Results 21 to 30 of about 133,686 (278)

Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue

Acta Neuropathologica Communications, 2019
[F-18]-MK-6240, a novel tau positron emission tomography (PET) tracer recently discovered for the in vivo detection of neurofibrillary tangles, has the potential to improve diagnostic accuracy in the detection of Alzheimer disease.
Cinthya Aguero, M. Dhaynaut, M. Normandin, A. Amaral, N. Guehl, R. Neelamegam, M. Marquié, Keith A. Johnson, G. El Fakhri, M. Frosch, T. Gómez-Isla   +10 more
semanticscholar   +1 more source

Mechanistic Insights into the Stimulant Properties of Novel Psychoactive Substances (NPS) and Their Discrimination by the Dopamine Transporter—In Silico and In Vitro Exploration of Dissociative Diarylethylamines

Brain Sciences, 2018
Novel psychoactive substances (NPS) may have unsuspected addiction potential through possessing stimulant properties. Stimulants normally act at the dopamine transporter (DAT) and thus increase dopamine (DA) availability in the brain, including nucleus ...
Michelle A. Sahai, Colin Davidson, Neelakshi Dutta, Jolanta Opacka-Juffry   +3 more
doaj   +1 more source

Uranium Traps in Phreatic Sandstone-type Prospect, Taunsa Area, Dera Ghazi Khan, Eastern Sulaiman Range, Pakistan: Evidences from Autoradiography and Optical Microscopy

International Journal of Economic and Environment Geology, 2020
Taunsa uranium occurrence like other uranium resources in Pakistan is hosted by the Late Miocene-Pliocene age Litra Formation of the Siwalik Group molasse sediments.
Rahman Ullah, Nie Fengjuin, Zhang Xin, Zhang Chengyong, Asim Ali, Zhang Pengfei
doaj   +1 more source

Cortical laminar tau deposits and activated astrocytes in Alzheimer’s disease visualised by 3H-THK5117 and 3H-deprenyl autoradiography

Scientific Reports, 2017
Hyperphosphorylated tau protein deposits and, inflammatory processes are characteristic components of Alzheimer disease (AD) pathology. We here aimed to visualize in vitro the distribution of tau deposits and activated astrocytes across the cortical ...
L. Lemoine, L. Saint‐Aubert, I. Nennesmo, P. Gillberg, A. Nordberg   +4 more
semanticscholar   +1 more source

Receptor localization of steroid hormones and drugs: discoveries through the use of thaw-mount and dry-mount autoradiography

Brazilian Journal of Medical and Biological Research, 1998
The history of receptor autoradiography, its development and applications, testify to the utility of this histochemical technique for localizing radiolabeled hormones and drugs at cellular and subcellular sites of action in intact tissues.
W.E. Stumpf
doaj   +1 more source

In Vitro and In Vivo Characterization of Dibenzothiophene Derivatives [¹²⁵I]Iodo-ASEM and [¹⁸F]ASEM as Radiotracers of Homo- and Heteromeric α7 Nicotinic Acetylcholine Receptors

Molecules, 2020
The α7 nicotinic acetylcholine receptor (α7 nAChR) is involved in several cognitive and physiologic processes; its expression levels and patterns change in neurologic and psychiatric diseases, such as schizophrenia and Alzheimer’s disease,
Cornelius K. Donat, Henrik H. Hansen, Hanne D. Hansen, Ronnie C. Mease, Andrew G. Horti, Martin G. Pomper, Elina T. L’Estrade, Matthias M. Herth, Dan Peters, Gitte M. Knudsen, Jens D. Mikkelsen   +10 more
doaj   +1 more source

Non-invasive in vivo imaging of porcine islet xenografts in a preclinical model with [68Ga]Ga-exendin-4

Frontiers in Nuclear Medicine, 2023
IntroductionIslet xenotransplantation may be a therapeutic option in type 1 diabetes. Recent advances in generating genetically modified source pigs offer advantages as immune suppressants can potentially be eliminated after the transplantation.
Felix Lindheimer, Magdalena Julia Lindner, Rosel Oos, Mohsen Honarpisheh, Yichen Zhang, Yutian Lei, Lelia Wolf-van Buerck, Franz Josef Gildehaus, Simon Lindner, Peter Bartenstein, Elisabeth Kemter, Elisabeth Kemter, Elisabeth Kemter, Eckhard Wolf, Eckhard Wolf, Eckhard Wolf, Jochen Seissler, Sibylle Ziegler   +17 more
doaj   +1 more source

Combined [18F]DPA-714 micro-positron emission tomography and autoradiography imaging of microglia activation after closed head injury in mice

Journal of Neuroinflammation, 2016
BackgroundTraumatic brain injury (TBI) is a major cause of death and disability. Neuroinflammation contributes to acute damage after TBI and modulates long-term evolution of degenerative and regenerative responses to injury.
I. Israel, Andrea Ohsiek, E. Al‐Momani, C. Albert‐Weissenberger, C. Stetter, S. Mencl, A. Buck, C. Kleinschnitz, S. Samnick, A. Sirén   +9 more
semanticscholar   +1 more source

A Quantitative Particle Identification (QPID) spectral autoradiography system. [PDF]

Commun Eng
Autoradiography is used to study the distribution and binding of radioisotope tagged ligands in tissue at microscale among other applications. The technology has evolved since its inception when it used analogue film exposure techniques with the ...
Adler SS, Sato N, Baidoo KE, Lin FI, Lee W, Olkowski CP, Escorcia FE, Choyke PL.   +7 more
europepmc   +2 more sources

Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography.

Brain : a journal of neurology, 2007
Understanding the long association pathways that convey cortical connections is a critical step in exploring the anatomic substrates of cognition in health and disease.
J. Schmahmann, D. Pandya, Ruopeng Wang, G. Dai, H. D'Arceuil, A. de Crespigny, V. Wedeen   +6 more
semanticscholar   +1 more source