Results 41 to 50 of about 2,057,707 (306)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Automated single-slide staining system [PDF]

, 1974
Apparatus developed to Gram-stain single slides automatically is flexible enough to accommodate other types of staining procedures. Method frees operator and eliminates necessity for subjective evaluations as to length of staining or decolorizing ...
Mills, S. M., Wilkins, J. R.
core   +1 more source

Automation and data processing with the immucor Galileo (R) system in a university blood bank [PDF]

, 2007
Background: The implementation of automated techniques improves the workflow and quality of immuno-hematological results. The workflows of our university blood bank were reviewed during the implementation of an automated immunohematological testing ...
Brown MR, Delamaire M, Dixon SR, Geisen C, Georg Wittmann, Henneman EA, Josef Frank, Kretschmer V, Michael Spannagl, Offergeld R., Sandler SG, Stainsby D, Wagar EA, Weisbach V, Weisbach V, Weisbach V, Wolfgang Schramm   +16 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Performance Analysis of Different Machine Learning Algorithms for Predictive Maintenance

Al-Khawarizmi Engineering Journal
This research offers an extensive study of different machine learning issues for predictive maintenance applications for motor condition ranging from AC motors.
Noor A. Mohammed, Osamah F. Abdulateef , Ali H. Hamad, Oday I. Abdullah   +3 more
doaj   +1 more source

COMPARATIVE CHARACTERISTIC OF MEANS OF AUTOMATED CHECK OF THE CORRECTNESS OF WRITING OF SQL REQUESTS

Вестник СибАДИ, 2017
The article presents an analysis of resources that can be used to test users who study the SQL language. Also, the article describes plan and result of the attack on web applications for learning the SQL language.
Z. V. Semenova, S. A. Lyubich, A. G Kuznetsov, P. A. Mal’tsev   +3 more
doaj   +1 more source

Automated Data Management Information System (ADMIS) [PDF]

, 1974
ADMIS stores and controls data and documents associated with manned space flight effort. System contains all data oriented toward a specific document; it is primary source of reports generated by the system.
Blackstone, C., Buehler, D., Dunn, D., Feeley, J., Hoffiditz, T., Pratt, L., Rose, J., Smithson, M., Sullivan, E., Whitlock, J.   +9 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Verification of a 3-Degree-of-freedom Bus Handling Model Due to Steering Wheel Input

Jurnal Ilmiah SINERGI
This paper discusses about the development and modeling of a 3-DOF (Degrees of Freedom) bus handling model in response to steering wheel input from the driver. It includes all the relevant mathematical equations.
Muhammad Akhmal Hakima, Vimal Rau Aparowa, Zulkiffli Abd Kadir, Novita Sakundarini, Khisbullah Hudha, Noor Hafizah Amer   +5 more
doaj   +1 more source