Results 71 to 80 of about 1,007,449 (349)
Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress [PDF]
, 2019 York University ...
Jahng, James Won Suk +4 more
core +2 more sources
Glutamate induces autophagy via the two-pore channels in neural cells [PDF]
, 2016 NAADP (nicotinic acid adenine dinucleotide phosphate) has been proposed as a second messenger for glutamate in neuronal and glial cells via the activation of the lysosomal Ca2+ channels TPC1 and TPC2.
+11 more
core +4 more sources
Vps4a Regulates Autophagic Flux to Prevent Hypertrophic Cardiomyopathy
International Journal of Molecular Sciences, 2023 Autophagy has stabilizing functions for cardiomyocytes. Recent studies indicate that an impairment in the autophagy pathway can seriously affect morphology and function, potentially leading to heart failure. However, the role and the underlying mechanism of the endosomal sorting complex required for transport (ESCRT) family protein, in particular the ...
Huang, Xiaozhi +4 more
openaire +2 more sources
Frontiers in Pharmacology, 2021 Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory damage and cognitive dysfunction. Studies have shown that defective autophagic flux is associated with neuronal dysfunction.
Zhenwan Li +3 more
doaj +1 more source
The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux [PDF]
Scientific Reports, 2019 AbstractAntidepressants are commonly prescribed psychotropic substances for the symptomatic treatment of mood disorders. Their primary mechanism of action is the modulation of neurotransmission and the consequent accumulation of monoamines, such as serotonin and noradrenaline.
Federica Cavaliere +10 more
openaire +3 more sources
Acta Biochimica et Biophysica Sinica, 2022 Lipotoxicity has been shown to induce the loss of functional β-cell mass and lead to type 2 diabetes, but the mechanism remains unknown. In this study, we aim to explore the role of secretagogin (SCGN) in lipotoxicity-induced β-cell injury.
Lv Ying +8 more
doaj +1 more source
TheranosticsRationale: Autophagy dysregulation is known to be a mechanism of doxorubicin (DOX)-induced cardiotoxicity (DIC). Mitochondrial-Endoplasmic Reticulum Contacts (MERCs) are where autophagy initiates and autophagosomes form.
Weibin He +9 more
semanticscholar +1 more source
CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux
Autophagy, 2021 MLKL (mixed lineage kinase domain like pseudokinase) is a well-known core component of necrosome that executes necroptotic cell death upon phosphorylation by RIPK3 (receptor interacting serine/threonine kinase 3).
Q. Zhan +10 more
semanticscholar +1 more source
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells [PDF]
, 2018 Sirtuin 6 (SIRT6) is a member of the NAD+-dependent class III deacetylase sirtuin family, which plays a key role in cancer by controlling transcription, genome stability, telomere integrity, DNA repair, and autophagy.
Annamaria Biroccio, And +13 more
core +2 more sources
Rab7b modulates autophagic flux by interacting with Atg4B [PDF]
EMBO reports, 2017 Autophagy (macroautophagy) is a highly conserved eukaryotic degradation pathway in which cytosolic components and organelles are sequestered by specialized autophagic membranes and degraded through the lysosomal system. The autophagic pathway maintains basal cellular homeostasis and helps cells adapt during stress; thus, defects in autophagy can cause ...
Ingrid Kjos +9 more
openaire +4 more sources