Results 11 to 20 of about 449,405 (356)
Autophagy and autophagy-related proteins in cancer [PDF]
Molecular Cancer, 2020 Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related (ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression and inhibition remains controversial, in which the numerous ATG proteins ...
Xiaohua Li, Shi-kun He, Binyun Ma
semanticscholar +5 more sources
Autophagy genes in biology and disease
Nature reviews genetics, 2023 Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic membrane dynamics regulated by autophagy-related proteins and other molecules, some ...
Hayashi Yamamoto +2 more
semanticscholar +1 more source
The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy
Autophagy Reports, 2023 Mitochondria are the center for energy production, cell fate determination and synthesis of essential biomolecules in cells. Hence, mitochondrial quality control mechanisms are essential for cellular health.
Anne Kristin McLaren Berge +3 more
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The role of autophagy in bone metabolism and clinical significance
Autophagy, 2023 The skeletal system is the basis of the vertebral body composition, which affords stabilization sites for muscle attachment, protects vital organs, stores mineral ions, supplies places to the hematopoietic system, and participates in complex endocrine ...
Jing Wang +10 more
semanticscholar +1 more source
Cell Death and Disease, 2022 Cancer genomics and cancer mutation databases have made an available wealth of information about missense mutations found in cancer patient samples. Contextualizing by means of annotation and predicting the effect of amino acid change help identify which
Matteo Tiberti +6 more
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Cells, 2022 Cancer is one of the leading causes of death worldwide, thus the search for new cancer therapies is of utmost importance. Ursolic acid is a naturally occurring pentacyclic triterpene with a wide range of pharmacological activities including anti ...
Ditte L. Fogde +9 more
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Autophagy and neurodegeneration [PDF]
Free Radical Biology and Medicine, 2012 Most neurodegenerative diseases that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a powerful process for removing such proteins. In this Review, we consider how certain neurodegenerative diseases may be associated with impaired autophagy and how this may affect pathology.
Thomas Ricketts +3 more
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Cells, 2012 Autophagy is a housekeeping survival mechanism with a protective function against stress conditions. However, when stress severity or duration increases, it may promote cell death. Paradoxically, autophagy favors cancer development, since cancer cells could enhance their proliferation potential (thus becoming able to resist anticancer therapy) thanks ...
Luis Miguel Guamán Ortiz +3 more
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Autophagy in Trypanosomatids [PDF]
Cells, 2012 Autophagy is a ubiquitous eukaryotic process that also occurs in trypanosomatid parasites, protist organisms belonging to the supergroup Excavata, distinct from the supergroup Opistokontha that includes mammals and fungi. Half of the known yeast and mammalian AuTophaGy (ATG) proteins were detected in trypanosomatids, although with low sequence ...
Brennand, A. +2 more
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The Role of Autophagy in the Female Reproduction System: For Beginners to Experts in This Field
Biology, 2023 Autophagy is a fundamental process involved in regulating cellular homeostasis. Autophagy has been classically discovered as a cellular process that degrades cytoplasmic components non-selectively to produce energy.
Akitoshi Nakashima +12 more
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