Results 11 to 20 of about 116,566 (305)

Identification of Six Autophagy-Related-lncRNA Prognostic Biomarkers in Uveal Melanoma [PDF]

Disease Markers, 2021
Currently, no autophagy-related long noncoding RNA (lncRNA) has been reported to predict the prognosis of uveal melanoma patients. Our study screened for autophagy-related lncRNAs in 80 samples downloaded from The Cancer Genome Atlas (TCGA) database through lncRNA-mRNA coexpression. We used univariate Cox to further filter the lncRNAs. Multivariate Cox
Yao Chen, Lu Chen, Jinwei Wang, Jia Tan, Sha Wang   +4 more
openaire   +2 more sources

Assessment of the dynamics of autophagy and apoptosis biomarkers in the acute period of ischemic stroke using flow cytometry

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2022
The objective was to conduct a comparative analysis of the dynamics of biomarkers of apoptosis and autophagy in the eripheral blood of patients in the acute period of ischemic stroke (IS) and compare it with the dynamics of the severity of neurological ...
A. V. Lugovaya, Yu. V. Emanuel, A. V. Artemova, E. V. Semenova, V. V. Semenova   +4 more
doaj   +1 more source

Atg16L1 as a Novel Biomarker and Autophagy Gene for Diabetic Retinopathy [PDF]

Journal of Diabetes Research, 2021
Objective. Accumulating evidence suggests the critical role of autophagy in the pathogenesis of diabetic retinopathy (DR). In the current study, we aim to identify autophagy genes involved in DR via microarray analyses. Methods. Gene microarrays were performed to identify differentially expressed lncRNAs/mRNAs between normal and DR retinas.
Xinxiao Gao, Yunhui Du, Wayne Bond Lau, Yu Li, Siquan Zhu, Xin-Liang Ma   +5 more
openaire   +3 more sources

Machine learning and bioinformatics analysis to identify autophagy-related biomarkers in peripheral blood for rheumatoid arthritis

Frontiers in Genetics, 2023
Background: Although rheumatoid arthritis (RA) is a common autoimmune disease, the precise pathogenesis of the disease remains unclear. Recent research has unraveled the role of autophagy in the development of RA.
Guoqi Dong, Hui Gao, Yingqi Chen, Huayuan Yang   +3 more
doaj   +1 more source

Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis [PDF]

International Journal of Molecular Sciences, 2015
Cell death with morphological and molecular features of apoptosis has been detected in osteoarthritic (OA) cartilage, which suggests a key role for chondrocyte death/survival in the pathogenesis of OA. Identification of biomarkers of chondrocyte apoptosis may facilitate the development of novel therapies that may eliminate the cause or, at least, slow ...
Giuseppe Musumeci, Paola Castrogiovanni, Francesca Trovato, Annelie Weinberg, Mohammad Al-Wasiyah, Mohammed Alqahtani, Ali Mobasheri   +6 more
openaire   +4 more sources

An autophagy-related diagnostic biomarker for uterine fibroids: FOS

Frontiers in Medicine, 2023
Uterine fibroids (UFs) are the most common benign gynecologic tumors in reproductive-aged women. The typical diagnostic strategies of UFs are transvaginal ultrasonography and pathological feature, while molecular biomarkers are considered conventional options in the assessment of the origin and development of UFs in recent years. Here, we extracted the
Cai, Lei, Li, Jie, Long, Rui, Liao, Zhiqi, Gong, Juejun, Zheng, Bowen, Zhang, Hanwang   +6 more
openaire   +3 more sources

Unravelling the roles of Autophagy in OSCC: A renewed perspective from mechanisms to potential applications

Frontiers in Pharmacology, 2022
Oral squamous cell carcinoma (OSCC) is associated with a low survival rate and a high disability rate, making it a serious health burden, particularly in Southeast Asian countries.
Qiutong Gou, Ling-Li Zheng, Haixia Huang
doaj   +1 more source

Salinomycin Triggers Human Colorectal Cancer HCT116 Cell Death by Targeting Unfolded Protein Responses and Autophagy Pathways [PDF]

Iranian Journal of Colorectal Research, 2023
Background: Autophagy and the unfolded protein response (UPR) are important pathways in colorectal tumorigenesis and drug resistance, rendering them as potential therapeutic targets for treating this cancer.
Mozhdeh Zamani, Morvarid Siri, Sanaz Dastghaib, Pooneh Mokarram   +3 more
doaj   +1 more source

MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients [PDF]

, 2020
Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the bloodstream.
Dewhurst, T, Hammond, CJ, Topham, CH, Withers, SB   +3 more
core   +2 more sources

VMP1, a novel prognostic biomarker, contributes to glioma development by regulating autophagy [PDF]

Journal of Neuroinflammation, 2021
Abstract Background Malignant glioma, especially glioblastoma, is a highly aggressive disease with a dismal prognosis. Vacuole membrane protein 1 (VMP1) is a critical autophagy-associated protein with roles in oncogenesis and tumor progression.
Wanzun Lin, Yun Sun, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu   +5 more
openaire   +3 more sources