Results 41 to 50 of about 75,578 (255)

The role of circular RNAs in gastric Cancer: Focusing on autophagy, EMT, and their crosstalk

Biochemistry and Biophysics Reports
Globally, gastric cancer (GC) is one of the leading causes of cancer-related mortality. GC is a major threat and concern in human societies because of the high degree of metastasis and the lack of primary diagnostic biomarkers.
Seyedeh Zahra Bakhti, Saeid Latifi-Navid, Anahita Dah Pahlevan, Latifeh Sarabi, Reza Safaralizadeh   +4 more
doaj   +1 more source

Identification and validation of P4HB as a novel autophagy-related biomarker in diabetic nephropathy

Frontiers in Genetics, 2022
Diabetic nephropathy (DN), a frequent microvascular complication of diabetes, has been recognized as a primary cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD). Previous studies found that autophagy of renal tubular epithelial cells plays an important role in DN pathogenesis.
Fang Bai, Fang Bai, Kuipeng Yu, Yanjiang Yang, Yimeng Zhang, Lin Ding, Xin An, Feng Feng, Nan Sun, Jiahui Fan, Lei Liu, Huimin Yang, Xiangdong Yang   +12 more
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Unveiling the Paradoxical Nature of Autophagy in Cancer Cell Fate

Cancer Control
Autophagy is an ancient conserved and catabolic process required to maintain cellular homeostasis through sequestration and lysosomal degradation of cytosolic dysfunctional contents.
Jannatul Shifa BSc, Tasbir Amin BSc, Md. Fakruddin PhD, Kazi Rahman PhD, S. M. Bakhtiar Ul Islam PhD   +4 more
doaj   +1 more source

Relevance of Autophagy and Mitophagy Dynamics and Markers in Neurodegenerative Diseases

Biomedicines, 2021
During the past few decades, considerable efforts have been made to discover and validate new molecular mechanisms and biomarkers of neurodegenerative diseases.
Carlotta Giorgi, Esmaa Bouhamida, Alberto Danese, Maurizio Previati, Paolo Pinton, Simone Patergnani   +5 more
doaj   +1 more source

Prognostic Impact of Autophagy and Immunity Related Biomarker for Uveal Melanoma [PDF]

, 2021
Abstract Background: Autophagy and immunity related genes serve crucial roles in carcinogenesis, but little is known about the prognostic impact for uveal melanoma (UM).Methods: Autophagy related and immunity related genes (AIRGs) expression data of 80 UM patients were obtained from the cancer genome atlas project (TCGA) database.
Huibin Du, Yan He, Wei Lu, Qi Wan
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The emerging roles of circular RNA-mediated autophagy in tumorigenesis and cancer progression

Cell Death Discovery, 2022
Circular RNA (circRNA) is characterized by a specific covalently closed ring structure. The back-splicing of precursor mRNA is the main way of circRNA generation, and various cis/trans-acting elements are involved in regulating the process.
Yuan Yuan, Xiaojing Zhang, Xinmin Fan, Yin Peng, Zhe Jin   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Identification of autophagy-related risk signatures for the prognosis, diagnosis, and targeted therapy in cervical cancer

Cancer Cell International, 2021
Background To rummage autophagy-related prognostic, diagnostic, and therapeutic biomarkers in cervical cancer (CC). Methods The RNA-sequence and clinical information were from the TCGA and GTEx databases.
Dan Meng, Hua Jin, Xing Zhang, Wenjing Yan, Qianqian Xia, Siyuan Shen, Shuqian Xie, Mengjing Cui, Bo Ding, Yun Gu, Shizhi Wang   +10 more
doaj   +1 more source