Results 141 to 150 of about 17,929 (235)

Telomere Dysfunction and Proteostasis Decline Define Distinct Pathways of Cellular Senescence in the Human Respiratory Tract

Aging Cell, Volume 25, Issue 5, May 2026.
Telomere shortening occurs with age in the respiratory epithelium, but telomere dysfunction‐induced foci (TIF) accumulate only late in life. In contrast, proteostasis decline emerges earlier and correlates with functional impairment, suggesting it may be a primary driver of cellular senescence during physiological aging.
Céline Coquette, Kamar Bouchoucha, Manon Mahieu, Stijn E. Verleden, Axelle Loriot, Kevin Norris, Duncan M. Baird, Amélie Derumier, Delphine Hoton, Laurens De Sadeleer, Arno Vanstapel, Bart M. Vanaudenaerde, Maëlle de Ville de Goyet, Bénédicte Brichard, Antoine Froidure, Wim Wuyts, Jan Van Slambrouck, Laurens J. Ceulemans, William Trigaux, Caroline Huart, Anabelle Decottignies   +20 more
wiley   +1 more source

A Decline in Follicle Cell Function Is a Major Driver of Drosophila Ovarian Aging

Aging Cell, Volume 25, Issue 5, May 2026.
Aging drives a progressive accumulation of defects in somatic follicle cells of the Drosophila ovary. These defects are accompanied by reduced tissue and genome integrity, altered transcriptional profiles, and disrupted germ‐soma coordination. Targeted overexpression of Atg8a in a subset of follicle cells mitigates these defects and preserves ...
Emily A. Wolfgram, Todd G. Nystul
wiley   +1 more source

Autolysosomal Membrane-associated Betaine Homocysteine Methyltransferase [PDF]

Journal of Biological Chemistry, 1999
Takashi Ueno, Kazumi Ishidoh, Reiko Mineki, Isei Tanida, Kimie Murayama, Motoni Kadowaki, Eiki Kominami   +6 more
openaire   +1 more source

Exosomal Non‐Coding RNAs in Gastrointestinal Cancer Drug Resistance: A Systematic Review of Emerging Mechanisms and Clinical Implications

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Gastrointestinal (GI) tumours are one of the most prevalent cancers globally. Even with normal GI function, individuals may develop neoplasms, highlighting the need to better understand the underlying causes of tumorigenesis. The emergence of tumour drug resistance represents the main reason for the failure of drug treatment; thus, it is ...
Mohsen Sharif‐zak, Zahra Sadeghloo, Fateme Binayi, Stefania Nobili, Sara Ashtari, Amir Sadeghi, Nayeralsadat Fatemi   +6 more
wiley   +1 more source

Ammonium chloride, an environmental pollutant, disrupts melanocyte biology through the regulation of melanosome and autophagy

Ecotoxicology and Environmental Safety
Ammonium chloride is an indoor environmental pollutant released due to industrial emissions, concrete, indoor bacteria, or other sources. In this study, we characterized molecular mechanisms of ammonium chloride-induced cell damage in melanocyte cells ...
Sae Woong Oh, Eunbi Yu, See-Hyoung Park, Kitae Kwon, Jung Hyun Lee, Heejun Ha, Gyeonghyeon Kim, Hee Seon Shin, Seokhyeon Min, Minkyung Song, Jae Youl Cho, Jongsung Lee   +11 more
doaj   +1 more source

Autophagy, physiology and cell pathology [PDF]

, 2013
Autophagy plays an important role in human pathologies, such as myopathies and neurodegenerative diseases. Moreover, metabolic disease processes such as diabetes and pancreatitis, as well as tumor cells and cancer chemotherapy, activate autophagy ...
Vaccaro, Maria Ines
core  

Cathepsin B-mediated autolysosome efflux and cell death [PDF]

, 2010
Autophagy is a vesicular system which is a lysosomal degradation pathway found in organisms ranging from yeast to mammals. To date, extensive studies have unraveled the mechanism of autophagy biogenesis and more than thirty autophagy related (ATG) genes have been identified. However, detailed molecular mechanisms of autophagic process have not yet been
openaire  

Lysosomal capturing of cytoplasmic injected nanoparticles by autophagy: an additional barrier to non viral gene delivery [PDF]

, 2014
Braeckmans, Kevin, De Smedt, Stefaan, Klumperman, Judith, Oorschot, Viola, Remaut, Katrien   +4 more
core   +1 more source

How to be young at heart? miR-22 as a potential therapeutic target to boost autophagy and protect the old myocardium [PDF]

, 2017
DE FALCO, Elena, Frati, Giacomo, Sadoshima, J., Sciarretta, Sebastiano   +3 more
core   +2 more sources

Emerging evidence for beneficial macrophage functions in atherosclerosis and obesity-induced insulin resistance [PDF]

, 2016

core   +1 more source