melanocyte cells ...
Sae Woong Oh, Eunbi Yu, See-Hyoung Park, Kitae Kwon, Jung Hyun Lee, Heejun Ha, Gyeonghyeon Kim, Hee Seon Shin, Seokhyeon Min, Minkyung Song, Jae Youl Cho, Jongsung Lee   +11 more
doaj   +1 more source

Synaptic Proteostasis in Health and Disease

Journal of Neurochemistry, Volume 170, Issue 10, October 2026.
The localised creation and degradation of proteins at the pre and postsynaptic terminal are processes that are crucial for neuronal homeostasis. Synaptic proteostasis pathways are frequently reported as dysregulated in neurodevelopmental and neurodegenerative disorders.
Paul G. Donlin‐Asp, Emma L. Clayton
wiley   +1 more source

Electron Microscopy of autophagosomes and autolysosomes in cells expressing different levels of DRD3.

, 2016
(A) Representative electron microscopic images of two autophagosomes (AP, left panel) and an autolysosome (AL, right panel). Scale bar: 500 nm. (B) Quantification of autophagosomes and autolysosomes in CHO cells and CHO cells overexpressing GFP-DRD3-Flag.
Xin Zhang (35492), Qingsong Liu (381059), Zhiyuan Li (205620), Wenchao Wang (242659), Ulrike S. Eggert (2041642), Juanjuan Liu (384099), Xiaofei Liang (843086), Hong Wu (105254), Jing Liu (38537), Xinmiao Ji (3173772)   +9 more
core   +1 more source

CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy

, 2018
Helicobacter pylori-derived CagA, a type IV secretion system effector, plays a role as an oncogenic driver in gastric epithelial cells. However, upon delivery into gastric epithelial cells, CagA is usually degraded by macroautophagy/autophagy. Hence, the
Yoshimasa Saito (296863), Masaya Imoto (263248), Juntaro Matsuzaki (296866), Hidekazu Suzuki (105870), Hitoshi Tsugawa (296864), Makoto Suematsu (141175), Hideki Mori (1709440), Akira Sato (210501)   +7 more
core   +1 more source

Effects of Fat and Fatty Acids on the Formation of Autolysosomes in the Livers from Yellow Catfish Pelteobagrus Fulvidraco

, 2019
The autophagy-lysosome pathway, which involves many crucial genes and proteins, plays crucial roles in the maintenance of intracellular homeostasis by the degradation of damaged components.
Li-Xiang Wu, Zhi Luo, Shui-Bo Yang, Tao Zhao, Chuan-Chuan Wei   +4 more
core   +1 more source

Accumulation of intermediate structures of lysosome-dependent degradation pathways in Nrf2^−/− mice.

, 2013
At sites of BrM with abnormalities, RPE cells showed increased presence of autophagosome (A, arrowhead and F) and autolysosome (A, D and F, arrow), swollen mitochondria fragments next to autophagic vacuoles (A and B), undigested POS (A and C), and ...
Yan Chen (4308), Jiyang Cai (295973), Jian Wang (5901), Hans E. Grossniklaus (167806), Paul Sternberg (352466), Zhenyang Zhao (295966), Michael L. Freeman (164199)   +6 more
core   +1 more source

Model of autophagic-mediated UBC9 degradation and its impairment by HPV16 E6/E7 in HKs.

, 2017
(A) In normal conditions, UBC9 protein expression is retained at physiological levels by basal autophagy in HKs. (B) However, the presence of HPV16 E6/E7 impairs autophagosome-autolysosome fusion.
Claudia Miccolo (377902), Massimo Tommasino (8382), Chiara Casadio (3808876), Carlo Tacchetti (252415), Marta Tagliabue (3808885), Fausto Chiesa (3808888), Fausto Maffini (3808870), Michael Pawlita (77239), Susanna Chiocca (119134), Domenico Mattoscio (3808882), Tarik Gheit (348201), Francesca De Lorenzi (3808867), Mohssen Ansarin (3808873), Andrea Raimondi (749423), Viviana E. Galimberti (3808879)   +14 more
core   +1 more source

Ghrelin improves small intestinal barrier damage in sepsis by promoting miR-143/ATG2B-mediated autophagy.

PLoS ONE
Intestinal barrier damage is crucial for the development of sepsis. Ghrelin (GHS) can restore intestinal barrier function. However, the mechanisms of GHS on intestinal barrier damage in sepsis remain unclear.
Jingquan Liu, Kai Shi, Hanhui Cai, Zihao Zheng, Bin Fan, Xianghong Yang, Ziqiang Shao   +6 more
doaj   +1 more source