Results 51 to 60 of about 75,578 (255)

The Role of Autophagy in Osteoarthritic Cartilage

Biomolecules, 2022
Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA.
Wei-Chun Kao, Jian-Chih Chen, Ping-Cheng Liu, Cheng-Chang Lu, Sung-Yen Lin, Shu-Chun Chuang, Shun-Cheng Wu, Ling-hua Chang, Mon-Juan Lee, Chung-Da Yang, Tien-Ching Lee, Ying-Chun Wang, Jhong-You Li, Chun-Wang Wei, Chung-Hwan Chen   +14 more
doaj   +1 more source

Autophagy related gene CEP55 is a potential biomarker for osteoarthritis

, 2023
Abstract Objective To screen the target autophagy related genes that may play an important role in the development of osteoarthritis. Methods We analyzed the differentially expressed genes between osteoarthritis samples and control samples in the online dataset GSE46750.
Qiang Li, Yong Hu
openaire   +1 more source

Cadmium-Induced Autophagy in Rat Kidney: An Early Biomarker of Subtoxic Exposure [PDF]

Toxicological Sciences, 2011
Environmental exposures to cadmium (Cd) are a major cause of human toxicity. The kidney is the most sensitive organ; however, the natures of injuries and of adaptive responses have not been adequately investigated, particularly in response to environmental relevant Cd concentrations.
Abderrahman, Chargui, Sami, Zekri, Gregory, Jacquillet, Isabelle, Rubera, Marius, Ilie, Amine, Belaid, Christophe, Duranton, Michel, Tauc, Paul, Hofman, Philippe, Poujeol, Michèle V, El May, Baharia, Mograbi   +11 more
openaire   +2 more sources

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Comprehensive machine learning and experimental verification reveal the mechanism of action of autophagy-related genes FIZ1 and FBXO21 in acute kidney injury [PDF]

PeerJ
Background Acute kidney injury (AKI) is a serious disease with a high incidence and easy induction. The search for innovative biomarkers and treatment methods is of great significance for improving the prognosis of patients.
Yunqi Bai, Lili Zhang, Bo Nie, Yixin Su, Jingwei Zhou   +4 more
doaj   +2 more sources

Regulation of autophagy by microRNAs in human breast cancer

Journal of Biomedical Science, 2021
Breast cancer is the most common solid cancer that affects female population globally. MicroRNAs (miRNAs) are short non-coding RNAs that can regulate post-transcriptional modification of multiple downstream genes.
Zhi Xiong Chong, Swee Keong Yeap, Wan Yong Ho   +2 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson’s Disease

Clinical and Translational Science, 2021
The current diagnosis of Parkinson’s disease (PD) mostly relies on clinical rating scales related to motor dysfunction. Given that clinical symptoms of PD appear after significant neuronal cell death in the brain, it is required to identify accessible ...
Juhee Kang, Jae Whan Kim, Hansol Heo, Jihyun Lee, Kwan Yong Park, Jung Han Yoon, Jaerak Chang   +6 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Exploring the mechanism of autophagy and inflammation in osteoarthritis through bioinformatics and experimental verification

Autoimmunity
Osteoarthritis (OA) is a chronic joint disorder characterized by cartilage degradation and accompanied by inflammatory processes. Inflammation and autophagy dysfunction have been associated with the pathogenesis of OA.
Shihu Kan, Songxiahe Zhao, Lei Chen, Zhongjiang Lan, Yanliang Jiao, Yibin Du   +5 more
doaj   +1 more source