Results 11 to 20 of about 687,627 (397)
Autophagy and autophagy-related proteins in cancer [PDF]
Molecular Cancer, 2020 Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related (ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression and inhibition remains controversial, in which the numerous ATG proteins ...
Xiaohua Li, Shi-kun He, Binyun Ma
semanticscholar +4 more sources
Cancer Science, 2021 AbstractWhile starvation‐induced autophagy is thought to randomly degrade cellular components, under certain circumstances autophagy selectively recognizes, sequesters, and degrades specific targets via autophagosomes. This process is called selective autophagy, and it contributes to cellular homeostasis by degrading specific soluble proteins ...
Mohammad Omar Faruk +2 more
openaire +2 more sources
Copper metabolism in cell death and autophagy
Autophagy, 2023 Copper is an essential trace element in biological systems, maintaining the activity of enzymes and the function of transcription factors. However, at high concentrations, copper ions show increased toxicity by inducing regulated cell death, such as ...
Qian Xue +5 more
semanticscholar +1 more source
Unraveling membrane properties at the organelle-level with LipidDyn
Computational and Structural Biotechnology Journal, 2022 Cellular membranes are formed from different lipids in various amounts and proportions depending on the subcellular localization. The lipid composition of membranes is sensitive to changes in the cellular environment, and its alterations are linked to ...
Simone Scrima +11 more
doaj +1 more source
Current Biology, 2019 In 1955, the biologist and Nobel Prize laureate Christian de Duve discovered that cells possess specialized organelles filled with hydrolytic enzymes and he called these organelles lysosomes. At the same time, electron microscopy studies by Novikoff and colleagues showed that intracellular dense bodies, which later turned out to be lysosomes, contain ...
openaire +4 more sources
Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot
Biology, 2020 Autophagy is a highly conserved degradation mechanism that is essential for maintaining cellular homeostasis. In human disease, autophagy pathways are frequently deregulated and there is immense interest in targeting autophagy for therapeutic approaches.
Magali Humbert +17 more
doaj +1 more source
The Role of Autophagy in the Female Reproduction System: For Beginners to Experts in This Field
Biology, 2023 Autophagy is a fundamental process involved in regulating cellular homeostasis. Autophagy has been classically discovered as a cellular process that degrades cytoplasmic components non-selectively to produce energy.
Akitoshi Nakashima +12 more
doaj +1 more source
Cells, 2022 The recent discovery demonstrating that the leakage of cathepsin B from mitotic lysosomes assists mitotic chromosome segregation indicates that lysosomal membrane integrity can be spatiotemporally regulated.
Jonathan Stahl-Meyer +4 more
doaj +1 more source
The role of autophagy in bone metabolism and clinical significance
Autophagy, 2023 The skeletal system is the basis of the vertebral body composition, which affords stabilization sites for muscle attachment, protects vital organs, stores mineral ions, supplies places to the hematopoietic system, and participates in complex endocrine ...
Jing Wang +10 more
semanticscholar +1 more source