Results 31 to 40 of about 75,578 (255)

Autophagy-related genes are potential diagnostic and prognostic biomarkers in prostate cancer [PDF]

Translational Andrology and Urology, 2020
Recently, autophagy was found related to several malignances.To explore the diagnostic and prognostic values of autophagy in prostate cancer (PCa), we first identified differentially expressed autophagy-related genes (DEARGs) based on The Cancer Genome Atlas (TCGA) Prostate Adenocarcinoma (PRAD) dataset.
Cheng, Yifei, Qi, Feng, Li, Lu, Qin, Zongshi, Li, Xiao, Wang, Xinwei   +5 more
openaire   +2 more sources

Non-coding RNAs: The recently accentuated molecules in the regulation of cell autophagy for ovarian cancer pathogenesis and therapeutic response

Frontiers in Pharmacology, 2023
Autophagy is a self-recycling and conserved process, in which the senescent cytoplasmic components are degraded in cells and then recycled to maintain homeostatic balance.
Bi Peng, Jing Li, Yuanliang Yan, Yuanhong Liu, Qiuju Liang, Qiuju Liang, Wei Liu, Wei Liu, Abhimanyu Thakur, Kui Zhang, Zhijie Xu, Jian Wang, Fan Zhang   +12 more
doaj   +1 more source

Novel diagnostic biomarkers regulating macrophages autophagy in ischemic cardiomyopathy: An analysis integrating bulk RNA sequencing with single-cell RNA sequencing

Immunobiology
Macrophage autophagy plays a pivotal role in ischemia cardiomyopathy (ICM). However, the underlying mechanisms and macrophage autophagy-related biomarkers in ICM have not been elucidated.
Weiluan Cen, Yajin Pan, Yaohan Tang, Jianing Yu, Yixuan Xuan, Jingyu Huang, Shanshan Wei, Jianfeng Zhang   +7 more
doaj   +1 more source

FRI0540 Identification of biomarkers of oa associated to defective autophagy [PDF]

Annals of the Rheumatic Diseases, 2018
Background In osteoarthritis (OA), defects in cellular homeostasis, and in particular in autophagy, are evident and precede joint damage. In this sense, we have shown that there is a defect in autophagy in OA human chondrocytes and cartilage, and pharmacological activation of autophagy protects against joint damage.
I. Lorenzo-Gomez, N. Oreiro, J.A. Pinto-Tasende, F.J. Blanco, B. Carames   +4 more
openaire   +1 more source

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology
Autophagy is an evolutionarily conserved lysosomal degradation pathway that maintains cellular homeostasis by eliminating dysfunctional organelles and protein aggregates.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The dynamics of biomarkers of autophagy and neuroinflammation in the acute period of atherothrombotic ischemic stroke

Медицинская иммунология
Postischemic neuroinflammation is a critical pathophysiological process within the entire pattern of cerebral ischemia. It is characterized by microglial and astroglial activation and is accompanied by disturbances in the innate and adaptive immune ...
A. V. Lugovaya, N. M. Kalinina, A. M. Ivanov, Yu. V. Nikitin, I. A. Sukhina, V. P. Mitreikin, S. Sh. Zabirov, G. E. Kirilkin   +7 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Identification of DAPK1 as an autophagy-related biomarker for myotonic dystrophy type 1

Frontiers in Genetics, 2022
Myotonic dystrophy type I (DM1), a CTG repeat expansion hereditary disorder, is primarily characterized by myotonia. Several studies have reported that abnormal autophagy pathway has a close relationship with DM1. However, the underlying key regulatory molecules dictating autophagy disturbance still remains elusive.
Min Hu, Meng-Ru Ge, Hong-Xia Li, Bei Zhang, Gang Li   +4 more
openaire   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source