Results 21 to 30 of about 116,566 (305)
Cancer Medicine, 2023 Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy and is unresponsive to conventional therapeutic modalities due to its high heterogeneity, expounding the necessity, and priority of searching for effective biomarkers and drugs ...
Yonghao Chen +4 more
doaj +1 more source
Scientific Reports, 2023 Psoriasis vulgaris is the most common form of the four clinical types. However, early diagnosis of psoriasis vulgaris is difficult due to the lack of effective biomarkers.
Ailing Zou +4 more
doaj +1 more source
Identification and Analysis of Potential Autophagy-Related Biomarkers in Endometriosis by WGCNA [PDF]
Frontiers in Molecular Biosciences, 2021 Background: Endometriosis is a serious gynecological disorder characterized by debilitating pain, infertility and the establishment of innervated endometriosis lesions outside the uterus. Early detection and accurate diagnosis are pivotal in endometriosis.
Jing Wang +7 more
openaire +3 more sources
Journey to the Center of the Fetal Brain: Environmental Exposures and Autophagy
Frontiers in Cellular Neuroscience, 2018 Fetal brain development is known to be affected by adverse environmental exposures during pregnancy, including infection, inflammation, hypoxia, alcohol, starvation, and toxins.
Jun Lei +3 more
doaj +1 more source
New insights into autophagy in inflammatory subtypes of asthma
Frontiers in Immunology, 2023 Asthma is a heterogeneous airway disease characterized by airway inflammation and hyperresponsiveness. Autophagy is a self-degrading process that helps maintain cellular homeostasis.
Hongna Dong +6 more
doaj +1 more source
Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid. [PDF]
, 2016 BackgroundClinical diagnosis of parkinsonian syndromes like Parkinson's disease (PD), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) is hampered by overlapping symptomatology and lack of diagnostic biomarkers, and definitive ...
Boman, Andrea +8 more
core +1 more source
FRI0515 HSP90AA1, A CHAPERONE-MEDIATED AUTOPHAGY, IS A BIOMARKER ASSOCIATED WITH DEFECTIVE AUTOPHAGY IN OSTEOARTHRITIS [PDF]
Annals of the Rheumatic Diseases, 2019 Background In osteoarthritis (OA), defects in cellular homeostasis, such as autophagy, are evident and precede joint damage (1). We have shown that there is a defect in autophagy in OA human chondrocytes and cartilage (2). Indeed, pharmacological activation of autophagy protects against joint damage (3).
Irene Lorenzo +4 more
openaire +1 more source
Autophagy-related proteins: Potential diagnostic and prognostic biomarkers of aging-related diseases
Ageing Research Reviews, 2023 Autophagy plays a key role in cellular, tissue and organismal homeostasis and in the production of the energy load needed at critical times during development and in response to nutrient shortage. Autophagy is generally considered as a pro-survival mechanism, although its deregulation has been linked to non-apoptotic cell death.
Caterina, Miceli +3 more
openaire +2 more sources
Myocardial Dysfunction in an Animal Model of Cancer Cachexia [PDF]
, 2011 Aims Fatigue is a common occurrence in cancer patients regardless of tumor type or anti-tumor therapies and is an especially problematic symptom in persons with incurable tumor disease.
Crawford, Danielle +7 more
core +2 more sources
Biomarker Research, 2023 Concurrent chemoradiotherapy (cCRT) is the mainstay of treatment for patients diagnosed with locally advanced non-small cell lung cancer (NSCLC). One significant challenge in the effectiveness of this therapy is the potential development of resistance ...
Diego de Miguel-Perez +12 more
doaj +1 more source