Investigating the Antiparasitic Potential of the Marine Sesquiterpene Avarone, Its Reduced Form Avarol, and the Novel Semisynthetic Thiazinoquinone Analogue Thiazoavarone [PDF]
Marine Drugs, 2020 The chemical analysis of the sponge Dysidea avara afforded the known sesquiterpene quinone avarone, along with its reduced form avarol. To further explore the role of the thiazinoquinone scaffold as an antiplasmodial, antileishmanial and antischistosomal
Concetta Imperatore +13 more
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Evaluation of the Activity of the Sponge Metabolites Avarol and Avarone and their Synthetic Derivatives Against Fouling Micro- and Macroorganisms [PDF]
Molecules, 2007 The sesquiterpene hydroquinone avarol (1) was isolated from the marine sponge Dysidea avara, whereas the corresponding quinone, avarone (2), was obtained by oxidation of avarol, and the significantly more lipophilic compounds [3’-(p-chloro-phenyl)avarone
Maria Tsoukatou +9 more
doaj +17 more sources
The kinetics of the reduction of the lipophilic quinone avarone by n-alkyl-1,4-dihydronicotinamides of various lipophilicities [PDF]
Journal of the Serbian Chemical Society, 1999 Several NADH model compounds, N-alkyl-1,4-dihydronicotinamides, some of them possessing amphiphilic properties, have been synthesized, and the kinetics of their reaction with a biologically active liphophilic quinone, avarone, has been studied in a ...
MIROSLAV J. GASIC +2 more
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Bioconjugate of lysozyme and the antibacterial marine sesquiterpene quinone avarone and its derivatives. [PDF]
Bioconjug Chem, 2012 A conjugate of lysozyme with avarone, a bioactive sesquiterpene quinone of marine origin, and its three derivatives were synthesized. MALDI TOF mass spectral analysis and tryptic digestion showed that the only residue in lysozyme that was modified by all derivatives was lysine 97.
Novaković I +4 more
europepmc +12 more sources
Evidence of Insulin-Sensitizing and Mimetic Activity of the Sesquiterpene Quinone Avarone, a Protein Tyrosine Phosphatase 1B and Aldose Reductase Dual Targeting Agent from the Marine Sponge Dysidea avara [PDF]
Pharmaceutics, 2023 Type 2 diabetes mellitus (T2DM) is a complex disease characterized by impaired glucose homeostasis and serious long-term complications. First-line therapeutic options for T2DM treatment are monodrug therapies, often replaced by multidrug therapies to ...
Marcello Casertano +10 more
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Simple avarone mimetics as selective agents against multidrug resistant cancer cells [PDF]
European Journal of Medicinal Chemistry, 2016 In this work, synthesis of alkylamino and aralkylamino derivatives of sesquiterpene quinone avarone and its model compound tert-butylquinone was described. For all obtained derivatives biological activity was studied. Cytotoxic activity of the synthesized derivatives towards multidrug resistant MDR human non-small cell lung carcinoma NCI-H460/R cells ...
Jeremić, Marko +6 more
core +17 more sources
Chemical modification of the lectin of the marine coral Gerardia savaglia by marine quinone avarone [PDF]
Journal of the Serbian Chemical Society, 2007 The quinone avarone, isolated from the marine sponge Dysidea avara, possesses the ability to chemically modify proteins. In this work, modification of lectin isolated from the coral Gerardia savaglia by avarone was examined.
IVANA PAJIC +5 more
doaj +6 more sources
The use of bones as tools in Late Lower Paleolithic of Central Italy [PDF]
Scientific ReportsThe Latium area in Italy has yielded rich evidence of Lower Paleolithic sites with both faunal remains, artefacts, and human fossil remains, such as the Ceprano human skull. Many are the sites where lithic industry has been found in association with bone
Flavia Marinelli +2 more
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Cytotoxic Terpene Quinones from Marine Sponges [PDF]
Marine Drugs, 2010 The 1,4-benzoquinone moiety is a common structural feature in a large number of compounds that have received considerable attention owing to their broad spectrum of biological activities.
Marina Gordaliza
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Regioselectivity of conjugate additions to monoalkyl-1,4-benzoquinones [PDF]
Journal of the Serbian Chemical Society, 2002 The regioselectivity of the reaction of conjugate addition of thiols, amines, methanol and hydrogen chloride with the monoalkyl-1,4-benzoquinones avarone and 2-tert-butyl-1,4-benzoquinone was investigated.
SNEZANA TRIFUNOVIC +5 more
doaj +3 more sources