Results 51 to 60 of about 1,007,449 (349)
Breast Cancer Research, 2023 The chemotherapy of triple-negative breast cancer based on doxorubicin (DOX) regimens suffers from great challenges on toxicity and autophagy raised off-target.
Zhiwen Cao +10 more
doaj +1 more source
Oncology Letters, 2021 The sporoderm-broken spores of Ganoderma lucidum (G. lucidum) polysaccharide (BSGLP) have been demonstrated to inhibit carcinogenesis in several types of cancer.
Jiaying Zhong +9 more
semanticscholar +1 more source
Lipid storage and autophagy in melanoma cancer cells [PDF]
, 2017 Cancer stem cells (CSC) represent a key cellular subpopulation controlling biological features such as cancer progression in all cancer types. By using melanospheres established from human melanoma patients, we compared less differentiated melanosphere ...
Cordella, Martina +9 more
core +2 more sources
Flow Cytometric Analyses of Autophagic Activity using LC3-GFP fluorescence
Bio-Protocol, 2014 Flow cytometry allows very sensitive and reliable high-throughput analysis of autophagic flux. This methodology permits to screen cells in flow and capture multi-component images.
Metodi Stankov +3 more
doaj +1 more source
Using cultured canine cardiac slices to model the autophagic flux with doxorubicin.
PLoS ONE, 2023 Chemotherapy-induced impairment of autophagy is implicated in cardiac toxicity induced by anti-cancer drugs. Imperfect translation from rodent models and lack of in vitro models of toxicity has limited investigation of autophagic flux dysregulation ...
Asma Boukhalfa +11 more
doaj +1 more source
Journal of Cellular and Molecular Medicine, 2021 Helicobacter pylori (H. pylori) is the strong risk factor for a series of gastric pathological changes. Persistent colonization of H. pylori leading to chronic infection is responsible for gastritis and malignancy.
Xin Wang +6 more
semanticscholar +1 more source
Three consecutive cytosolic glycolysis enzymes modulate autophagic flux
Plant Physiology, 2023 Abstract Autophagy serves as an important recycling route for the growth and survival of eukaryotic organisms in nutrient-deficient conditions. Since starvation induces massive changes in the metabolic flux that are coordinated by key metabolic enzymes, specific processing steps of autophagy may be linked with metabolic flux-monitoring ...
Du-Hwa Lee +6 more
openaire +2 more sources
Diosmin Inhibits Glioblastoma Growth through Inhibition of Autophagic Flux [PDF]
International Journal of Molecular Sciences, 2021 Diosmin, a natural flavone glycoside acquired through dehydrogenation of the analogous flavanone glycoside hesperidin, is plentiful in many citrus fruits. Glioblastoma multiforme (GBM) is the most malignant primary brain tumor; the average survival time of GBM patients is less than 18 months after standard treatment. The present study demonstrated that
Yung-Lung Chang +6 more
openaire +2 more sources
Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy [PDF]
, 2015 Spinal and bulbar muscular atrophy (SBMA) is characterized by loss of motoneurons and sensory neurons, accompanied by atrophy of muscle cells. SBMA is due to an androgen receptor containing a polyglutamine tract (ARpolyQ) that misfolds and aggregates ...
Aggarwal, Tanya +15 more
core +2 more sources
Regulation of Autophagic Flux by the 20S Proteasome [PDF]
Cell Chemical Biology, 2019 The proteolytic arm of the protein homeostasis network is maintained by both the ubiquitin-proteasome system (UPS) and autophagy. A well-balanced crosstalk between the two catabolic pathways ensures energy-efficient maintenance of cellular function. Our current understanding of the crosstalk between the UPS and autophagy is centered around substrate ...
Evert Njomen, Jetze J. Tepe
openaire +2 more sources