Results 11 to 20 of about 75,578 (255)

Identification of the relationship between biomarkers of autophagy, apoptosis and inflammation in the acute period of atherothrombotic ischemic stroke

Медицинская иммунология, 2023
The postischemic inflammatory response plays a significant role in the pathogenesis of acute ischemic stroke (IS). It has been established that acute IS is accompanied by aseptic inflammation, which induces the activation of costimulatory molecules in ...
A. V. Lugovaya, N. M. Kalinina, A. M. Ivanov, Yu. V. Nikitin, I. А. Sukhina, V. F. Mitreikin, E. V. Semenova   +6 more
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Assessment of the dynamics of autophagy and apoptosis biomarkers in the acute period of ischemic stroke using flow cytometry

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2022
The objective was to conduct a comparative analysis of the dynamics of biomarkers of apoptosis and autophagy in the eripheral blood of patients in the acute period of ischemic stroke (IS) and compare it with the dynamics of the severity of neurological ...
A. V. Lugovaya, Yu. V. Emanuel, A. V. Artemova, E. V. Semenova, V. V. Semenova   +4 more
doaj   +1 more source

Machine learning and bioinformatics analysis to identify autophagy-related biomarkers in peripheral blood for rheumatoid arthritis

Frontiers in Genetics, 2023
Background: Although rheumatoid arthritis (RA) is a common autoimmune disease, the precise pathogenesis of the disease remains unclear. Recent research has unraveled the role of autophagy in the development of RA.
Guoqi Dong, Hui Gao, Yingqi Chen, Huayuan Yang   +3 more
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An autophagy-related diagnostic biomarker for uterine fibroids: FOS

Frontiers in Medicine, 2023
Uterine fibroids (UFs) are the most common benign gynecologic tumors in reproductive-aged women. The typical diagnostic strategies of UFs are transvaginal ultrasonography and pathological feature, while molecular biomarkers are considered conventional options in the assessment of the origin and development of UFs in recent years. Here, we extracted the
Cai, Lei, Li, Jie, Long, Rui, Liao, Zhiqi, Gong, Juejun, Zheng, Bowen, Zhang, Hanwang   +6 more
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Unravelling the roles of Autophagy in OSCC: A renewed perspective from mechanisms to potential applications

Frontiers in Pharmacology, 2022
Oral squamous cell carcinoma (OSCC) is associated with a low survival rate and a high disability rate, making it a serious health burden, particularly in Southeast Asian countries.
Qiutong Gou, Ling-Li Zheng, Haixia Huang
doaj   +1 more source

Salinomycin Triggers Human Colorectal Cancer HCT116 Cell Death by Targeting Unfolded Protein Responses and Autophagy Pathways [PDF]

Iranian Journal of Colorectal Research, 2023
Background: Autophagy and the unfolded protein response (UPR) are important pathways in colorectal tumorigenesis and drug resistance, rendering them as potential therapeutic targets for treating this cancer.
Mozhdeh Zamani, Morvarid Siri, Sanaz Dastghaib, Pooneh Mokarram   +3 more
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Identification and Analysis of Potential Autophagy-Related Biomarkers in Endometriosis by WGCNA [PDF]

Frontiers in Molecular Biosciences, 2021
Background: Endometriosis is a serious gynecological disorder characterized by debilitating pain, infertility and the establishment of innervated endometriosis lesions outside the uterus. Early detection and accurate diagnosis are pivotal in endometriosis.
Jing Wang, Shanshan Cong, Han Wu, Yanan He, Xiaoli Liu, Liyuan Sun, Xibo Zhao, Guangmei Zhang   +7 more
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Clustering analysis revealed the autophagy classification and potential autophagy regulators' sensitivity of pancreatic cancer based on multi‐omics data

Cancer Medicine, 2023
Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy and is unresponsive to conventional therapeutic modalities due to its high heterogeneity, expounding the necessity, and priority of searching for effective biomarkers and drugs ...
Yonghao Chen, Jialin Meng, Xiaofan Lu, Xiao Li, Chunhui Wang   +4 more
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Identification and verification of three autophagy-related genes as potential biomarkers for the diagnosis of psoriasis

Scientific Reports, 2023
Psoriasis vulgaris is the most common form of the four clinical types. However, early diagnosis of psoriasis vulgaris is difficult due to the lack of effective biomarkers.
Ailing Zou, Yongjun Chen, Tangsheng Liu, Ting Yang, Bei Zhou   +4 more
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FRI0515 HSP90AA1, A CHAPERONE-MEDIATED AUTOPHAGY, IS A BIOMARKER ASSOCIATED WITH DEFECTIVE AUTOPHAGY IN OSTEOARTHRITIS [PDF]

Annals of the Rheumatic Diseases, 2019
Background In osteoarthritis (OA), defects in cellular homeostasis, such as autophagy, are evident and precede joint damage (1). We have shown that there is a defect in autophagy in OA human chondrocytes and cartilage (2). Indeed, pharmacological activation of autophagy protects against joint damage (3).
Irene Lorenzo, Jose Antonio Pinto Tasende, Natividad Oreiro, Francisco J. Blanco, Beatriz Carames   +4 more
openaire   +1 more source