Results 11 to 20 of about 99,381 (174)

Autoradiography reveals regional metabolic differences in the endometrium of pregnant and nonpregnant mice

Brazilian Journal of Medical and Biological Research, 1998
The rodent endometrium undergoes remarkable modifications during pregnancy, resulting from a redifferentiation of its fibroblasts. During this modification (decidualization), the fibroblasts transform into large, polyhedral cells that establish ...
S.F. Oliveira, P. Abrahamsohn, T.M.T. Zorn   +2 more
doaj   +1 more source

Mechanistic Insights into the Stimulant Properties of Novel Psychoactive Substances (NPS) and Their Discrimination by the Dopamine Transporter—In Silico and In Vitro Exploration of Dissociative Diarylethylamines

Brain Sciences, 2018
Novel psychoactive substances (NPS) may have unsuspected addiction potential through possessing stimulant properties. Stimulants normally act at the dopamine transporter (DAT) and thus increase dopamine (DA) availability in the brain, including nucleus ...
Michelle A. Sahai, Colin Davidson, Neelakshi Dutta, Jolanta Opacka-Juffry   +3 more
doaj   +1 more source

Receptor localization of steroid hormones and drugs: discoveries through the use of thaw-mount and dry-mount autoradiography

Brazilian Journal of Medical and Biological Research, 1998
The history of receptor autoradiography, its development and applications, testify to the utility of this histochemical technique for localizing radiolabeled hormones and drugs at cellular and subcellular sites of action in intact tissues.
W.E. Stumpf
doaj   +1 more source

Modification of dopamine neurotransmission in the nucleus accumbens of rats deficient in n–3 polyunsaturated fatty acids

Journal of Lipid Research, 2000
We studied the effects of a diet chronically deficient in α-linolenic acid, the precursor of long-chain n–3 polyunsaturated fatty acids, on dopaminergic neurotransmission in the shell region of the nucleus accumbens of rats.
Luc Zimmer, Sylvie Delion-Vancassel, Georges Durand, Denis Guilloteau, Sylvie Bodard, Jean-Claude Besnard, Sylvie Chalon   +6 more
doaj   +1 more source

Uranium Traps in Phreatic Sandstone-type Prospect, Taunsa Area, Dera Ghazi Khan, Eastern Sulaiman Range, Pakistan: Evidences from Autoradiography and Optical Microscopy

International Journal of Economic and Environment Geology, 2020
Taunsa uranium occurrence like other uranium resources in Pakistan is hosted by the Late Miocene-Pliocene age Litra Formation of the Siwalik Group molasse sediments.
Rahman Ullah, Nie Fengjuin, Zhang Xin, Zhang Chengyong, Asim Ali, Zhang Pengfei
doaj   +1 more source

[¹²⁵I]INFT: Synthesis and Evaluation of a New Imaging Agent for Tau Protein in Post-Mortem Human Alzheimer’s Disease Brain

Molecules, 2023
Aggregation of Tau protein into paired helical filaments causing neurofibrillary tangles (NFT) is a neuropathological feature in Alzheimer’s disease (AD).
Roz R. Limpengco, Christopher Liang, Yasmin K. Sandhu, Jogeshwar Mukherjee   +3 more
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Imaging of Gα_q Proteins in Mouse and Human Organs and Tissues

Pharmaceutics, 2022
G protein-coupled receptors (GPCRs) transfer extracellular signals across cell membranes by activating intracellular heterotrimeric G proteins. Several studies suggested G proteins as novel drug targets for the treatment of complex diseases, e.g., asthma
Jan H. Voss, Haneen Al-Hroub, Robin Gedschold, Jennifer M. Dietrich, Evelyn Gaffal, Marieta Toma, Stefan Kehraus, Gabriele M. König, Peter Brust, Bernd K. Fleischmann, Daniela Wenzel, Winnie Deuther-Conrad, Christa E. Müller   +12 more
doaj   +1 more source

Non-invasive in vivo imaging of porcine islet xenografts in a preclinical model with [68Ga]Ga-exendin-4

Frontiers in Nuclear Medicine, 2023
IntroductionIslet xenotransplantation may be a therapeutic option in type 1 diabetes. Recent advances in generating genetically modified source pigs offer advantages as immune suppressants can potentially be eliminated after the transplantation.
Felix Lindheimer, Magdalena Julia Lindner, Rosel Oos, Mohsen Honarpisheh, Yichen Zhang, Yutian Lei, Lelia Wolf-van Buerck, Franz Josef Gildehaus, Simon Lindner, Peter Bartenstein, Elisabeth Kemter, Elisabeth Kemter, Elisabeth Kemter, Eckhard Wolf, Eckhard Wolf, Eckhard Wolf, Jochen Seissler, Sibylle Ziegler   +17 more
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Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ1 Receptors in the Brain

Pharmaceuticals, 2014
Sharpless asymmetric dihydroxylation of styrene derivative 6 afforded chiral triols (R)-7 and (S)-7, which were cyclized with tosyl chloride in the presence of Bu2SnO to provide 2-benzopyrans (R)-4 and (S)-4 with high regioselectivity.
Katharina Holl, Dirk Schepmann, Steffen Fischer, Friedrich-Alexander Ludwig, Achim Hiller, Cornelius K. Donat, Winnie Deuther-Conrad, Peter Brust, Bernhard Wünsch   +8 more
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In Vitro and In Vivo Characterization of Dibenzothiophene Derivatives [¹²⁵I]Iodo-ASEM and [¹⁸F]ASEM as Radiotracers of Homo- and Heteromeric α7 Nicotinic Acetylcholine Receptors

Molecules, 2020
The α7 nicotinic acetylcholine receptor (α7 nAChR) is involved in several cognitive and physiologic processes; its expression levels and patterns change in neurologic and psychiatric diseases, such as schizophrenia and Alzheimer’s disease,
Cornelius K. Donat, Henrik H. Hansen, Hanne D. Hansen, Ronnie C. Mease, Andrew G. Horti, Martin G. Pomper, Elina T. L’Estrade, Matthias M. Herth, Dan Peters, Gitte M. Knudsen, Jens D. Mikkelsen   +10 more
doaj   +1 more source