Results 21 to 30 of about 138,875 (103)

Mechanisms and roles of membrane-anchored ATG8s

Frontiers in Cell and Developmental Biology
Autophagy-related protein 8 (ATG8) family proteins, including LC3 and GABARAP subfamilies, are pivotal in canonical autophagy, driving autophagosome formation, cargo selection, and lysosomal fusion.
Soo-Kyeong Lee, Sang-Won Park, Deok-Jin Jang, Jin-A. Lee   +3 more
doaj   +1 more source

Grape Seed Proanthocyanidins Alleviate Glucolipotoxicity-induced Ferroptosis in MIN6 Cells by Activating Nrf2/HO-1-Mediated Autophagy

Shipin gongye ke-ji
Objective: This study aimed to investigate whether grape seed procyanidin extract (GSPE) can enhance autophagy through the nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase-1 (HO-1) signaling pathway and thereby inhibit glucolipotoxicity ...
Tingting LI, Ruirui YANG, Hao WANG, Heng LU, Yusong DING   +4 more
doaj   +1 more source

3,4-methylenedioxymethamphetamine induces reactive oxygen species-mediated autophagy and thioredoxin-interactive protein/nucleotide-binding domain, leucine-rich containing family, pyrin domain-containing-3 inflammasome activation in dental pulp stem cells

Journal of Dental Sciences
Background/purpose: 3,4-methylenedioxymethamphetamine (MDMA) is a synthetic substituted amphetamine. Research primarily focuses on its neurotoxicity and psychological effects, while studies examining its impact on mesenchymal stem cells (MSCs) and dental
Shih-Yu Lee, Shang-Wen Chiu, I-Hsun Li, Wei-Cheng Tsai, Chung-Hsing Li   +4 more
doaj   +1 more source

Antiviral effects and mechanisms of chlorogenic acid against SGIV and NNV infection

Aquaculture Reports
Singapore grouper iridovirus (SGIV) and nervous necrosis virus (NNV) are major viral pathogens in grouper aquaculture, for which validated and practically applicable prophylactic or therapeutic strategies remain limited.
Jinpeng Chen, Hannan Gong, Lifang Cao, Qiwei Qin, Min Yang, Shina Wei   +5 more
doaj   +1 more source

SLC34A2 promotes cell proliferation by activating STX17‐mediated autophagy in esophageal squamous cell carcinoma

Thoracic Cancer
Background Solute carrier family 34 member 2 (SLC34A2) has been implicated in the development of various malignancies. However, the clinical significance and underlying molecular mechanisms of SLC34A2 in esophageal squamous cell carcinoma (ESCC) remain ...
Yi Xu, Shiyu Duan, Wen Ye, Zhousan Zheng, Jiaxing Zhang, Ying Gao, Sheng Ye   +6 more
doaj   +1 more source

Zoledronic Acid Inhibits Lipopolysaccharide‐Induced Osteoclastogenesis by Suppressing Macrophage NLRP3‐Mediated Autophagy Pathway

Immunity, Inflammation and Disease
Introduction Inflammatory factors leading to bone loss significantly increase the risk of tooth loosening or implantation failure. Zoledronic acid (ZOL) is a widely used medication for effectively inhibiting excessive bone destruction, but its effect on ...
Yuting Cheng, Guanjuan Liu, Xiaolin Huang, Yue Xiong, Na Song, Zheqing An, Wei Hong, Chidchanok Leethanakul, Bancha Samruajbenjakun, Jian Liao   +9 more
doaj   +1 more source

Small heat shock protein B8: from cell functions to its involvement in diseases and potential therapeutic applications

Neural Regeneration Research
Heat shock protein family B (small) member 8 (HSPB8) is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock proteins. HSPB8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in ...
Marta Chierichetti, Riccardo Cristofani, Valeria Crippa, Veronica Ferrari, Marta Cozzi, Elena Casarotto, Paola Pramaggiore, Laura Cornaggia, Guglielmo Patelli, Ali Mohamed, Margherita Piccolella, Mariarita Galbiati, Paola Rusmini, Barbara Tedesco, Angelo Poletti   +14 more
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Ginsenoside Rd protects against acute liver injury by regulating the autophagy NLRP3 inflammasome pathway

Scientific Reports
Ginsenoside Rd (Rd) is a bioactive compound predominantly found in Panax ginseng C.A. Meyer and Panax notoginseng (Burkill) F.H. Chen ex C.H. Chow, both species belonging to genus Panax in the Araliaceae family.
Xiaomei Zhong, Yibin Sun, Yanxiang Lin, Shan Deng, Huan Wang, Xian Zhou, Jinjian Lu, Yanfang Zheng, Ruoyin Luo, Mingqing Huang, Jianyuan Song   +10 more
doaj   +1 more source

Deoxyshikonin inhibits growth and induces apoptosis of hypertrophic scar-derived fibroblasts by downregulating FBXO expression through autophagy

Scientific Reports
Hypertrophic scar (HS) is a fibro-proliferative disorder of cutaneous wound healing, which seriously impacts the patient’s quality of life. Deoxyshikonin (DSK) as a natural shikonin derivative possesses various pharmacological effects, however, whether ...
Meirong Yan, Renzhang Liang, Lifeng Guan, Qiyun Luo, Xiaoyan Zhang, Hua Tian, Xuejun Wu   +6 more
doaj   +1 more source

Microbial metabolite trimethylamine-N-oxide facilitates colorectal inflammation-cancer transformation by blocking lysosomal degradation of Wnt signaling

Gut Microbes
Chronic inflammation is closely related to the occurrence and development of many tumors, including colorectal cancer (CRC), a typical inflammation-dependent cancer.
Kui Yang, Zhenni Liu, Huijun Wang, Zhengtao Xiao, Wei Zhao, Wenbin Gong   +5 more
doaj   +1 more source