Results 71 to 80 of about 243,371 (302)

Evaluation of a standard provision versus an autonomy promotive exercise referral programme: rationale and study design [PDF]

, 2009
Background The National Institute of Clinical Excellence in the UK has recommended that the effectiveness of ongoing exercise referral schemes to promote physical activity should be examined in research trials.
Lodhia, R., Mutrie Nanette, Lodhia, Rekha, Eves, Frank F., Williams, Geoffrey C., Duda Joan L, Eves Frank F, Williams, GC, Eves, F., Kate Jolly, Mutrie, N., Ntoumanis, Nikos, Williams Geoffrey C, Rouse, Peter C., Jolly, Kate, Daley, A., Rouse, Peter, Jolly, Catherine; id_orcid, Rouse, Peter C, Amanda Daley, Lodhia Rekha, Eves, Francis, Eves, Frank F, Duda, Joan L., Duda, J., Williams, G., Williams, Geoffrey C, Frank F Eves, Mutrie, N, Joan L Duda, Peter C Rouse, Daley Amanda, Daley, Amanda, Ntoumanis, Nikolaos; id_orcid, Jolly Kate, Rouse, P., Mutrie, Nanette, Geoffrey C Williams, Duda, Joan; id_orcid, Ntoumanis Nikos, Nanette Mutrie, Rekha Lodhia, Rouse Peter C, Nikos Ntoumanis, Duda, Joan L, Jolly, K.   +45 more
core   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Benefits of teaching styles and student-centred methodologies in Physical Education

E-balonmano.com: Revista de Ciencias del Deporte, 2018
The competence-based approach in education required a modification of the teaching performance, promoting the use of active and student-centred methodologies. The didactics of Physical Education has a previous theoretical framework that conceptualizes on
Jorge Agustín Zapatero Ayuso
doaj  

Autonomy in Engineer Support

Obrana a strategie (Defence & Strategy)
This paper analyses the role of autonomy in engineer support within the Czech Armed Forces (CAF), with a particular focus on its strategic and modernisation implications. While autonomy has become a critical dimension of contemporary defence capabilities, no existing strategic or operational document in the Czech Republic explicitly addresses the ...
Martin Sedláček, Michal Bilina, Petr Demel   +2 more
openaire   +1 more source

Making or Breaking the Republic of Moldova? The Autonomy of Gagauzia. EDAP 2/2013 [PDF]

, 2013
This article describes the process of self-determination and the creation of a territorial autonomy of the Gagauz people in the Republic of Moldova. It also analyses the situation in the autonomy after the change of government in Chisinau in 2009 and ...
Wöber, Siegfried
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Living Longer: Age Retardation and Autonomy

, 2009
Research into human ageing is a growing field of research with two central foci: geriatric medicine works to reduce the incidence and severity of age-related diseases and disabilities by devising adequate therapeutic and preventive strategies.
Hildt, Elisabeth
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source