Results 11 to 20 of about 193,799 (312)

A Novel Closo-Ortho-Carborane-Based Glucosamine Derivative as a Promising Agent for Boron Neutron Capture Therapy [PDF]

Pharmaceuticals
Background: Boron Neutron Capture Therapy (BNCT) is a promising cancer treatment that combines tumor-selective boron delivery agents with thermal neutrons to kill cancer cells while sparing normal tissue.
Daniela Imperio, Ian Postuma, Salvatore Villani, Erika Del Grosso, Laura Cansolino, Cinzia Ferrari, Silvia Fallarini, Silva Bortolussi, Luigi Panza   +8 more
doaj   +2 more sources

HIGH-RESOLUTION AUTORADIOGRAPHY [PDF]

, 1962
Methods used in obtaining high resolution in autoradiography, with special emphasis on the technique of electron microscopic autoradiography, are described, together with control experiments designed to establish the optimum conditions or procedures.
G. Lucien, Robert P. van Tubergen
openalex   +2 more sources

Down-Regulation of Toll-Like Receptor 5 (TLR5) Increased VEGFR Expression in Triple Negative Breast Cancer (TNBC) Based on Radionuclide Imaging

Frontiers in Oncology, 2021
In this study, GFP-tagged TNBC 4T1 cells with down-regulated TLR5 expression (TLR5− 4T1) and normal TLR5 expression (TLR5+ 4T1) were constructed, respectively.
Wen Jiang, Yeming Han, Ting Liang, Chao Zhang, Feng Gao, Guihua Hou   +5 more
doaj   +1 more source

Superiority of Formalin-Fixed Paraffin-Embedded Brain Tissue for in vitro Assessment of Progressive Supranuclear Palsy Tau Pathology With [18F]PI-2620

Frontiers in Neurology, 2021
Objectives: Autoradiography on brain tissue is used to validate binding targets of newly discovered radiotracers. The purpose of this study was to correlate quantification of autoradiography signal using the novel next-generation tau positron emission ...
Marie Willroider, Sigrun Roeber, Anja K. E. Horn, Thomas Arzberger, Thomas Arzberger, Maximilian Scheifele, Gesine Respondek, Osama Sabri, Henryk Barthel, Marianne Patt, Olena Mishchenko, Andreas Schildan, André Mueller, Norman Koglin, Andrew Stephens, Johannes Levin, Johannes Levin, Johannes Levin, Günter U. Höglinger, Günter U. Höglinger, Günter U. Höglinger, Günter U. Höglinger, Peter Bartenstein, Peter Bartenstein, Jochen Herms, Jochen Herms, Matthias Brendel, Matthias Brendel, Leonie Beyer, Leonie Beyer   +29 more
doaj   +1 more source

Nuclear Melt Glass from Experimental Field, Semipalatinsk Test Site

Energies, 2022
Investigation of shocked materials provides unique information about behavior of substances in extreme thermodynamic conditions. Near surface nuclear tests have induced multiple transformations of affected soils. Examination of nuclear glasses and relics
Irina E. Vlasova, Vasily O. Yapaskurt, Alexei A. Averin, Oleg E. Melnik, Denis A. Zolotov, Roman A. Senin, Tatiana R. Poliakova, Iurii M. Nevolin, Stepan N. Kalmykov, Andrey A. Shiryaev   +9 more
doaj   +1 more source

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

Design, Synthesis, and Validation of a Novel [¹¹C]Promethazine PET Probe for Imaging Abeta Using Autoradiography

Molecules, 2021
Promethazine, an antihistamine drug used in the clinical treatment of nausea, has been demonstrated the ability to bind Abeta in a transgenic mouse model of Alzheimer’s disease.
Clayton A. Whitmore, Mariam I. Boules, William J. Behof, Justin R. Haynes, Dmitry Koktysh, Adam J. Rosenberg, Mohammed N. Tantawy, Wellington Pham   +7 more
doaj   +1 more source

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

The Role of Dopamine in the Stimulant Characteristics of Novel Psychoactive Substances (NPS)—Neurobiological and Computational Assessment Using the Case of Desoxypipradrol (2-DPMP)

Frontiers in Pharmacology, 2020
Stimulant drugs, including novel psychoactive substances (NPS, formerly “legal highs”) have addictive potential which their users may not realize. Stimulants increase extracellular dopamine levels in the brain, including the reward and addiction pathways,
Barbara Loi, Barbara Loi, Michelle A. Sahai, Maria Antonietta De Luca, Hana Shiref, Jolanta Opacka-Juffry   +5 more
doaj   +1 more source

High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling

Frontiers in Public Health, 2023
BackgroundPrevious research has outlined the health benefits of exercise including its therapeutic potential for substance use disorders (SUD). These data have already been utilized and it is now common to find exercise as part of SUD treatment and ...
John Tyler, John Tyler, Madeline Podaras, Madeline Podaras, Brittany Richardson, Brittany Richardson, Nicole Roeder, Nicole Roeder, Nikki Hammond, John Hamilton, Kenneth Blum, Mark Gold, David A. Baron, Panayotis K. Thanos, Panayotis K. Thanos   +14 more
doaj   +1 more source