Results 41 to 50 of about 58,150 (299)
Leishmania proteins associated with host-cell autophagosomes.
, 2023 Leishmania proteins associated with host-cell autophagosomes.
Kyung-Mee Moon (685480) +5 more
core +1 more source
Advanced Science, 2023 Ferroptosis plays an essential role in the development of diabetes and its complications, suggesting potential therapeutic strategies targeting ferroptosis.
Shengnan Cui +13 more
doaj +1 more source
Quantitative 3D correlative light and electron microscopy of organelle association during autophagy
Cell Structure and Function, 2022 In macroautophagy, disk-shaped double-membrane structures called phagophores elongate to form cup-shaped structures, becoming autophagosomes upon closure. These autophagosomes then fuse with lysosomes to become autolysosomes and degrade engulfed material.
Satoru Takahashi +3 more
doaj +1 more source
Scaffolding the expansion of autophagosomes [PDF]
Autophagy, 2014 The conjugation of the small ubiquitin (Ub)-like protein Atg8 to autophagic membranes is a key step during the expansion of phagophores. This reaction is driven by 2 interconnected Ub-like conjugation systems. The second system conjugates the Ub-like protein Atg12 to Atg5.
Kaufmann, A., Wollert, T.
openaire +3 more sources
Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity
Cell Reports, 2017 Consumption of a hypercaloric diet upregulates microglial innate immune reactivity along with a higher expression of lipoprotein lipase (Lpl) within the reactive microglia in the mouse brain.
Yuanqing Gao +15 more
doaj +1 more source
Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes
Cell, 2021 The biogenesis of mammalian autophagosomes remains to be fully defined. Here, we used cellular and in vitro membrane fusion analyses to show that autophagosomes are formed from a hitherto unappreciated hybrid membrane compartment. The autophagic precursors emerge through fusion of FIP200 vesicles, derived from the cis-Golgi, with endosomally derived ...
Kumar, Suresh +21 more
openaire +5 more sources
Dendritic distribution of autophagosomes underlies pathway-selective induction of LTD
, 2023 Summary: The mechanism of long-term depression (LTD), a cellular substrate for learning, memory, and behavioral flexibility, is extensively studied in Schaffer collateral (SC) synapses, with inhibition of autophagy identified as a key factor.
Kevin M. Keary, III +3 more
core +1 more source
The Multivesicular Body and Autophagosome Pathways in Plants
Frontiers in Plant Science, 2018 In eukaryotic cells, the endomembrane system consists of multiple membrane-bound organelles, which play essential roles in the precise transportation of various cargo proteins.
Yong Cui +10 more
doaj +1 more source
Measuring autophagosome flux [PDF]
Autophagy, 2018 Macroautophagy/autophagy is a proteolytic pathway that is involved in both bulk degradation of cytoplasmic proteins as well as in selective degradation of cytoplasmic organelles. Autophagic flux is often defined as a measure of autophagic degradation activity, and many techniques exist to assess autophagic flux. Although these techniques have generated
Andre du Toit +3 more
openaire +2 more sources
Autophagy: A Forty-Year Search for a Missing Membrane Source
, 2006 Autophagy is the major self-degradative process in eukaryotic cells, with fundamental roles in cellular and organismal homeostasis, and is involved in many developmental and pathological situations.
Juhasz Gabor +5 more
core +1 more source