Results 61 to 70 of about 99,381 (174)
Advanced Science, Volume 13, Issue 3, 14 January 2026.Alzheimer's disease (AD) is the most common neurodegenerative disorder. This study demonstrates that microglial Rack1 deficiency decreased Aβ deposition and neuroinflammation and ameliorated cognitive impairments in AD model mice by enhancing IGF1‐mediated astrocytic phagocytosis.
Jingdan Zhang +13 more
wiley +1 more source
ChemBioChem, Volume 27, Issue 1, January 2026.At the intersection of chemical biology, plant imaging, and contemporary art, this review introduces the concept of chembioart. By tracing how chemical reporters illuminate plant biomolecules in vivo, their role not only in advancing scientific understanding but also in inspiring transdisciplinary collaborations and visual expression is highlighted ...
Marie Hinnebo +4 more
wiley +1 more source
Journal of Cellular Physiology, Volume 241, Issue 1, January 2026.ABSTRACT Patients with chronic kidney disease, and particularly those under hemodialysis, are prone to develop cardiovascular complications, mostly due to the exacerbation of vascular calcification. Vascular calcification relies on the transdifferentiation of vascular smooth muscle cells into calcifying cells.
Najwa Skafi +16 more
wiley +1 more source
The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.Abstract Miricorilant is a novel selective glucocorticoid receptor (GR) modulator with mixed agonist/antagonist effects at the GR and modest antagonism at the mineralocorticoid receptor that is being developed for the treatment of metabolic dysfunction‐associated steatohepatitis.
Hazel J. Hunt +3 more
wiley +1 more source
Oxytocin Receptor Binding Sites in the Periphery of the Neonatal Prairie Vole
Frontiers in Neuroscience, 2019 The oxytocin receptor (OXTR) has been observed in the periphery of neonatal C57BL/6J mice (Mus musculus), including facial regions and the anogenital area.
Maria A. Greenwood +3 more
doaj +1 more source
Journal of Labelled Compounds and Radiopharmaceuticals, Volume 69, Issue 1, January 2026.[125I]CTAU, a new analog of [18F]T807, was found to be suitable for imaging tau protein in postmortem human Alzheimer's disease brain slices. [125I]CTAU may be among the smaller ring structures that bind to tau protein. ABSTRACT The aim of this study was to further understand the tau imaging agent, flortaucipir (T807), by making small modifications and
Chloe C. McNamara +5 more
wiley +1 more source
Pharmaceuticals, 2014 Cannabinoid receptor subtype 2 (CB2) has been shown to be up-regulated in activated microglia and therefore plays an important role in neuroinflammatory and neurodegenerative diseases such as multiple sclerosis, amyotrophic lateral sclerosis and ...
Linjing Mu +8 more
doaj +1 more source
Mass spectrometry in ocular drug research
Mass Spectrometry Reviews, Volume 45, Issue 1, Page 37-68, January/February 2026.Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo +6 more
wiley +1 more source
CB1 and LPA1 Receptors Relationship in the Mouse Central Nervous System
Frontiers in Molecular Neuroscience, 2019 Neurolipids are a class of bioactive lipids that are produced locally through specific biosynthetic pathways in response to extracellular stimuli. Neurolipids are important endogenous regulators of neural cell proliferation, differentiation, oxidative ...
Estíbaliz González de San Román +11 more
doaj +1 more source
, 2014 Author: Dr. William H. Heidcamp ### Materials 1. ^3H-Thymidine, specific activity of 2.0 - curie/millimole - Onion sets, jars and toothpicks - Alcohol-acetic acid fixative - Materials for feulgen reaction (Exercise 2.4) - Paraffin embedding, sectioning equipment - Kodak Nuclear Track Emulsion (or equivalent) - Darkroom - Water bath at 42° C - Kodak ...
openaire +1 more source