Results 31 to 40 of about 58,150 (299)

Autophagosome-Lysosome Fusion

Journal of Molecular Biology, 2020
Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during which selected cellular components are transported to and broken down within lysosomes. The process starts with the capture of unnecessary material into autophagosomes, which is followed by autophagosome-lysosome fusion to generate autolysosomes that degrade the ...
Lőrincz, Péter, Juhász, Gábor
openaire   +4 more sources

Dynamics of Autophagosome Formation [PDF]

Plant Physiology, 2017
Environmental stress activates autophagy and leads to autophagosome formation at the endoplasmic reticulum.
Junmarie Soto-Burgos, Xiaohong Zhuang, Liwen Jiang, Diane C. Bassham   +3 more
openaire   +3 more sources

Reconstitution reveals Ykt6 as the autophagosomal SNARE in autophagosome–vacuole fusion [PDF]

Journal of Cell Biology, 2018
Autophagy mediates the bulk degradation of cytoplasmic material, particularly during starvation. Upon the induction of autophagy, autophagosomes form a sealed membrane around cargo, fuse with a lytic compartment, and release the cargo for degradation.
Levent Bas, Daniel Papinski, Mariya Licheva, Raffaela Torggler, Sabrina Rohringer, Martina Schuschnig, Claudine Kraft   +6 more
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miR-4463 Regulates Hypoxia-Induced Autophagy and Apoptosis by Targeting ULK1 in Endothelial Cells

Frontiers in Bioscience-Landmark, 2022
Background: Our previous study revealed aberrant miR-4463 expression in the vascular tissues of patients with arteriosclerosis obliterans of the lower extremities (ASO), but the role of miR-4463 was largely ambiguous.
Xuemei He, Fei Wu, Yang Zhou, Jian Wu, Yang Long, Xiangyu Zhou   +5 more
doaj   +1 more source

CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages

Frontiers in Cellular and Infection Microbiology, 2022
Cystic fibrosis (CF) human and mouse macrophages are defective in their ability to clear bacteria such as Burkholderia cenocepacia. The autophagy process in CF (F508del) macrophages is halted, and the underlying mechanism remains unclear.
Asmaa Badr, Asmaa Badr, Mostafa Eltobgy, Kathrin Krause, Kathrin Krause, Kaitlin Hamilton, Shady Estfanous, Shady Estfanous, Kylene P. Daily, Arwa Abu Khweek, Arwa Abu Khweek, Ahmad Hegazi, Midhun N. K. Anne, Cierra Carafice, Frank Robledo-Avila, Youssra Saqr, Xiaoli Zhang, Tracey L. Bonfield, Mikhail A. Gavrilin, Santiago Partida-Sanchez, Stephanie Seveau, Estelle Cormet-Boyaka, Amal O. Amer   +22 more
doaj   +1 more source

Maturing Autophagosomes are Transported Towards the Cell Periphery

, 2021
Autophagosome maturation comprises fusion with lysosomes and acidification. It is a critical step in the degradation of cytosolic protein aggregates that characterize many neurodegenerative diseases. In order to better understand this process, we studied
Szegö, Eva M., Cozma, Diana, Hilverling, Anna, Saridaki, Theodora, Falkenburger, Bjoern, Dinter, Elisabeth   +5 more
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Recent Advances in Cellular Signaling Interplay between Redox Metabolism and Autophagy Modulation in Cancer: An Overview of Molecular Mechanisms and Therapeutic Interventions

Antioxidants, 2023
Autophagy is a fundamental homeostatic process in which certain cellular components are ingested by double-membrane autophagosomes and then degraded to create energy or to maintain cellular homeostasis and survival.
Md. Ataur Rahman, Kazi Rejvee Ahmed, Farzana Haque, Moon Nyeo Park, Bonglee Kim   +4 more
doaj   +1 more source

RGDV exploits autophagosomes to overcome insect transmission barriers.

, 2022
(A) Immunogold labeling of Pns11 in virus-containing autophagosomes. (B) At 6 days padp, insect intestines were immunolabeled with ATG8-rhodamine (red) and Pns11-FITC (green), and then examined by immunofluorescence microscopy.
Huan Liu (281351), Dongsheng Jia (521906), Taiyun Wei (123590), Aiming Wang (94532), Qifu Liang (10213964), Guangjun Li (10213958), Qian Chen (18883), Xiaofeng Zhang (172446)   +7 more
core   +1 more source

Herpesvirus and Autophagy: “All Right, Everybody Be Cool, This Is a Robbery!”

Viruses, 2017
Autophagy is an essential vacuolar process of the cell, leading to lysosomal degradation and recycling of proteins and organelles, which is extremely important in maintaining homeostasis.
Marion Lussignol, Audrey Esclatine
doaj   +1 more source

ROOT HAIR DEFECTIVE3 Is a Receptor for Selective Autophagy of the Endoplasmic Reticulum in Arabidopsis

Frontiers in Plant Science, 2022
ROOT HAIR DEFECTIVE3 (RHD3) is a plant member of atlastin GTPases, which belong to an evolutionally conserved family of proteins that mediate the homotypic fusion of the endoplasmic reticulum (ER).
Jiaqi Sun, Weina Wang, Huanquan Zheng
doaj   +1 more source