Results 1 to 10 of about 116,566 (305)

Prognostic impact of autophagy biomarkers for cutaneous melanoma. [PDF]

Frontiers in Oncology, 2016
Prognosis and survival for malignant melanoma is highly dependent on early diagnosis and treatment. While the American Joint Committee on Cancer (AJCC) criteria provides a means of staging melanomas and guiding treatment approaches, it is unable to ...
Diana Yao Li Tang, Robert Ellis, Robert Ellis, Penny Lovat   +3 more
doaj   +6 more sources

Role of Autophagy Biomarkers In Burn-Age Estimation and Progression. [PDF]

Acad Forensic Pathol, 2019
Background: Determination of time passed since burn injury in the living is critical in forensic science. Autophagy biomarkers and vitronectin can play an important role in determination of the age of burn injuries through their levels in the tissue.
Yassa HA, Hanna RT, El Abdin HZ.
europepmc   +4 more sources

Autophagy-related IFNG is a prognostic and immunochemotherapeutic biomarker of COAD patients

Frontiers in Immunology, 2023
BackgroundNumerous studies have shown autophagy affects cellular immune responses. This study aims to explore prognosis and immunotherapeutic biomarkers related to autophagy in colon adenocarcinoma (COAD).MethodsBased on R software, we performed the ...
Taohua Yue, Yunlong Cai, Jing Zhu, Yucun Liu, Shanwen Chen, Pengyuan Wang, Long Rong   +6 more
doaj   +3 more sources

Comprehensive machine learning and experimental verification reveal the mechanism of action of autophagy-related genes FIZ1 and FBXO21 in acute kidney injury [PDF]

PeerJ
Background Acute kidney injury (AKI) is a serious disease with a high incidence and easy induction. The search for innovative biomarkers and treatment methods is of great significance for improving the prognosis of patients.
Yunqi Bai, Lili Zhang, Bo Nie, Yixin Su, Jingwei Zhou   +4 more
doaj   +3 more sources

Identification of autophagy-related key biomarkers in caerulein induced acute pancreatitis: In silico and in vivo study. [PDF]

PLoS ONE
BackgroundDysregulated autophagy is known to play a crucial role in the pathogenesis of Acute pancreatitis (AP). However, its specific mechanisms remain unclear.
Xinzhuang Shen, Jie Yao, Zongke Wang, Renhua Chen, Laian Li, Xiangjun Xu, Yongming Huang   +6 more
doaj   +2 more sources

Distinctive autophagy/mitophagy biomarker profiles in frontotemporal lobar degeneration and Alzheimer’s disease

Acta Neuropathologica Communications
Maintaining cellular homeostasis by removing damaged and senescent mitochondria, a process termed mitophagy, is crucial in preventing Alzheimer’s disease (AD) and represents a promising therapeutic target. Our previous research revealed altered mitophagy
Kateřina Veverová, Alžběta Katonová, Hana Horáková, Jan Laczó, Francesco Angelucci, Jakub Hort, Sofie Lautrup, Evandro Fei Fang, Martin Vyhnálek   +8 more
doaj   +4 more sources

Shen-yuan-dan capsule inhibits METTL3-mediated m6A methylation to restore autophagy homeostasis and attenuate post-myocardial infarction heart failure [PDF]

Frontiers in Pharmacology
BackgroundHeart failure (HF) after myocardial infarction (MI) is a serious health issue. This study investigates the therapeutic effects of Shen-Yuan-Dan Capsule (SYD) on post-MI HF and explores its mechanisms, particularly involving m6A modification and
Shuaijie Guo, Shuaijie Guo, Siqi Chen, Siqi Chen, Changxu Xie, Changxu Xie, Sinai Li, Sinai Li, Hongxu Liu, Lei Zhang, Lei Zhang, Weihong Liu, Weihong Liu, Mingxue Zhou, Mingxue Zhou   +14 more
doaj   +2 more sources

Autophagy-related genes are potential diagnostic biomarkers for dermatomyositis [PDF]

Annals of Translational Medicine, 2022
Dermatomyositis (DM) is an autoimmune disease mainly diagnosed by its symptoms and a physical examination, with only some subtypes of DM showing clear molecular changes. To date, few biomarkers have been identified to assess DM progression. Autophagy-related genes have been significantly correlated with inflammation, several types of autoimmune ...
Wang, Le, Fang, Dalang, Liu, Yuan
openaire   +2 more sources

Identification of the relationship between biomarkers of autophagy, apoptosis and inflammation in the acute period of atherothrombotic ischemic stroke

Медицинская иммунология, 2023
The postischemic inflammatory response plays a significant role in the pathogenesis of acute ischemic stroke (IS). It has been established that acute IS is accompanied by aseptic inflammation, which induces the activation of costimulatory molecules in ...
A. V. Lugovaya, N. M. Kalinina, A. M. Ivanov, Yu. V. Nikitin, I. А. Sukhina, V. F. Mitreikin, E. V. Semenova   +6 more
doaj   +1 more source

Tumors Responsive to Autophagy-Inhibition: Identification and Biomarkers [PDF]

Cancers, 2020
Recent advances in cancer treatment modalities reveal the limitations of the prevalent “one-size-fits-all” therapies and emphasize the necessity to develop personalized approaches. In this perspective, identification of predictive biomarkers and intrinsic vulnerabilities are an important advancement for further therapeutic strategies.
Barbeau, Lydie M. O., Keulers, Tom G. H., Rouschop, Kasper M. A.   +2 more
openaire   +3 more sources