From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Does Social Learning Promote Farmers’ Cooperative Pest Control?—Evidence from Northwestern China
AgriculturePest management is pivotal for ensuring secure grain production and constitutes a fundamental strategy in combating pests that detrimentally affect grain supplies.
Xinjie Li, Liu Yang, Qian Lu
doaj +1 more source
BOUNDS ON THE CONDITIONAL AND AVERAGE TREATMENT EFFECT WITH UNOBSERVED CONFOUNDING FACTORS. [PDF]
Ann Stat, 2022 Yadlowsky S +4 more
europepmc +1 more source
Estimating Heterogeneity in the Benefits of Medical Treatment Intensity [PDF]
Federal and state laws passed in the late 1990 increased considerably postpartum stays for newborns. Using all births in California over the 1995-2001 period, 2SLS estimates suggest that for the average newborn impacted by the law, increased treatment ...
Craig L. Garthwaite, William N. Evans
core
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Estimation of the average treatment effect with variable selection and measurement error simultaneously addressed for potential confounders. [PDF]
Stat Methods Med Res, 2023 Yi GY, Chen LP.
europepmc +1 more source
Threshold Crossing Models and Bounds on Treatment Effects: A Nonparametric Analysis [PDF]
This paper considers the evaluation of the average treatment effect of a binary endogenous regressor on a binary outcome when one imposes a threshold crossing model on both the endogenous regressor and the outcome variable but without imposing parametric
Azeem Shaikh, Edward Vytlacil
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Journal of Agriculture and Environment for International DevelopmentContract farming was introduced in Nigeria to address the challenges faced by smallholder farming households in realising farming objectives. Therefore, this study examined the effectiveness of the Anchor-borrower Outgrowers’ Programme in fulfilling one
Olabisi Damilola Omodara +2 more
doaj +1 more source