Results 91 to 100 of about 4,000 (206)

Estimating Linkage Disequilibrium and Effective Population Size Across Generations in Holstein Cattle

Veterinary Medicine and Science, Volume 11, Issue 6, November 2025.
This study reveals a significant historical decline in effective population size (Ne) in Holstein cattle due to intensive breeding, with recent stabilization reflecting improved genetic management. Maintaining genetic diversity is vital for sustainable dairy cattle breeding programs.
Ronak Salehi, Arash Javanmard, Mahdi Mokhber, Sadegh Alijani   +3 more
wiley   +1 more source

Are autozygosity estimates from imputed genotypes reliable?

, 2022
Estimates of the inbreeding coefficient based on runs of homozygosity (FROH) are widely used in population genetics and livestock studies. The accuracy of FROH estimates is determined in part by the density of the genotyping chip. Compared with high density (HD) chips, low density (LD) chips tend to overestimate FROH in shorter homozygous segments.
Ferenčaković, Maja, Čurik, Ino
openaire   +1 more source

Genomic dissection of inbreeding depression: a gate to new opportunities

Revista Brasileira de Zootecnia
Inbreeding depression, reduction in performance of quantitative traits, including reproduction and survival, caused by inbreeding, is a well-known phenomenon observed in almost all experimental, domesticated, and natural populations.
Ino Curik, Maja Ferenčaković, Johann Sölkner   +2 more
doaj   +1 more source

High Imputation Accuracy Can Be Achieved Using a Small Reference Panel in a Natural Population With Low Genetic Diversity

Molecular Ecology Resources, Volume 25, Issue 8, November 2025.
ABSTRACT Genotype imputation, the inference of missing genotypes using a reference set of population haplotypes, is a cost‐effective tool for improving the quality and quantity of genetic datasets. Imputation is usually applied to large and well‐characterised datasets of humans and livestock, even though it could also benefit smaller natural ...
Hui Zhen Tan, Katarina C. Stuart, Tram Vi, Annabel Whibley, Sarah Bailey, Patricia Brekke, Anna W. Santure   +6 more
wiley   +1 more source

Human spermatogenic failure purges deleterious mutation load from the autosomes and both sex chromosomes, including the gene DMRT1 [PDF]

, 2013
Gonadal failure, along with early pregnancy loss and perinatal death, may be an important filter that limits the propagation of harmful mutations in the human population.
Amorim, Antonio, Aston, Kenneth I., Barros, Alberto, Carracedo, A., Carrell, D.T., Carvalho, Filipa, Conrad, D.F., Dai, Juncheng, Downie, Jonathan, Fernandes, Susana, Gonçalves, João, Guo, Xuejiang, Hu, Z., Huang, N., Hurles, M.E., Lopes, Alexandra, Matthiesen, Rune, Moskovtsev, S., Noordam, Michiel J., Ober, C., Paduch, D.A., Quintela, Ines, Ramu, Avinash, Schiffman, J.D., Schlegel, P.N., Seabra, Catarina, Shah, Jiahao, Sousa, M., Thompson, Emma E, Wilfert, Amy B.   +29 more
core   +3 more sources

A post‐translocation genetic analysis of an endemic wingless grasshopper in urban environments

Conservation Science and Practice, Volume 7, Issue 10, October 2025.
Translocations are increasingly used in conservation, yet invertebrate outcomes remain understudied. This study assessed genetic diversity in a recently translocated flightless grasshopper (Vandiemenella viatica), finding declines in heterozygosity and nucleotide diversity, alongside increased homozygosity in the F2 generation.
Hiromi Yagui, Michael R. Kearney, Thomas L. Schmidt, Ary A. Hoffmann   +3 more
wiley   +1 more source

On the origin of mongrels: evolutionary history of free-breeding dogs in Eurasia [PDF]

, 2015
Although a large part of the global domestic dog population is free-ranging and free- breeding, knowledge of genetic diversity in these free-breeding dogs (FBDs) and their ancestry relations to pure-breed dogs is limited, and indigenous status of FBDs ...
Alagaili, Abdulaziz, Bogdanowicz, Wieslaw, Fadel, Fernanda, Grzybowski, Tomasz, Kaminski, Stanislaw, Klys, Grzegorz, Malewski, Tadeusz, Mills, Daniel, Mohammed, Osama, Moura, Andre, Okhlopkov, Innokentiy, Olenski, Kamil, Pilot, Malgorzata, Rusc, Anna, Suchecka, Ewa   +14 more
core   +1 more source

AUDACITY: A comprehensive approach for the detection and classification of Runs of Homozygosity in medical and population genomics

Computational and Structural Biotechnology Journal, 2020
Runs of Homozygosity (RoHs) are popular among geneticists as the footprint of demographic processes, evolutionary forces and inbreeding in shaping our genome, and are known to confer risk of Mendelian and complex diseases.
Alberto Magi, Tania Giangregorio, Roberto Semeraro, Giulia Carangelo, Flavia Palombo, Giovanni Romeo, Marco Seri, Tommaso Pippucci   +7 more
doaj   +1 more source

Robust diagnostic genetic testing using solution capture enrichment and a novel variant-filtering interface. [PDF]

, 2014
Targeted hybridization enrichment prior to next-generation sequencing is a widespread method for characterizing sequence variation in a research setting, and is being adopted by diagnostic laboratories.
Adlard, J, Bonthron, DT, Camm, N, Carr, IM, Charlton, R, Crinnion, LA, Diggle, CP, Harrison, SM, Lindsay, HA, Morgan, JE, Sheridan, E, Taylor, GR, Watson, CM   +12 more
core   +2 more sources

Estimation of Inbreeding Depression From Overdominant Loci Using Molecular Markers

Evolutionary Applications, Volume 18, Issue 3, March 2025.
ABSTRACT Inbreeding depression is a highly relevant universal phenomenon in population and conservation genetics since it leads to a decline in the fitness of individuals. This phenomenon is due to the homozygous expression of alleles whose effects are hidden in heterozygotes (inbreeding load).
Inés González‐Castellano, Pilar Ordás, Armando Caballero   +2 more
wiley   +1 more source