Results 21 to 30 of about 687,627 (397)
Mitophagy and Neurodegeneration: Between the Knowns and the Unknowns
Frontiers in Cell and Developmental Biology, 2022 Macroautophagy (henceforth autophagy) an evolutionary conserved intracellular pathway, involves lysosomal degradation of damaged and superfluous cytosolic contents to maintain cellular homeostasis.
Cuckoo Teresa Jetto +3 more
doaj +1 more source
Autophagy in major human diseases
EMBO Journal, 2021 Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models.
D. Klionsky +58 more
semanticscholar +1 more source
Current Opinion in Cell Biology, 2015 Autophagy, once viewed exclusively as a cytoplasmic auto-digestive process, has its less intuitive but biologically distinct non-degradative roles. One manifestation of these functions of the autophagic machinery is the process termed secretory autophagy. Secretory autophagy facilitates unconventional secretion of the cytosolic cargo such as leaderless
Marisa, Ponpuak +5 more
openaire +2 more sources
Autophagy Flux Correlates with Upregulation of AKT-1 in RAS Mutated Colon Cancer Cells [PDF]
Middle East Journal of Cancer, 2021 Background: The AKT/PKB (protein kinase B) kinase is the main regulator of autophagy in mammalian cells, which consists of three isoforms, including AKT-1, AKT-2, and AKT-3.
Hamid Behrouj +3 more
doaj +1 more source
ERMP1 Facilitates The Malignant Characteristics of Colorectal Cancer Cells through Modulating PI3K/AKT/β-Catenin Pathway and Localization of GRP78 [PDF]
Cell Journal, 2023 Objective: Endoplasmic reticulum-metallopeptidase 1 (ERMP1) is involved in cellular response to oxidative stress.However, its functional role in proliferation and progression of cancer cells remains unknown.
Nasim Rahmani-Kukia +2 more
doaj +1 more source
Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies [PDF]
, 2016 OBJECTIVES: Autophagy may represent a functional processing event that creates a substrate for autoreactivity. In particular, autophagy may play a role in the pathogenesis of RA, since autophagy is a key cellular event involved in the generation of ...
Alessandra Nerviani +14 more
core +1 more source
The selectivity and specificity of autophagy in drosophila [PDF]
, 2012 Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a ...
Chou +27 more
core +2 more sources
Autophagy and Autophagy-Related Diseases: A Review [PDF]
International Journal of Molecular Sciences, 2020 Autophagy refers to the process involving the decomposition of intracellular components via lysosomes. Autophagy plays an important role in maintaining and regulating cell homeostasis by degrading intracellular components and providing degradation products to cells.
Tadashi Ichimiya +8 more
openaire +2 more sources
Experimental Control and Characterization of Autophagy in Drosophila [PDF]
, 2008 Insects such as the fruit fly Drosophila melanogaster, which fundamentally reorganize their body plan during metamorphosis, make extensive use of autophagy for their normal development and physiology.
A.D. Velentzas +18 more
core +1 more source
Autophagy and autophagy signaling in Epilepsy: possible role of autophagy activator
Molecular Medicine, 2023 AbstractAutophagy is an explicit cellular process to deliver dissimilar cytoplasmic misfolded proteins, lipids and damaged organelles to the lysosomes for degradation and elimination. The mechanistic target of rapamycin (mTOR) is the main negative regulator of autophagy.
Naif H. Ali +7 more
openaire +3 more sources