Results 61 to 70 of about 1,559,211 (330)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Optimized Hierarchical Sliding Mode Control for the Swing-Up and Stabilization of a Rotary Inverted Pendulum

Automation
This paper presents a study on controlling a rotary inverted pendulum (RIP) system using a hierarchical sliding mode control (HSMC) approach. The objective is to swing up and stabilize the pendulum at a desired position.
Duc-Binh Pham, Quy-Thinh Dao, Thi-Van-Anh Nguyen   +2 more
doaj   +1 more source

Development and Performance Measurement of an Affordable Unmanned Surface Vehicle (USV)

Automation, 2022
Indonesia is a maritime country that has vast coastal resources and biodiversity. To support the Indonesian maritime program, a topography mapping tool is needed. The ideal topography mapping tool is the Unmanned Surface Vehicle (USV).
Joga Dharma Setiawan, Muhammad Aldi Septiawan, Mochammad Ariyanto, Wahyu Caesarendra, M. Munadi, Sabri Alimi, Maciej Sulowicz   +6 more
doaj   +1 more source

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

Accelerated Transfer Learning for Cooperative Transportation Formation Change via SDPA-MAPPO (Scaled Dot Product Attention-Multi-Agent Proximal Policy Optimization)

Automation
A method for cooperative transportation, which required formation change in a traveling environment, is gaining interest. Deep reinforcement learning is used in formation changes for multi-robot cases.
Almira Budiyanto, Keisuke Azetsu, Nobutomo Matsunaga   +2 more
doaj   +1 more source

Phase Preserving Balanced Truncation for Order Reduction of Positive Real Systems

Automation, 2022
This paper presents a new passivity-preserving order reduction method for linear time-invariant passive systems, which are also called positive real (PR) systems, with the aid of the balanced truncation (BT) method.
Zeinab Salehi, Paknoosh Karimaghaee, Shabnam Salehi, Mohammad-Hassan Khooban   +3 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The Stability of the Systems with Command Saturation, Command Delay, and State Delay

Automation, 2022
This article presents the study of the stability of single-input and multiple-input systems with point or distributed state delay and input delay and input saturation.
Marcel Nicola
doaj   +1 more source

Automotive automation: Investigating the impact on drivers' mental workload [PDF]

, 1997
Recent advances in technology have meant that an increasing number of vehicle driving tasks are becoming automated. Such automation poses new problems for the ergonomist.
Stanton, N A, Young, M S
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source