Results 251 to 260 of about 449,405 (356)

Extracellular LCN2 Binding to 24p3R in Astrocytes Impedes α‐Synuclein Endocytosis in Parkinson's Disease

Advanced Science, EarlyView.
24p3R is an astrocytic receptor for α‐Syn uptake. When LCN2 is secreted from astrocytes, it binds to its receptor 24p3R in astrocytes and this binding impedes the α‐Syn PFF binding to 24p3R. This in turn inhibits 24p3R‐mediated α‐Syn PFF uptake and reduces the clearance of extracellular α‐Syn by astrocytes, which contributes to α‐Syn spread and ...
Ying‐Ying Jiao, Tian Tian, Zhu Zhu, Lei Cao, Yang Liu, Rui‐An Wang, Zhi‐Yong Zhou, Cong Wang, Ke‐Zhong Zhang, Xiao Lu, Wen‐Wei Yun, Ying‐Mei Lu, Gang Hu, Ren‐Hong Du, Ming Lu   +14 more
wiley   +1 more source

The Rod Steers the Globe in ATG9A-Mediated Lipid Transport

Autophagy Reports
Alexander R. van Vliet, Sharon A. Tooze
doaj   +1 more source

HMGB1 regulates autophagy via TLR4/NF-κB signaling pathway in myocardial injury induced by coronary microembolization. [PDF]

Eur J Med Res
Yang T, Wu X, Wang X.
europepmc   +1 more source

TFEB Links Autophagy to Lysosomal Biogenesis

Science, 2011
C. Settembre, Chiara Di Malta, V. A. Polito, Moises Garcia Arencibia, Francesco Vetrini, Serkan Erdin, S. Erdin, Tuong Huynh, D. Medina, P. Colella, Marco Sardiello, D. Rubinsztein, A. Ballabio   +12 more
semanticscholar   +1 more source

Glycolytic Enzyme HK2 Phosphorylates nSMase1 to Promote Astrocytic Exosomes Biogenesis Contributing to Acute Ischemic Stroke Injury

Advanced Science, EarlyView.
This study reveals that the glycolytic enzyme HK2 mediates hypoxia‐induced astrocytic exosome biogenesis by directly phosphorylating nSMase1. These astrocytic exosomes impair brain endothelial tight junctions. Astrocyte‐specific knockdown of HK2 reduces exosome release and alleviates brain injury after MCAO.
Chen Chen, YuWei Zhou, LongXiang Sheng, FangYing Mai, YuXuan Ding, ShiRan Hong, JiaXin Wu, JiaKai Pi, GuangMei Yan, YiJun Huang, JingJing Duan, Xuefeng Hua, Wei Yin   +12 more
wiley   +1 more source

Single‐Cell Transcriptome Analysis Reveals That Hmga2 Regulates Neuroinflammation and Retinal Function by Modulating Müller Cell Autophagy Through PI3K/AKT Signaling Following MCAO‐Induced Retinal Ischemia

Advanced Science, EarlyView.
Employing snRNA‐seq post‐MCAO‐induced retinal ischemia (RI), this study revealed a novel Hmga2‐high Müller cell subpopulation. Hmga2 knockout alleviated neuroinflammation and RI symptoms, potentially by binding PI3K and regulating Müller cell autophagy.
Weihao Lv, Juzheng Yuan, Zhe Ruan, Ya‐nan Dou, Hongchen Zhang, Xiaowei Fei, Leiying Chen, Zehan Zhang, Kai Yang, Xiuquan Wu, Zhou Fei, Fei Fei   +11 more
wiley   +1 more source

Autophagy inhibition improves the efficacy of anlotinib and PD-1 inhibitors in the treatment of NSCLC. [PDF]

J Immunother Cancer
Tang H, You T, Ge H, Bai C, Wang Y, Sun Z, Han Q, Zhao RC.   +7 more
europepmc   +1 more source

Atg17 Functions in Cooperation with Atg1 and Atg13 in Yeast Autophagy [PDF]

, 2005
Yukiko Kabeya, Yoshiaki Kamada, Misuzu Baba, Hirosato Takikawa, Mitsuru Sasaki, Yoshinori Ohsumi   +5 more
openalex   +1 more source

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

EMBO Journal, 2008
G. Twig, Alvaro A. Elorza, A. Molina, Hibo Mohamed, J. Wikstrom, G. Walzer, L. Stiles, S. E. Haigh, Steve Katz, G. Las, J. Alroy, Min Wu, B. Py, Junying Yuan, J. Deeney, B. Corkey, O. Shirihai   +16 more
semanticscholar   +1 more source

Capsaicin Alleviates Autophagy‐Lysosomal Dysfunction via PPARA‐Mediated V‐ATPase Subunit ATP6V0E1 Signaling in 3xTg‐AD Mice

Advanced Science, EarlyView.
Capsaicin enhances lipid metabolism, reduces lipid deposition, and alleviates AD‐related pathologies. Capsaicin activates PPARA, promoting the expression of PPAR signaling pathway‐related genes and accelerating lipid metabolism. Capsaicin upregulates ATP6V0E1‐V‐ATPase‐mediated lysosomal acidification, enhancing lipid droplet clearance. PPARA is the key
Haitao Yu, Jia Chen, Fangzhou Wang, Dongdong Jia, Shuguang Bi, Yuming Mao, Yu‐qi Zhang, Tian‐long Gao, Liu Yang, Jia‐xu Du, Zi‐han Zhou, Xi‐Chen Zhu, Gao‐shang Chai   +12 more
wiley   +1 more source