Results 71 to 80 of about 193,799 (312)

COA6 facilitates cytochrome c oxidase biogenesis as thiol-reductase for copper metallochaperones in mitochondria.

, 2020
The mitochondrial cytochrome c oxidase, the terminal enzyme of the respiratory chain, contains heme and copper centers for electron transfer. The conserved COX2 subunit contains the CuA site, a binuclear copper center.
Aich, A., Bogeski, I., Chacinska, A., Chudenkova, M., Deckers, M., Dennerlein, S., Gibhardt, C., Oeljeklaus, S., Pacheu-Grau, D., Rehling, P., Warscheid, B., Wasilewski, M.   +11 more
core   +1 more source

Oxytocin Receptor Binding Sites in the Periphery of the Neonatal Prairie Vole

Frontiers in Neuroscience, 2019
The oxytocin receptor (OXTR) has been observed in the periphery of neonatal C57BL/6J mice (Mus musculus), including facial regions and the anogenital area.
Maria A. Greenwood, Maria A. Greenwood, Elizabeth A. D. Hammock, Elizabeth A. D. Hammock   +3 more
doaj   +1 more source

Non-invasive in vivo imaging of porcine islet xenografts in a preclinical model with [68Ga]Ga-exendin-4

Frontiers in Nuclear Medicine, 2023
IntroductionIslet xenotransplantation may be a therapeutic option in type 1 diabetes. Recent advances in generating genetically modified source pigs offer advantages as immune suppressants can potentially be eliminated after the transplantation.
Felix Lindheimer, Magdalena Julia Lindner, Rosel Oos, Mohsen Honarpisheh, Yichen Zhang, Yutian Lei, Lelia Wolf-van Buerck, Franz Josef Gildehaus, Simon Lindner, Peter Bartenstein, Elisabeth Kemter, Elisabeth Kemter, Elisabeth Kemter, Eckhard Wolf, Eckhard Wolf, Eckhard Wolf, Jochen Seissler, Sibylle Ziegler   +17 more
doaj   +1 more source

Analysis of capecitabine metabolites in conjunction with digital autoradiography in a murine model of pancreatic cancer suggests extensive drug penetration through the tumor

Pharmacology Research & Perspectives, 2022
Previously published digital autoradiography of 3H‐labeled capecitabine reveals a near‐uniform distribution of activity throughout a murine pancreatic model.
James Russell, Louise Fanchon, Hanan Alwaseem, Henrik Molina, Isabella O’Donoghue, Amber Bahr, Elisa deStanchina, Nagavarakishore Pillarsetty, John L. Humm   +8 more
doaj   +1 more source

Holliday junction resolvase in Schizosaccharomyces pombe has identical endonuclease activity to the CCE1 homologue YDC2 [PDF]

, 1998
A novel Holliday junction resolving activity has been identified in fractionated cell extracts of the fission yeast Schizosaccharomyces pombe . The enzyme catalyses endonucleolytic cleavage of Holliday junction-containing chi DNA and synthetic four-way ...
Keeley, A, Oram, M, Tsaneva, IR
core   +2 more sources

Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT2A receptor agonists

British Journal of Pharmacology, EarlyView.
Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s.
Trevor Sharp, Aurelija Ippolito
wiley   +1 more source

Transport of Proteins into Mitochondria [PDF]

, 1980
The mitochondrial ADP/ATP carrier is an integral transmembrane protein of the inner membrane. It is synthesized on cytoplasmic ribosomes. Kinetic data suggested that this protein is transferred into mitochondria in a posttranslational manner.
Allen E. H., Brdiezka D., Chang C. N., Chang C. N., Conboy J. G., Cote C., Date T., Dobberstein B., Flavell R. B., Habermann E., Hackenberg H., Hallermayer G., Harmey M. A., Highfield P. E., Ito K., Klingenberg M., Knoppel E., Korb H., Kreil G., Laemmli U. K., Maccechini M. L., Maccechini M.-L., Mandel G., Marra E., Michel R., Milstein C., Mori M., Nelson N., Pelham H. R. B., Poyton R. O., Poyton R. O., Raymond Y., Schatz G., Sessa G., Shore G. S., Strauss A. W., Vignais P. V., Wickner W., Wickner W., Williams J. C., Zimmermann R., Zimmermann R.   +41 more
core   +1 more source

RNF219 RING Finger Domain Mutants Drive Phase Separation to Encapsulate CCR4‐NOT and Promote Cell Proliferation

Cell Proliferation, EarlyView.
Mutations in the RING finger domain (C3HC4) of RNF219 promote the formation of RNF219 condensates, which are able to encapsulate the CCR4‐NOT complex. These RNF219Mut‐CCR4‐NOT condensates reduce the deacetylation activity of the CCR4‐NOT complex and induce cell proliferation.
Chen Chen, Chenghao Guo, Ke Fang, Chengqi Lin, Zhuojuan Luo   +4 more
wiley   +1 more source

A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.

European Journal of Biochemistry, 1974
A simple method is described for detecting 3H in polyacrylamide gels by scintillation autography (fluorography) using X-ray film. The gel is dehydrated in dimethyl sulphoxide, soaked in a solution of 2,5-diphenyloxazole (PPO) in dimethylsulphoxide, dried
W. Bonner, R. Laskey
semanticscholar   +1 more source

The role of GABA-B in sensorigating processing disorders in rat models, an autoradiographic study [PDF]

, 2019
INTRODUCTION: The process of sensorimotor gating is a neurological phenomenon referring to the brain’s ability to process and filter out stimuli in order to prevent an overflow of information.
Zhuang, Alex
core