Results 61 to 70 of about 449,405 (356)
Annexins: players of single cell wound healing and regeneration
Communicative & Integrative Biology, 2019 Cell life is defined by a thin 4 nm plasma membrane, which separates the interior of a cell from its environment. Thus, disruption of the plasma membrane poses a critical risk to cells, which requires immediate repair to avoid uncontrolled osmotic lysis ...
Swantje Christin Häger +1 more
doaj +1 more source
Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
Nature Communications, 2020 Lysosomes are intracellular organelles containing degradative enzymes, and leakage of lysosomal contents into the cell is thought to trigger cell death.
Saara Hämälistö +11 more
doaj +1 more source
Zinc Finger Transcription Factor MZF1—A Specific Regulator of Cancer Invasion
Cells, 2020 Over 90% of cancer deaths are due to cancer cells metastasizing into other organs. Invasion is a prerequisite for metastasis formation. Thus, inhibition of invasion can be an efficient way to prevent disease progression in these patients.
Ditte Marie Brix +2 more
doaj +1 more source
Cell Death Discovery, 2021 The sirtuin (SIRT) protein family has been of major research interest over the last decades because of their involvement in aging, cancer, and cell death.
Marius W. Baeken +5 more
doaj +1 more source
Nature Medicine, 2010 Susceptibility to Crohn's disease has been linked to polymorphisms in genes involved in two pathophysiological pathways: autophagy and the recognition of bacterial peptidoglycan by nucleotide oligomerization domain-2 (NOD2), an intracellular receptor.
Netea, M.G., Joosten, L.A.B.
openaire +3 more sources
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Bio-Protocol, 2018 Autophagy is a key player in the maintenance of cellular homeostasis in eukaryotes, and numerous diseases, including cancer and neurodegenerative disorders, are associated with alterations in autophagy.
Morten Luhr +2 more
doaj +1 more source
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Autophagy and autoimmunity [PDF]
Clinical Immunology, 2017 Autophagy is a highly conserved protein degradation pathway from yeasts to humans that is essential for removing protein aggregates and misfolded proteins in healthy cells. Recently, autophagy-related genes polymorphisms have been implicated in several autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis, psoriasis, and ...
Dennis J. Wu +2 more
openaire +4 more sources
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source