Results 131 to 140 of about 2,078,941 (236)

Self-Attentive Quantile GAN With Causally Grounded Machine Learning for Vocal Biomarker Discovery in Parkinson’s Disease Detection

IEEE Access
Parkinson’s disease (PD) detection through voice analysis faces two fundamental challenges: traditional machine learning methods lack clinical interpretability due to their correlational nature, while existing causal inference approaches struggle ...
Meghana Sunil, V. Shravya, S. Nachiyappan   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Estrogen Treatment Lowers the Risk of Complications in Menopausal Women with Mild Burn Injury

Medicina
Background and Objectives: Postmenopausal women are often treated with exogenous female hormones to alleviate physical symptoms and support mental health. We posit that women treated with estrogen fare better following burn injury. Materials and Methods:
Juquan Song, George Golovko, Kostiantyn Botnar, Amina El Ayadi, Kathleen L. Vincent, Steven E. Wolf   +5 more
doaj   +1 more source

A note on estimation of the average treatment effect and average partial effect in nonlinear models [PDF]

In the literature on program impact evaluation, the popular impact parameters can the average treatment effect, the average treatment effect on the treated, the average partial effect, and the average partial effect on the treated.
Cuong Nguyen Viet
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Manifold Causal Conditional Deep Networks for Heterogeneous Treatment Effect Estimation and Policy Evaluation

Mathematics
We present a comprehensive framework for estimating heterogeneous treatment effects and evaluating decision-making policies in high-dimensional settings.
Jong-Min Kim
doaj   +1 more source

Bayesian and frequentist bootstrapped estimates of the average treatment effect.

, 2019
Bayesian and frequentist bootstrapped estimates of the average treatment effect.
Emma J. McCoy (7387676), Haojie Li (273528), Cian Naik (7387673), Daniel J. Graham (677660)   +3 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IDENTIFICATION AND INFERENCE FOR MARGINAL AVERAGE TREATMENT EFFECT ON THE TREATED WITH AN INSTRUMENTAL VARIABLE. [PDF]

Stat Sin, 2020
Liu L, Miao W, Sun B, Robins J, Tchetgen ET.   +4 more
europepmc   +1 more source