Results 41 to 50 of about 27,781 (218)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Bayesian learning from multi-way EEG feedback for robot navigation and target identification
Scientific Reports, 2023 Many brain-computer interfaces require a high mental workload. Recent research has shown that this could be greatly alleviated through machine learning, inferring user intentions via reactive brain responses.
Christopher Wirth +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Game theoretical inference of human behavior in social networks
Nature Communications, 2019 Based on a strategic network formation model, the authors develop game-theoretical and statistical methods to infer individuals’ incentives in complex social networks, and validate their findings in real-world, historical data sets.
Nicolò Pagan, Florian Dörfler
doaj +1 more source
The AMIRO Social Robotics Framework: Deployment and Evaluation on the Pepper Robot
Sensors, 2020 Recent studies in social robotics show that it can provide economic efficiency and growth in domains such as retail, entertainment, and active and assisted living (AAL).
Alexandra Ștefania Ghiță +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Design and Practical Evaluation of Robust Model Predictive Wind Turbine Control
Wind EnergyWind energy is one of the main renewable energy sources in the current energy transition. Due to ever more and ever larger wind turbines (WT), the requirements for WT operation become more complex.
Andreas Klein +6 more
doaj +1 more source
Overview of Electric Propulsion Motor Research for EVTOL
Engineering ProceedingsElectric aviation is the future development direction of aviation industry technology. Electric vertical take-off and landing aircraft(eVTOL) is an important carrier of electric aviation, whose technology research and development, processing and ...
Xiaopeng Zhao +4 more
doaj +1 more source