Results 71 to 80 of about 133,686 (278)
Automated Mouse Organ Segmentation: A Deep Learning Based Solution [PDF]
arXiv, 2018 The analysis of animal cross section images, such as cross sections of laboratory mice, is critical in assessing the effect of experimental drugs such as the biodistribution of candidate compounds in preclinical drug development stage. Tissue distribution of radiolabeled candidate therapeutic compounds can be quantified using techniques like ...
arxiv
Journal of Neuroscience, 1991 A potent, synthetic cannabinoid was radiolabeled and used to characterize and precisely localize cannabinoid receptors in slide- mounted sections of rat brain and pituitary.
M. Herkenham +5 more
semanticscholar +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Treatment of cancer patients with anthracyclines is known to cause dose‐dependent cardiotoxicity through several mechanisms including enhanced oxidative stress, ultimately resulting in defective excitation–contraction coupling.
Wesam Bassiouni +9 more
wiley +1 more source
Pharmaceuticals, 2014 Cannabinoid receptor subtype 2 (CB2) has been shown to be up-regulated in activated microglia and therefore plays an important role in neuroinflammatory and neurodegenerative diseases such as multiple sclerosis, amyotrophic lateral sclerosis and ...
Linjing Mu +8 more
doaj +1 more source
Localization of Antigens by Autoradiography.
Experimental Biology and Medicine, 1961 SummaryAnalyses of the distribution of isotopically labeled antigens in the animal were combined with autoradiography of the tissues. After intravenous injection of heavily substituted S35-sulfanilazo-bovine γ-globulin into mice, we found protein-bound S35 in the cytoplasm of the Kupffer cells of the liver.
Martha Dicks +5 more
openaire +3 more sources
Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT2A receptor agonists
British Journal of Pharmacology, EarlyView.Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s.
Trevor Sharp, Aurelija Ippolito
wiley +1 more source
CB1 and LPA1 Receptors Relationship in the Mouse Central Nervous System
Frontiers in Molecular Neuroscience, 2019 Neurolipids are a class of bioactive lipids that are produced locally through specific biosynthetic pathways in response to extracellular stimuli. Neurolipids are important endogenous regulators of neural cell proliferation, differentiation, oxidative ...
Estíbaliz González de San Román +11 more
doaj +1 more source
Estimating AutoAntibody Signatures to Detect Autoimmune Disease Patient Subsets [PDF]
arXiv, 2017 Autoimmune diseases are characterized by highly specific immune responses against molecules in self-tissues. Different autoimmune diseases are characterized by distinct immune responses, making autoantibodies useful for diagnosis and prediction. In many diseases, the targets of autoantibodies are incompletely defined.
arxiv
Biological and Pharmaceutical Bulletin, 1995 The process of obtaining 3H-autoradiographic (ARG) images has been expected for a long time. A few X-ray films with no protection layer are commercially available, however, they do not give a reliable image which can be quantitated and can give good contrast.
Naomi Motoji +5 more
openaire +6 more sources
Journal of Neuroendocrinology, EarlyView.Alterations in the expression levels of D2S and D2L resulted in obesity and metabolic syndrome such as abdominal fat accumulation and hyperglycemia in D2L KO mice fed with a high‐fat diet, compared to WT mice. This may be partly due to increased food intake.
Hanna Gonzalez +5 more
wiley +1 more source