Results 91 to 100 of about 210,069 (312)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
ENUMERATION AND DECIDABLE PROPERTIES OF AUTOMATIC SEQUENCES [PDF]
International Journal of Foundations of Computer Science, 2011 We show that various aspects of k-automatic sequences — such as having an unbordered factor of length n — are both decidable and effectively enumerable. As a consequence it follows that many related sequences are either k-automatic or k-regular. These include many sequences previously studied in the literature, such as the recurrence function, the ...
Charlier, Emilie +2 more
openaire +4 more sources
Knowing what to respond in the future does not cancel the influence of past events. [PDF]
PLoS ONE, 2009 Everyday tasks seldom involve isolate actions but sequences of them. We can see whether previous actions influence the current one by exploring the response time to controlled sequences of stimuli.
Elisabet Tubau, Joan López-Moliner
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Limit sets of automatic sequences
Advances in Mathematics, 2003 The authors study the limit sets of multidimensional automatic sequences. For a finite set with a distinguished element \(s_0\), consider an \(\ell\)-dimensional sequence \(f\) in \(S^{\mathbb{N}^\ell}\). A sequence \((t_n)\in\mathbb{N}^{\mathbb{N}}\) is a scaling sequence, if \(({1\over t_n} X(f,t_n))\) is a Cauchy sequence with respect to the ...
Barbé, A, von Haeseler, F
openaire +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Segmentation of Pathology in Tumor-Diseased Brains
Journal of Engineering and Sustainable Development, 2008 Automatic segmentation of multiple sclerosis lesions in magnetic resonance images remains a challenging task. In this study, we present a fully automatic method to extract lesions from multi-sequence MRI (T1, T2, T2 FLAIR, Proton Density) within an ...
Mohammed Hatim Khdair
doaj
, 2011 Recently, manual observation sequence has been gradually replaced by automatic observation sequence. The difference between manual observation sequence and automatic observation sequence is somewhat inevitable. This challenges the the homogeneity and the
Ju Jie Wang +3 more
core +1 more source
A review on assembly sequence planning and assembly line balancing optimisation using soft computing approaches [PDF]
, 2011 Assembly optimisation activities occur across development and production stages of manufacturing goods. Assembly Sequence Planning (ASP) and Assembly Line Balancing (ALB) problems are among the assembly optimisation.
Tiwari, Ashutosh +5 more
core +1 more source