Results 71 to 80 of about 99,381 (174)

Validation of Dynamic Deuterium Metabolic Imaging (DMI) for the Measurement of Cerebral Metabolic Rates of Glucose in Rat

NMR in Biomedicine, Volume 39, Issue 1, January 2026.
Deuterium metabolic imaging (DMI) is a novel metabolic imaging technique where 2H MRSI is combined with the administration of 2H‐labeled substrates. Analysis of dynamic DMI is complicated by 2H label losses and kinetic isotope effects. Here, we modified a 13C‐based metabolic model to account for these effects in rat brain and validated DMI flux rates ...
Claudius S. Mathy, Monique A. Thomas, Graeme F. Mason, Robin A. de Graaf, Henk M. De Feyter   +4 more
wiley   +1 more source

Reflections on How Wheat Flour Lipids Impact the Viscoelastic Properties of Gluten Proteins

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 1, January 2026.
ABSTRACT Endogenous wheat flour lipids are known to play an important role in baked product quality, even though they constitute a minor fraction of wheat flour composition. They interact with gluten proteins throughout the different stages of dough processing and therefore contribute to specific quality traits in baked products.
Gamze Yazar, Jozef L. Kokini
wiley   +1 more source

Complementarity of radioautographic and immunohistochemical techniques for localizing neuroreceptors at the light and electron microscopy level

Brazilian Journal of Medical and Biological Research, 1998
To assess relationships between neuropeptide-binding sites and receptor proteins in rat brain, the distribution of radioautographically labeled somatostatin and neurotensin-binding sites was compared to that of immunolabeled sst2A and NTRH receptor ...
Beaudet A.
doaj  

A Novel Closo-Ortho-Carborane-Based Glucosamine Derivative as a Promising Agent for Boron Neutron Capture Therapy

Pharmaceuticals
Background: Boron Neutron Capture Therapy (BNCT) is a promising cancer treatment that combines tumor-selective boron delivery agents with thermal neutrons to kill cancer cells while sparing normal tissue.
Daniela Imperio, Ian Postuma, Salvatore Villani, Erika Del Grosso, Laura Cansolino, Cinzia Ferrari, Silvia Fallarini, Silva Bortolussi, Luigi Panza   +8 more
doaj   +1 more source

Enhanced Radionuclide Therapy via the Conjugation of Pentadecanoic Acids With 225Ac‐ and 177Lu‐Labeled RGD Peptides

Cancer Science, Volume 117, Issue 1, Page 193-202, January 2026.
Radionuclide therapy using PD‐K(225Ac‐DOTA)‐RGD in BxPC‐3‐bearing mice. PD‐K(225Ac‐DOTA)‐RGD successfully suppressed tumor growth. ABSTRACT Improved peptide pharmacokinetics are needed to enhance the therapeutic effects of peptide‐based radionuclide therapy.
Mitsuyoshi Yoshimoto, Shun‐ichi Wada, Yukie Yoshii, Sayaka Hanadate, Anri Inaki, Hirofumi Fujii   +5 more
wiley   +1 more source

RNF219 RING Finger Domain Mutants Drive Phase Separation to Encapsulate CCR4‐NOT and Promote Cell Proliferation

Cell Proliferation, Volume 59, Issue 1, January 2026.
Mutations in the RING finger domain (C3HC4) of RNF219 promote the formation of RNF219 condensates, which are able to encapsulate the CCR4‐NOT complex. These RNF219Mut‐CCR4‐NOT condensates reduce the deacetylation activity of the CCR4‐NOT complex and induce cell proliferation.
Chen Chen, Chenghao Guo, Ke Fang, Chengqi Lin, Zhuojuan Luo   +4 more
wiley   +1 more source

The Development and Application of Tritium-Labeled Compounds in Biomedical Research

Molecules
With low background radiation, tritiate compounds exclusively emit intense beta particles without structural changes. This makes them a useful tool in the drug discovery arsenal.
Yu Teng, Hong Yang, Yulin Tian
doaj   +1 more source

Synthetic trap‐peptides identify a TOM complex phosphatase – PP2A dephosphorylates Tom6

The FEBS Journal, Volume 293, Issue 1, Page 271-294, January 2026.
Synthetic trap‐peptides facilitate the identification of complete holoenzymes that bind to the target sequence remarkably close to the phosphorylation site. PP4 bound to, but did not dephosphorylate, the peptide substrate taken from yeast Tom6 pSer16, showing that proximity alone does not induce phosphatase activity.
Laura Scheinost, Christina Ludwig, Nico Höfflin, Asli Aras Taskin, Adinarayana Marada, F.‐Nora Vögtle, Chris Meisinger, Maja Köhn   +7 more
wiley   +1 more source

Characterization of oxytocin and vasopressin receptors in the Southern giant pouched rat and comparison to other rodents

Frontiers in Endocrinology
Vasopressin and oxytocin are well known and evolutionarily ancient modulators of social behavior. The distribution and relative densities of vasopressin and oxytocin receptors are known to modulate the sensitivity to these signaling molecules ...
Angela R. Freeman, Angela R. Freeman, Samanta Arenas, Danielle N. Lee, Danielle N. Lee, Bhupinder Singh, Bhupinder Singh, Alexander G. Ophir   +7 more
doaj   +1 more source

The Ralstonia solanacearum E3 Ligase Effector RipV1 Targets Plant U‐Box Domain‐Containing Receptor‐Like Cytoplasmic Kinases That Negatively Regulate Immunity in Nicotiana benthamiana

Molecular Plant Pathology, Volume 27, Issue 1, January 2026.
The Ralstonia solanacearum Novel E3 Ligase effector RipV1 ubiquitinates and enhances the accumulation of the plant U‐box‐containing receptor‐like cytoplasmic protein RLCK‐IXb‐1 that negatively regulates immune signalling. ABSTRACT Plants detect microbe‐associated molecular patterns from pathogens via plasma membrane‐localised receptors, which activate ...
Jihyun Choi, Thakshila Dharmasena, Yoonyoung Lee, Jacqueline Monaghan, Cécile Segonzac   +4 more
wiley   +1 more source