Results 111 to 120 of about 1,007,449 (349)

The aberrant expression of the mesenchymal variant of FGFR2 in the epithelial context inhibits autophagy [PDF]

, 2019
Signaling of the epithelial splice variant of fibroblast growth factor receptor 2 (FGFR2b) triggers both differentiation and autophagy, while the aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells induces impaired differentiation ...
Belleudi, Francesca, Nanni, Monica, Persechino, Flavia, Ranieri, Danilo, Torrisi, Maria Rosaria   +4 more
core   +1 more source

Autophagic flux response and glioblastoma sensitivity to radiation

Cancer Biology & Medicine, 2018
Glioblastoma is the most common primary brain tumor in adults and one of the most lethal human tumors. It constitutes a unique non-metastasizing human tumor model with high resistance to radiotherapy and chemotherapy. The current study investigates the association between autophagic flux and glioblastoma cell resistance.The expression kinetics of ...
Achilleas G. Mitrakas, Dimitra Kalamida, Alexandra Giatromanolaki, Stamatia Pouliliou, Avgi Tsolou, Rafail Kyranas, Michael I. Koukourakis   +6 more
openaire   +3 more sources

Snazarus and its human ortholog SNX25 modulate autophagic flux

Journal of Cell Science, 2021
ABSTRACT Macroautophagy, the degradation and recycling of cytosolic components in the lysosome, is an important cellular mechanism. It is a membrane-mediated process that is linked to vesicular trafficking events. The sorting nexin (SNX) protein family controls the sorting of a large array of cargoes, and various SNXs impact autophagy ...
Annie Lauzier, Marie-France Bossanyi, Raphaëlle Larcher, Sonya Nassari, Rupali Ugrankar, W. Mike Henne, Steve Jean   +6 more
openaire   +2 more sources

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Cell type-specific autophagy in human leukocytes: signatures of aging, sex, and nutrient restriction

Autophagy Reports
Macroautophagy (referred to here as autophagy) is thought to play a critical role in aging and age-related disease, making it a priority for development of targeted human therapies. We developed a flow cytometry-based method to measure autophagic flux in
Linh VP Dang, Timothy J Sargeant
doaj   +1 more source

CD38 Causes Autophagic Flux Inhibition and Cardiac Dysfunction Through a Transcriptional Inhibition Pathway Under Hypoxia/Ischemia Conditions

Frontiers in Cell and Developmental Biology, 2020
Induced autophagy is protective against myocardial hypoxia/ischemia (H/I) injury, but evidence regarding the extent of autophagic clearance under H/I and the molecular mechanisms that influence autophagic flux has scarcely been presented. Here, we report
Xingyue Zhang, Xingyue Zhang, Lingfei Li, Lingfei Li, Qiong Zhang, Qiong Zhang, Qinglin Wei, Jiezhi Lin, Jiezhi Lin, Jiezhi Jia, Jiezhi Jia, Junhui Zhang, Junhui Zhang, Tiantian Yan, Yanling Lv, Yanling Lv, Xupin Jiang, Xupin Jiang, Peng Zhang, Peng Zhang, Huapei Song, Huapei Song, Dongxia Zhang, Dongxia Zhang, Yuesheng Huang, Yuesheng Huang, Yuesheng Huang   +26 more
doaj   +1 more source

Quantitative Analysis of Autophagic Flux by Ratiometric pH-Imaging of Autophagic Intermediates [PDF]

Biophysical Journal, 2016
Although numerous techniques have been developed to monitor autophagy to probe its cellular functions, these methods can’t evaluate in sufficient detail the autophagy process, and suffer limitations from complex experimental setups and/or systematic errors.
Maulucci, Giuseppe, Chiarpotto, Michela, Papi, Massimiliano, Palmieri, Valentina, Ciasca, Gabriele, Carmela Lauriola, Maria, Samengo, Daniela, Pani, Giovambattista, De Spirito, Marco   +8 more
openaire   +1 more source

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source

Autophagic flux induced by graphene oxide has a neuroprotective effect against human prion protein fragments

International Journal of Nanomedicine, 2017
Jae-Kyo Jeong,1 You-Jin Lee,1 Seung Yol Jeong,2,3 Sooyeon Jeong,2 Geon-Woong Lee,2 Sang-Youel Park1 1Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University, Iksan, 2Nano Hybrid Technology Research Center, Korea ...
Jeong JK, Lee YJ, Jeong SY, Jeong S, Lee GW, Park SY   +5 more
doaj  

Simvastatin accelerated motoneurons death in SOD1G93A mice through inhibiting Rab7-mediated maturation of late autophagic vacuoles

Cell Death and Disease, 2021
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by motoneuron loss, for which there is currently no effective treatment. Statins, as inhibitors of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, are used as drugs
Lin Bai, Yafei Wang, Jia Huo, Shuai Li, Ya Wen, Qi Liu, Jing Yang, Yaling Liu, Rui Li   +8 more
doaj   +1 more source