The EmERgence of Autophagosomes [PDF]
Developmental Cell, 2009 Autophagosomes are large double-membrane vesicles that enclose cytoplasmic components targeting them for degradation. Two recent reports reveal that phagophores, the autophagosome precursors, are surrounded by and connected to rough endoplasmic reticulum (ER) membranes.
Reggiori, Fulvio, Tooze, Sharon A
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Microtubules Facilitate Autophagosome Formation and Fusion of Autophagosomes with Endosomes [PDF]
Traffic, 2005 Nutrient deprivation of eukaryotic cells provokes a variety of stress responses, including autophagy. Autophagy is carried out by autophagosomes which sequester cytosolic components and organelles for degradation after fusion with protease‐containing endosomes.
Köchl, Robert +3 more
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The Intriguing Life of Autophagosomes [PDF]
International Journal of Molecular Sciences, 2012 Autophagosomes are double-membrane vesicles characteristic of macroautophagy, a degradative pathway for cytoplasmic material and organelles terminating in the lysosomal or vacuole compartment for mammals and yeast, respectively. This highly dynamic, multi-step process requires significant membrane reorganization events at different stages of the ...
Mijaljica, Dalibor +2 more
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Comprehensive proteomic analysis of autophagosomes derived from Leishmania-infected macrophages.
PLoS ONE, 2023 Recently, autophagy has been implicated as a host defense mechanism against intracellular pathogens. On the other hand, certain intracellular pathogens such as Leishmania can manipulate the host's autophagy to promote their survival.
Devki Nandan +5 more
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eLife, 2022 Autophagosomes are double-membrane intracellular vesicles that degrade protein aggregates, intracellular organelles, and other cellular components.
Omar Peña-Ramos +6 more
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HCV-induced autophagosomes are generated via homotypic fusion of phagophores that mediate HCV RNA replication. [PDF]
PLoS Pathogens, 2017 Hepatitis C virus (HCV) induces autophagy to promote its replication, including its RNA replication, which can take place on double-membrane vesicles known as autophagosomes.
Linya Wang +4 more
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Acetylated microtubules are required for fusion of autophagosomes with lysosomes [PDF]
BMC Cell Biology, 2010 Background Autophagy is a dynamic process during which isolation membranes package substrates to form autophagosomes that are fused with lysosomes to form autolysosomes for degradation.
Liu Leyuan +3 more
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Syntaxin 17 recruitment to mature autophagosomes is temporally regulated by PI4P accumulation
eLifeDuring macroautophagy, cytoplasmic constituents are engulfed by autophagosomes. Lysosomes fuse with closed autophagosomes but not with unclosed intermediate structures. This is achieved in part by the late recruitment of the autophagosomal SNARE syntaxin
Saori Shinoda +7 more
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LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes [PDF]
Biology Open, 2016 Autophagy is an evolutionarily conserved process used for removing surplus and damaged proteins and organelles from the cytoplasm. The unwanted material is incorporated into autophagosomes that eventually fuse with lysosomes, leading to the degradation ...
Virginie Hubert +5 more
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dnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degeneration. [PDF]
PLoS ONE, 2013 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. We previously showed that the expression of dynactin 1, an axon motor protein regulating retrograde transport, is markedly ...
Kensuke Ikenaka +11 more
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