Results 21 to 30 of about 449,405 (356)
Autophagy and Tumorigenesis [PDF]
Seminars in Immunopathology, 2010 Autophagy, a catabolic process involved in the sequestration and lysosomal degradation of cytoplasmic contents, is crucial for cellular homeostasis. The current literature supports that autophagy plays diverse roles in the development, maintenance, and progression of tumors.
Roy, Srirupa, Debnath, Jayanta
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Unraveling membrane properties at the organelle-level with LipidDyn
Computational and Structural Biotechnology Journal, 2022 Cellular membranes are formed from different lipids in various amounts and proportions depending on the subcellular localization. The lipid composition of membranes is sensitive to changes in the cellular environment, and its alterations are linked to ...
Simone Scrima +11 more
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Cells, 2022 The recent discovery demonstrating that the leakage of cathepsin B from mitotic lysosomes assists mitotic chromosome segregation indicates that lysosomal membrane integrity can be spatiotemporally regulated.
Jonathan Stahl-Meyer +4 more
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Autophagy-Independent Functions of the Autophagy Machinery [PDF]
Cell, 2019 Macroautophagy (herein referred to as autophagy) is an evolutionary ancient mechanism that culminates with the lysosomal degradation of superfluous or potentially dangerous cytosolic entities. Over the past 2 decades, the molecular mechanisms underlying several variants of autophagy have been characterized in detail. Accumulating evidence suggests that
Galluzzi, Lorenzo, Green, Douglas R.
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Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot
Biology, 2020 Autophagy is a highly conserved degradation mechanism that is essential for maintaining cellular homeostasis. In human disease, autophagy pathways are frequently deregulated and there is immense interest in targeting autophagy for therapeutic approaches.
Magali Humbert +17 more
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Autophagy and inflammation [PDF]
Clinical and Translational Medicine, 2017 AbstractAutophagy is a homeostatic mechanism involved in the disposal of damaged organelles, denatured proteins as well as invaded pathogens through a lysosomal degradation pathway. Recently, increasing evidences have demonstrated its role in both innate and adaptive immunity, and thereby influence the pathogenesis of inflammatory diseases.
Xiangdong Wang +2 more
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Annals of the New York Academy of Sciences, 2006 Abstract: Autophagy is a major intracellular pathway for the degradation and recycling of long‐lived proteins and cytoplasmic organelles. Like apoptotic programmed cell death, autophagy is an essential part of growth regulation and maintenance of homeostasis in multicellular organisms.
Thoms, Sven, Schwab, Manfred
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Cell, 2011 Genetic inhibition of autophagy induces degenerative changes in mammalian tissues that resemble those associated with aging, and normal and pathological aging are often associated with a reduced autophagic potential. Pharmacological or genetic manipulations that increase life span in model organisms often stimulate autophagy, and its inhibition ...
Guido Kroemer +4 more
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Mitophagy and Neurodegeneration: Between the Knowns and the Unknowns
Frontiers in Cell and Developmental Biology, 2022 Macroautophagy (henceforth autophagy) an evolutionary conserved intracellular pathway, involves lysosomal degradation of damaged and superfluous cytosolic contents to maintain cellular homeostasis.
Cuckoo Teresa Jetto +3 more
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Autophagy Flux Correlates with Upregulation of AKT-1 in RAS Mutated Colon Cancer Cells [PDF]
Middle East Journal of Cancer, 2021 Background: The AKT/PKB (protein kinase B) kinase is the main regulator of autophagy in mammalian cells, which consists of three isoforms, including AKT-1, AKT-2, and AKT-3.
Hamid Behrouj +3 more
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