Results 21 to 30 of about 75,578 (255)

VMP1, a novel prognostic biomarker, contributes to glioma development by regulating autophagy [PDF]

Journal of Neuroinflammation, 2021
Abstract Background Malignant glioma, especially glioblastoma, is a highly aggressive disease with a dismal prognosis. Vacuole membrane protein 1 (VMP1) is a critical autophagy-associated protein with roles in oncogenesis and tumor progression.
Wanzun Lin, Yun Sun, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu   +5 more
openaire   +3 more sources

Journey to the Center of the Fetal Brain: Environmental Exposures and Autophagy

Frontiers in Cellular Neuroscience, 2018
Fetal brain development is known to be affected by adverse environmental exposures during pregnancy, including infection, inflammation, hypoxia, alcohol, starvation, and toxins.
Jun Lei, Pilar Calvo, Richard Vigh, Irina Burd   +3 more
doaj   +1 more source

New insights into autophagy in inflammatory subtypes of asthma

Frontiers in Immunology, 2023
Asthma is a heterogeneous airway disease characterized by airway inflammation and hyperresponsiveness. Autophagy is a self-degrading process that helps maintain cellular homeostasis.
Hongna Dong, Wei Yang, Wei Li, Simin Zhu, Ling Zhu, Peng Gao, Yuqiu Hao   +6 more
doaj   +1 more source

Development of a Machine Learning-Based Autophagy-Related lncRNA Signature to Improve Prognosis Prediction in Osteosarcoma Patients

Frontiers in Molecular Biosciences, 2021
BackgroundOsteosarcoma is a frequent bone malignancy in children and young adults. Despite the availability of some prognostic biomarkers, most of them fail to accurately predict prognosis in osteosarcoma patients.
Guang-Zhi Zhang, Guang-Zhi Zhang, Guang-Zhi Zhang, Zuo-Long Wu, Zuo-Long Wu, Chun-Ying Li, En-Hui Ren, En-Hui Ren, En-Hui Ren, Wen-Hua Yuan, Wen-Hua Yuan, Ya-Jun Deng, Ya-Jun Deng, Qi-Qi Xie, Qi-Qi Xie, Qi-Qi Xie   +15 more
doaj   +1 more source

Baseline extracellular vesicle miRNA-30c and autophagic CTCs predict chemoradiotherapy resistance and outcomes in patients with lung cancer

Biomarker Research, 2023
Concurrent chemoradiotherapy (cCRT) is the mainstay of treatment for patients diagnosed with locally advanced non-small cell lung cancer (NSCLC). One significant challenge in the effectiveness of this therapy is the potential development of resistance ...
Diego de Miguel-Perez, Francisco Gabriel Ortega, Rosario Guerrero Tejada, Antonio Martínez-Única, Christine B. Peterson, Alessandro Russo, Muthukumar Gunasekaran, Andres F. Cardona, Victor Amezcua, Jose Antonio Lorente, Jose Expósito Hernández, Christian Rolfo, Maria Jose Serrano   +12 more
doaj   +1 more source

The regulatory roles of circular RNAs via autophagy in ischemic stroke

Frontiers in Neurology, 2022
Ischemic stroke (IS) is a severe disease with a high disability, recurrence, and mortality rates. Autophagy, a highly conserved process that degrades damaged or aging organelles and excess cellular components to maintain homeostasis, is activated during ...
Xiaoqin Li, Lingfei Li, Xiaoli Si, Zheng Zhang, Zhumei Ni, Yongji Zhou, Keqin Liu, Wenqing Xia, Yuyao Zhang, Xin Gu, Jinyu Huang, Congguo Yin, Congguo Yin, Anwen Shao, Anwen Shao, Lin Jiang, Lin Jiang   +16 more
doaj   +1 more source

Identification of a Novel Defined Immune-Autophagy-Related Gene Signature Associated With Clinical and Prognostic Features of Kidney Renal Clear Cell Carcinoma

Frontiers in Molecular Biosciences, 2021
Background: As a common cancer of the urinary system in adults, renal clear cell carcinoma is metastatic in 30% of patients, and 1–2 years after diagnosis, 60% of patients die.
Guangyuan Zhang, Guangyuan Zhang, Lei Zhang, Lei Zhang, Si Sun, Ming Chen, Ming Chen, Ming Chen   +7 more
doaj   +1 more source

Identification of Six Autophagy-Related-lncRNA Prognostic Biomarkers in Uveal Melanoma [PDF]

Disease Markers, 2021
Currently, no autophagy-related long noncoding RNA (lncRNA) has been reported to predict the prognosis of uveal melanoma patients. Our study screened for autophagy-related lncRNAs in 80 samples downloaded from The Cancer Genome Atlas (TCGA) database through lncRNA-mRNA coexpression. We used univariate Cox to further filter the lncRNAs. Multivariate Cox
Yao Chen, Lu Chen, Jinwei Wang, Jia Tan, Sha Wang   +4 more
openaire   +2 more sources

Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot

Biology, 2020
Autophagy is a highly conserved degradation mechanism that is essential for maintaining cellular homeostasis. In human disease, autophagy pathways are frequently deregulated and there is immense interest in targeting autophagy for therapeutic approaches.
Magali Humbert, María Morán, Patricia de la Cruz-Ojeda, Jordi Muntané, Tabea Wiedmer, Nadezda Apostolova, Sharon L. McKenna, Guillermo Velasco, Walter Balduini, Leopold Eckhart, Bassam Janji, Belém Sampaio-Marques, Paula Ludovico, Eva Žerovnik, Rupert Langer, Aurel Perren, Nikolai Engedal, Mario P. Tschan   +17 more
doaj   +1 more source

Identification of autophagy‐related biomarker and analysis of immune infiltrates in oral carcinoma

Journal of Clinical Laboratory Analysis, 2022
AbstractBackgroundAutophagy plays a vital role in the progression of the tumor. We aimed to investigate the expression, prognostic value, and immune infiltration of autophagy‐related genes in oral carcinoma via bioinformatics analysis.MethodsThe microarray datasets (GSE146483 and GSE23558) of oral carcinoma were downloaded from Gene Expression Omnibus (
Honghai Fu, Dianguo Zhao, Legang Sun, Yumei Huang, Xiangrui Ma   +4 more
openaire   +2 more sources