Results 211 to 220 of about 17,929 (235)

Autolysosomal acidification failure as a primary driver of Alzheimer disease pathogenesis

Autophagy, 2022
Genetic evidence has increasingly linked lysosome dysfunction to an impaired autophagy-lysosomal pathway (ALP) flux in Alzheimer disease (AD) although the relationship of these abnormalities to other pathologies is unclear. In our recent investigation on the origin of impaired autophagic flux in AD, we established the critical early role of defective ...
Ju-Hyun Lee, Ralph A. Nixon
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Ultrastructural studies on autolysosomes in rat hepatocytes after leupeptin treatment

Experimental Cell Research, 1983
We have studied the morphological alterations of the lysosomal compartment in rat hepatocytes following intraperitoneal administration of leupeptin, using electron microscopy and cytochemical techniques. At 30 min after the injection, autophagic vacuoles (autophagosomes and autolysosomes), containing cytoplasmic organelles, increased in number in the ...
T, Ishikawa, K, Furuno, K, Kato
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A High‐Contrast Autolysosome Probe for Detecting Interaction between Autophagosomes and Autolysosomes in Mitophagy^†

Chinese Journal of Chemistry
Comprehensive SummaryAutophagy is a multi‐step cell metabolism process in which cells remove damaged and unwanted materials. During autophagy, autophagosomes fuse with lysosomes to form autophagosomes. Autophagosomal membrane components are recycled from autolysosomes through the autophagosomal components recycling (ACR), while lysosomal components ...
Weihua Wang, Chu Han, Shengjie Xie, Zisong Cong, Zixuan Yang, Yuxin Feng, Limin Xiang, Heng Song   +7 more
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Measurement of Autolysosomal pH by Dual-Wavelength Ratio Imaging

2017
Cellular components sequestered by autophagosomes during macroautophagy must be degraded and their components recycled in order to maintain homeostasis. To this end cells orchestrate the fusion of autophagosomes with lysosomes, degradative organelles that are rich in hydrolases.
A, Saric, S, Grinstein, S A, Freeman
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GORASP2 promotes phagophore closure and autophagosome maturation into autolysosomes

Autophagy
As the central hub of the secretory pathway, the Golgi apparatus plays a crucial role in maintaining cellular homeostasis in response to stresses. Recent studies have revealed the involvement of the Golgi tether, GORASP2, in facilitating autophagosome-lysosome fusion by connecting LC3-II and LAMP2 during nutrient starvation.
Yusheng Xing, Lei Huang, Yannan Jian, Zhenqian Zhang, Xiaodan Zhao, Xing Zhang, Tingting Fu, Yue Zhang, Yijie Wang, Xiaoyan Zhang   +9 more
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Persistency of Enlarged Autolysosomes Underscores Nanoparticle‐Induced Autophagy in Hepatocytes

Small, 2016
The diverse biological effects of nanomaterials form the basis for their applications in biomedicine but also cause safety issues. Induction of autophagy is a cellular response after nanoparticles exposure. It may be beneficial in some circumstances, yet autophagy‐mediated toxicity raises an alarming concern.
Ji-Qian, Zhang, Wei, Zhou, Sha-Sha, Zhu, Jun, Lin, Peng-Fei, Wei, Fen-Fen, Li, Pei-Pei, Jin, Han, Yao, Yun-Jiao, Zhang, Yi, Hu, Yi-Ming, Liu, Ming, Chen, Zheng-Quan, Li, Xue-Sheng, Liu, Li, Bai, Long-Ping, Wen   +15 more
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Dihydroceramide desaturase modulates autolysosome maturation and ameliorates CRB1 retinopathy

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Variants in the CRB1 gene cause retinal degeneration and subsequent vision impairment in patients of retinitis pigmentosa (RP). No treatments are currently available to cure or impede the progression of CRB1-associated retinopathy. Previous studies have revealed alterations in the endolysosomal systems and autophagy in the absence of CRB1, but their ...
Fei-Yang Tzou, Pei-Huan Chuang, Chia-Heng Hsu, Chih-Hsuan Wu, Yi Hsiao, Chung-Chih Liu, Yu-Lian Yu, Yu-Han Yeh, Chih-Wei Lin, Chih-Chaing Chan, Shu-Yi Huang   +10 more
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Inhibition of autolysosome formation in host autophagy by Trypanosoma cruzi infection

Acta Tropica, 2017
Autophagy has emerged as an essential component of the defense system against intracellular pathogens. We demonstrated that Trypanosoma cruzi, an intracellular protozoan parasite, was not eliminated by the host's autophagic machinery despite exposure to the host cell cytoplasm.
Yoko, Onizuka, Chiyuki, Takahashi, Ami, Uematsu, Shoko, Shinjo, Eri, Seto, Junko, Nakajima-Shimada   +5 more
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PtdIns4P exchange at endoplasmic reticulum-autolysosome contacts is essential for autophagy and neuronal homeostasis

Autophagy, 2023
Chao Tong
exaly  

Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

Nature Neuroscience, 2022
Ju-hyun Lee, Dun-Sheng Yang, Christopher Goulbourne   +2 more
exaly