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Highly electrophilic, <i>gem-</i> and <i>spiro-</i>activated trichloromethylnitrocyclopropanes: synthesis and structure. [PDF]

open access: yesBeilstein J Org Chem
Pilipenko IA   +6 more
europepmc   +1 more source
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Avenanthramide C from Oats Protects Pyroptosis through Dependent ROS-Induced Mitochondrial Damage by PI3K Ubiquitination and Phosphorylation in Pediatric Pneumonia

Journal of Agricultural and Food Chemistry, 2022
Oat containing rich β-glucan, polyphenols, flavonoids, saponins, alkaloids, and other substances shows good biological activities. Therefore, the present study aimed to uncover the possible mechanism and therapeutic effect of Avenanthramide C in lessening inflammatory responses in pediatric pneumonia.
Zhichen Pu   +4 more
openaire   +4 more sources

Yeast cell wall capsules for delivery of oat biomarker avenanthramide-C

Food Chemistry
Avenanthramide-C (AVN-C) is the biomarker for oat with a variety of physiological functions, whereas its application is constrained by low stability and bioavailability. Avenanthramide-C is the biomarker for oat with a variety of physiological functions, whereas its application is constrained by low stability and bioavailability.
Linyang, He   +6 more
openaire   +4 more sources

Avenanthramide C induces cellular senescence in colorectal cancer cells via suppressing β-catenin-mediated the transcription of miR-183/96/182 cluster

Biochemical Pharmacology, 2022
Cellular senescence is representing a potential anticancer therapeutic arsenal. Avenanthramide C (AVN C), as a signature compound of oats, exhibits antioxidant, anti-inflammatory, anti-atherosclerotic, and anti-tumor activities. However, the relationship between AVN C and cellular senescence in tumors remains largely unclear.
Rong, Fu   +5 more
openaire   +4 more sources

Avenanthramide-C prevents amyloid formation of bovine serum albumin

Biophysical Chemistry, 2020
The misfolding of protein and its assembly into amyloid fibrils with a characteristic β-sheet-rich secondary structure, cause a lot of illnesses. Polyphenols have been extensively studied as a class of amyloid inhibitors, whose effect depends on the position and number of hydroxyl groups around the flavone backbone.
Maria Guadalupe, Quiroz Vazquez   +3 more
openaire   +2 more sources

Avenanthramide-C Activates Nrf2/ARE Pathway and Inhibiting Ferroptosis Pathway to Improve Cognitive Dysfunction in Aging Rats

Neurochemical Research, 2022
Postoperative neurocognitive impairment (POCD) is a common complication after surgery and anesthesia, especially in elderly patients. Avenanthramide-C (AVC) test is a vascular endothelial cell adhesion molecule inhibitor with strong anti-inflammatory and antioxidant effects.
Zijian, Ma   +4 more
openaire   +2 more sources

Identification of a novel senomorphic agent, avenanthramide C, via the suppression of the senescence-associated secretory phenotype

Mechanisms of Ageing and Development, 2020
Senescent cells are deeply involved in the induction of tissue damage and aging-related diseases. The identification of factors that eliminate senescent cells or inhibit the senescence-associated secretory phenotype (SASP) in these cells is necessary. Here, we report an avenanthramice C (Avn C) extracted from oat as a new SASP modulator. Treatment with
Jae Sung, Lim   +7 more
openaire   +2 more sources

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