Results 11 to 20 of about 138,875 (103)

Expression of small heat shock protein family and autophagy related proteins in the hippocampus of db/db mice with spontaneous type 2 diabetes [PDF]

Jichu yixue yu linchuang, 2020
Objective To study the changes of small heat shock proteins (sHSPs) and autophagy-related proteins in hippocampus of spontaneous type 2 diabetic db/db mice. Methods The db/m mice were used as control group, while diabetic db/db mice were used as model
LI Jin-feng, LI Xiao-cheng, YIN Xiao-hong, MA Wei-guo, LI Ya
doaj  

Astaxanthin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy via the ROS/MAPK Pathway in Mice

Marine Drugs, 2015
Background: Hepatic ischemia reperfusion (IR) is an important issue in complex liver resection and liver transplantation. The aim of the present study was to determine the protective effect of astaxanthin (ASX), an antioxidant, on hepatic IR injury via ...
Jingjing Li, Fan Wang, Yujing Xia, Weiqi Dai, Kan Chen, Sainan Li, Tong Liu, Yuanyuan Zheng, Jianrong Wang, Wenxia Lu, Yuqing Zhou, Qin Yin, Jie Lu, Yingqun Zhou, Chuanyong Guo   +14 more
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Deficiency of GABARAP but Not Its Paralogs Causes Enhanced EGF-Induced EGFR Degradation

Cells, 2020
The γ-aminobutyric acid type A receptor-associated protein (GABARAP) and its close paralogs GABARAPL1 and GABARAPL2 constitute a subfamily of the autophagy-related 8 (Atg8) protein family.
Jochen Dobner, Indra M. Simons, Kerstin Rufinatscha, Sebastian Hänsch, Melanie Schwarten, Oliver H. Weiergräber, Iman Abdollahzadeh, Thomas Gensch, Johannes G. Bode, Silke Hoffmann, Dieter Willbold   +10 more
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FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer

Cell Death and Disease, 2023
Metastatic colorectal cancer (mCRC) is a major cause of cancer-related mortality due to the absence of effective therapeutics. Thus, it is urgent to discover new drugs for mCRC.
Mengmeng Wang, Zhoudong Zhang, Mengxi Chen, Yixin Lv, Sheng Tian, Fanyi Meng, Yawen Zhang, Xuqin Guo, Yinshuang Chen, Man Yang, Jiawei Li, Tian Qiu, Fang Xu, Zhi Li, Qi Zhang, Jie Yang, Jing Sun, Hongjian Zhang, Haiyang Zhang, Huanqiu Li, Weipeng Wang   +20 more
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Toxoplasma TgAtg8-TgAtg3 Interaction Primarily Contributes to Apicoplast Inheritance and Parasite Growth in Tachyzoite

Microbiology Spectrum, 2022
The apicoplast, which harbors key pathways involved in biosynthesis of vital metabolites, is a unique and essential nonphotosynthetic plastid organelle in apicomplexan parasites.
Linyan Cheng, Yuan Tian, Yan Wang, Tingting Wang, Yinning Yao, Helin Yu, Xiaozi Zheng, Mimi Wu, Wei Zhao, Qianqian Hua, Xin Hu, Feng Tan   +11 more
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The Human Bcl-2 Family Member Bcl-rambo Localizes to Mitochondria and Induces Apoptosis and Morphological Aberrations in Drosophila. [PDF]

PLoS ONE, 2016
Bcl-2 family proteins play a central role in regulating apoptosis. We previously reported that human Bcl-rambo, also termed BCL2L13, localized to mitochondria and induced apoptosis when overexpressed in human embryonic kidney 293T cells.
Mako Nakazawa, Hisanori Matsubara, Yuka Matsushita, Megumi Watanabe, Nicole Vo, Hideki Yoshida, Masamitsu Yamaguchi, Takao Kataoka   +7 more
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Satellite III (1q12) Copy Number Variation in Cultured Human Skin Fibroblasts from Schizophrenic Patients and Healthy Controls

Frontiers in Bioscience-Landmark, 2023
Background: The chromosome 1q12 region harbors the genome’s largest pericentromeric heterochromatin domain that includes tandemly repeated satellite III DNA [SatIII (1)].
Elizaveta S. Ershova, Ekaterina A. Savinova, Larisa V. Kameneva, Lev N. Porokhovnik, Roman V. Veiko, Tatiana A. Salimova, Vera L. Izhevskaya, Sergei I. Kutsev, Natalia N.Veiko, Svetlana V. Kostyuk   +9 more
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The Roles of Ubiquitin-Binding Protein Shuttles in the Degradative Fate of Ubiquitinated Proteins in the Ubiquitin-Proteasome System and Autophagy

Cells, 2019
The ubiquitin-proteasome system (UPS) and autophagy are the two major intracellular protein quality control (PQC) pathways that are responsible for cellular proteostasis (homeostasis of the proteome) by ensuring the timely degradation of misfolded ...
Katarzyna Zientara-Rytter, Suresh Subramani   +1 more
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Cloning and Expression Analysis of ATG8 (Autophagy-Related 8) Gene Family in Solanaceae

Plants
The autophagy-related gene family ATG8 (Autophagy-related 8) plays an important role in plant growth, development, and stress response. In this study, 15 ATG8 gene family sequences were amplified from Solanaceae, namely tobacco, tomato, and pepper, using
Yahan Chen, Yunshuang Lu, Shibo Dong, Chengde Yang, Shunyi Yang   +4 more
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ATG9A-dependent, LC3-independent autophagy curbs the immune system to protect against disease

Autophagy Reports
Selective autophagy is generally believed to require the conjugation of microtubule associated protein 1 light chain 3 (LC3) proteins (or other autophagy-related 8 [ATG8] family members) on the inner phagophore leaflet to enable the recruitment of cargo ...
Dario Priem, Mathieu JM Bertrand
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