Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice [PDF]
Molecules, 2021 Memory deterioration in Alzheimer’s disease (AD) is thought to be underpinned by aberrant amyloid β (Aβ) accumulation, which contributes to synaptic plasticity impairment. Avenanthramide-C (Avn-C), a polyphenol compound found predominantly in oats, has a
Ming Wang
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Avenanthramide C suppresses hypoxia-induced cyclooxygenase-2 expression through sirtuin1 activation in non-small-cell lung cancer cells [PDF]
Animal Cells and Systems, 2020 Avenanthramide C (AVC), found mainly in oats, mediates anti-inflammatory activities by reducing the anti-inflammatory cytokine levels. This study investigated the effects of AVC on hypoxia-induced cyclooxygenase-2 (COX-2) expression in A549 cells.
Wonchung Lim
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Efficiency of antioxidant Avenanthramide-C on high-dose methotrexate-induced ototoxicity in mice. [PDF]
PLoS ONE, 2022 Methotrexate (MTX) has been used in treating various types of cancers but can also cause damage to normal organs and cell types. Folinic acid (FA) is a well-known MTX antidote that protects against toxicity caused by the drug and has been used for ...
Alphonse Umugire +3 more
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Avenanthramide C as a novel candidate to alleviate osteoarthritic pathogenesis. [PDF]
BMB Rep, 2021 Osteoarthritis (OA) is a degenerative disorder that can result in the loss of articular cartilage. No effective treatment against OA is currently available. Thus, interest in natural health products to relieve OA symptoms is increasing.
Tran TT +6 more
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Avenanthramide C Prevents Neuronal Apoptosis via PI3K/Akt/GSK3β Signaling Pathway Following Middle Cerebral Artery Occlusion [PDF]
Brain Sciences, 2020 Avenanthramides are a group of phenolic alkaloids that have been shown to have anti-inflammatory, anti-oxidant, anti-atherogenic, and vasodilation effects.
Baoyuan Jin +4 more
doaj +5 more sources
Avenanthramide C Suppresses Matrix Metalloproteinase-9 Expression and Migration Through the MAPK/NF- κB Signaling Pathway in TNF-α-Activated HASMC Cells [PDF]
Frontiers in Pharmacology, 2021 In oat ingredients, flavonoids and phenolic acids are known to be the most important phenolic compounds. In phenolic compounds, wide-ranging biological responses, including antioxidative, anti-inflammatory, anti-allergic, and anti-cancer properties, were
Junyoung Park +10 more
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Avenanthramide C mitigates cisplatin-induced hippocampal neurotoxicity and cognitive impairment in rats via suppression of neuroinflammation and neuronal apoptosis [PDF]
Frontiers in PharmacologyIntroductionCisplatin (CP)-induced cognitive impairment, commonly referred to as chemobrain, affects a substantial proportion of patients with cancer and currently lacks an effective pharmacological treatment.
Maha Abdulrahman Aldubayan
doaj +3 more sources
Avenanthramide-C as Alzheimer’s Disease-Modifying Therapy: Early and Sustained Intervention Prevents Disease Progression in Mouse Models [PDF]
CellsMost approved drugs for Alzheimer’s disease (AD) are indicated for early to moderate stages and primarily target amyloid-beta or neurotransmitter systems.
Alen Benhur Pravin Nathan +7 more
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Protective effects of avenanthramide-C against cisplatin-induced cardiotoxicity in rats by attenuating oxidative stress, inflammatory cytokines, and modulating p62–Keap1–Nrf2 pathway [PDF]
Frontiers in PharmacologyIntroductionCisplatin (CIS) is widely recognized as a potent antineoplastic agent, especially effective for treating various solid tumors. Nevertheless, the pathological response it induces, alongside oxidative stress and inflammation from upstream ...
Maha Abdulrahman Aldubayan
doaj +3 more sources
Avenanthramide C and chondroitin sulphate promote chondrogenic differentiation of adipose-derived mesenchymal stem cells [PDF]
Scientific ReportsLoss of functional chondrocytes contributes to cartilage degeneration. Autologous transplantation of adipose-derived mesenchymal stem cells (ASCs) offers a promising approach for cartilage repair; however, current differentiation protocols remain ...
Priscila Sun +3 more
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